Genotype – Phenotype Correlations of β-Thalassemia Mutations in Azerbaijani population
β-Thalassemia is the most common inherited disorder in Azerbaijan. The aim of our study was to reveal genotype-to-phenotype correlations of the most common β-thalassemia mutations in an Azerbaijani population. Patients with codon 8 (-AA), IVS-I-6 (T>C), and IVS-II-1 (G>A) mutations, which are...
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| Published in | Turkish journal of haematology Vol. 34; no. 3; pp. 258 - 263 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Turkey
Türk Hematoloji Derneği
02.08.2017
Galenos Publishing House Galenos Publishing |
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| Online Access | Get full text |
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| Abstract | β-Thalassemia is the most common inherited disorder in Azerbaijan. The aim of our study was to reveal genotype-to-phenotype correlations of the most common β-thalassemia mutations in an Azerbaijani population. Patients with codon 8 (-AA), IVS-I-6 (T>C), and IVS-II-1 (G>A) mutations, which are reportedly the most common β-globin gene mutations among the local population, were tested for hematologic parameters. Fifty-five previously tested patients with known genotypes were included in the study. Hematologic indices and hemoglobin fractions were tested in order to reveal the phenotypic manifestation of the mutations. The results obtained indicate that clinical presentation varies between different β-globin gene mutations: individuals with IVS-I-6 (T>C) mutations showed milder presentation than those with codon 8 (-AA) and IVS-II-1 (G>A), which is associated with the molecular basis of the mutations. These data can be of assistance to predict clinical presentation and select the best possible therapeutic approach via early genotype identification. |
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| AbstractList | β-Thalassemia is the most common inherited disorder in Azerbaijan. The aim of our study was to reveal genotype-to-phenotype correlations of the most common β-thalassemia mutations in an Azerbaijani population. Patients with codon 8 (-AA), IVS-I-6 (T>C), and IVS-II-1 (G>A) mutations, which are reportedly the most common β-globin gene mutations among the local population, were tested for hematologic parameters. Fifty-five previously tested patients with known genotypes were included in the study. Hematologic indices and hemoglobin fractions were tested in order to reveal the phenotypic manifestation of the mutations. The results obtained indicate that clinical presentation varies between different β-globin gene mutations: individuals with IVS-I-6 (T>C) mutations showed milder presentation than those with codon 8 (-AA) and IVS-II-1 (G>A), which is associated with the molecular basis of the mutations. These data can be of assistance to predict clinical presentation and select the best possible therapeutic approach via early genotype identification. β-Thalassemia is the most common inherited disorder in Azerbaijan. The aim of our study was to reveal genotype-to-phenotype correlations of the most common β-thalassemia mutations in an Azerbaijani population. Patients with codon 8 (-AA), IVS-I-6 (T>C), and IVS-II-1 (G>A) mutations, which are reportedly the most common β-globin gene mutations among the local population, were tested for hematologic parameters. Fifty-five previously tested patients with known genotypes were included in the study. Hematologic indices and hemoglobin fractions were tested in order to reveal the phenotypic manifestation of the mutations. The results obtained indicate that clinical presentation varies between different β-globin gene mutations: individuals with IVS-I-6 (T>C) mutations showed milder presentation than those with codon 8 (-AA) and IVS-II-1 (G>A), which is associated with the molecular basis of the mutations. These data can be of assistance to predict clinical presentation and select the best possible therapeutic approach via early genotype identification. β-Thalassemia is the most common inherited disorder in Azerbaijan. The aim of our study was to reveal genotype-to-phenotype correlations of the most common β-thalassemia mutations in an Azerbaijani population. Patients with codon 8 (-AA), IVS-I-6 (T>C), and IVS-II-1 (G>A) mutations, which are reportedly the most common β-globin gene mutations among the local population, were tested for hematologic parameters. Fifty-five previously tested patients with known genotypes were included in the study. Hematologic indices and hemoglobin fractions were tested in order to reveal the phenotypic manifestation of the mutations. The results obtained indicate that clinical presentation varies between different β-globin gene mutations: individuals with IVS-I-6 (T>C) mutations showed milder presentation than those with codon 8 (-AA) and IVS-II-1 (G>A), which is associated with the molecular basis of the mutations. These data can be of assistance to predict clinical presentation and select the best possible therapeutic approach via early genotype identification.β-Thalassemia is the most common inherited disorder in Azerbaijan. The aim of our study was to reveal genotype-to-phenotype correlations of the most common β-thalassemia mutations in an Azerbaijani population. Patients with codon 8 (-AA), IVS-I-6 (T>C), and IVS-II-1 (G>A) mutations, which are reportedly the most common β-globin gene mutations among the local population, were tested for hematologic parameters. Fifty-five previously tested patients with known genotypes were included in the study. Hematologic indices and hemoglobin fractions were tested in order to reveal the phenotypic manifestation of the mutations. The results obtained indicate that clinical presentation varies between different β-globin gene mutations: individuals with IVS-I-6 (T>C) mutations showed milder presentation than those with codon 8 (-AA) and IVS-II-1 (G>A), which is associated with the molecular basis of the mutations. These data can be of assistance to predict clinical presentation and select the best possible therapeutic approach via early genotype identification. [...]determination of factors causing such a diverse clinical presentation has clinical significance, and the major reason for such diversity is the variety of mutations [11,12,13,14,15,16]. Evaluations of red blood cell (RBC) count, hemoglobin concentration, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) were performed with a Sysmex XT2000i hematology analyzer (Sysmex, Kobe, Japan). According to our data, hematologic parameters and consequently the clinical presentation are closely related to the type of the mutation, especially in homozygous patients. Authorship Contributions Surgical and Medical Practices: T.M., E.A.; Concept: C.A.; Design: C.A., T.M., E.A.; Data Collection or Processing: E.A., S.G., Y.G.; Analysis or Interpretation: C.A., T.M., E.A., G.A.; Literature Search: C.A., G.A.; Writing: C.A., T.M., G.A. Conflict of Interest: The authors of this paper have no conflicts of interest, including specific financial interests, relationships, and/or affiliations relevant to the subject matter or materials included. |
| Abstract_FL | β-Talasemi Azerbaycan’da görülen en sık kalıtsal hastalıktır.
Çalışmamızın amacı Azerbaycan popülasyonunda en sık görülen
β-talasemi mutasyonlarının genotip-fenotip korelasyonlarının
ortaya çıkarılmasıydı. Yerel popülasyonda en sık görülen β-globin
gen mutasyonları olan kodon 8 (-AA), IVS-I-6 (T>C) ve IVS-II-1
(G>A) mutasyonlarını taşıyan hastalar hematolojik parametreler
açısından değerlendirildi. Daha önceden test edilmiş ve genotipik
özellikleri bilinen 55 hasta çalışmaya dahil edildi. Mutasyonların
fenotipik manifestasyonlarının gösterilmesi için hematolojik indeksler
ve hemoglobin fraksiyonlarına bakıldı. Sonuçlar farklı β-globin gen
mutasyonları arasında klinik başvuru açısından farklılıklar olduğunu
göstermekteydi: IVS-I-6 (T>C) mutasyonu olan bireylerde hastalık
kodon 8 (-AA) ve IVS-II-1 (G>A) mutasyonu olanlara göre daha
hafif seyretmekteydi. Erken genotipik tanımlama klinik başvuru
özelliklerinin tahmin edilmesine ve hastalara en iyi terapötik
yaklaşımların uygulanmasına yardımcı olabilir. |
| Author | Aliyeva, Gunay Gafarova, Surmaya Guliyeva, Yegana Mammadova, Tahira Abdulalimov, Eldar Asadov, Chingiz |
| AuthorAffiliation | Eritrosit Sisteminin Herediter Patolojisi Anabilim Dalı |
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| Copyright | Copyright Galenos Yayinevi 2017 Copyright 2017 by Turkish Society of Hematology Turkish Journal of Hematology published by Galenos Publishing House. 2017 |
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| Keywords | Phenotype Codon Orak/b talasemi Fenotip Talasemi Thalassemia Genotype Genotip Kodon Sickle/β-thalassemia |
| Language | English |
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| References | 1483699 - Hum Genet. 1992 Dec;90(4):417-9 26865931 - Int J Hematol Oncol Stem Cell Res. 2015 Oct 1;9(4):198-202 1728311 - Blood. 1992 Jan 1;79(1):238-43 18410566 - Br J Haematol. 2008 May;141(3):276-86 7522523 - Br J Haematol. 1994 Apr;86(4):824-30 22058279 - Haematologica. 2011 Nov;96(11):1573-5 22826799 - Hematol Rep. 2012 May 10;4(2):e9 6458808 - Probl Gematol Pereliv Krovi. 1981 Sep;26(9):51-3 9234571 - Haematologica. 1997 May-Jun;82(3):269-80 11857738 - Hum Mutat. 2002 Mar;19(3):225-33 6458805 - Probl Gematol Pereliv Krovi. 1981 Sep;26(9):12-6 8980256 - Am J Hematol. 1997 Jan;54(1):16-22 21039591 - Ann N Y Acad Sci. 2010 Dec;1214:47-56 1834514 - Gematol Transfuziol. 1991 Jul;36(7):16-8 20492708 - Orphanet J Rare Dis. 2010 May 21;5:11 7504400 - Am J Hematol. 1994 Jan;45(1):51-7 18568278 - Bull World Health Organ. 2008 Jun;86(6):480-7 8014969 - J Med Genet. 1994 Mar;31(3):209-12 20233970 - Blood. 2010 Jun 3;115(22):4331-6 23510507 - Hemoglobin. 2013;37(3):291-6 11283697 - Nat Rev Genet. 2001 Apr;2(4):245-55 |
| References_xml | – reference: 18410566 - Br J Haematol. 2008 May;141(3):276-86 – reference: 20492708 - Orphanet J Rare Dis. 2010 May 21;5:11 – reference: 6458805 - Probl Gematol Pereliv Krovi. 1981 Sep;26(9):12-6 – reference: 8014969 - J Med Genet. 1994 Mar;31(3):209-12 – reference: 6458808 - Probl Gematol Pereliv Krovi. 1981 Sep;26(9):51-3 – reference: 11283697 - Nat Rev Genet. 2001 Apr;2(4):245-55 – reference: 1483699 - Hum Genet. 1992 Dec;90(4):417-9 – reference: 7522523 - Br J Haematol. 1994 Apr;86(4):824-30 – reference: 26865931 - Int J Hematol Oncol Stem Cell Res. 2015 Oct 1;9(4):198-202 – reference: 22826799 - Hematol Rep. 2012 May 10;4(2):e9 – reference: 18568278 - Bull World Health Organ. 2008 Jun;86(6):480-7 – reference: 7504400 - Am J Hematol. 1994 Jan;45(1):51-7 – reference: 11857738 - Hum Mutat. 2002 Mar;19(3):225-33 – reference: 23510507 - Hemoglobin. 2013;37(3):291-6 – reference: 1728311 - Blood. 1992 Jan 1;79(1):238-43 – reference: 22058279 - Haematologica. 2011 Nov;96(11):1573-5 – reference: 21039591 - Ann N Y Acad Sci. 2010 Dec;1214:47-56 – reference: 8980256 - Am J Hematol. 1997 Jan;54(1):16-22 – reference: 9234571 - Haematologica. 1997 May-Jun;82(3):269-80 – reference: 20233970 - Blood. 2010 Jun 3;115(22):4331-6 – reference: 1834514 - Gematol Transfuziol. 1991 Jul;36(7):16-8 |
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| Snippet | β-Thalassemia is the most common inherited disorder in Azerbaijan. The aim of our study was to reveal genotype-to-phenotype correlations of the most common... β-Thalassemia is the most common inherited disorder in Azerbaijan. The aim of our study was to reveal genotype-to-phenotype correlations of the most common... [...]determination of factors causing such a diverse clinical presentation has clinical significance, and the major reason for such diversity is the variety of... |
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| SubjectTerms | Adolescent Adult Azerbaijan beta-Globins - genetics beta-Thalassemia - genetics Blood Brief Report Child Child, Preschool Codon Female Genes Genotype Genotype & phenotype Hemoglobin Humans Male Middle Aged Mutation phenotype Population sickle/β thalassemia Tıp |
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| Title | Genotype – Phenotype Correlations of β-Thalassemia Mutations in Azerbaijani population |
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