Cerebrospinal fluid biomarkers of central catecholamine deficiency in Parkinson’s disease and other synucleinopathies

• Published in: Brain (London, England : 1878) Vol. 135; no. 6; pp. 1900 - 1913
• Main Authors: Goldstein, David S., Holmes, Courtney, Sharabi, Yehonatan
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.06.2012
• Subjects: 3,4-Dihydroxyphenylacetic Acid - cerebrospinal fluid; Aged; Biological and medical sciences; Biomarkers - blood; Biomarkers - cerebrospinal fluid; Catecholamines - blood; Catecholamines - cerebrospinal fluid; Catecholamines - deficiency; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dopamine Agents - therapeutic use; Female; Fluorodeoxyglucose F18; Follow-Up Studies; Humans; Levodopa - therapeutic use; Male; Medical sciences; Methoxyhydroxyphenylglycol - analogs & derivatives; Methoxyhydroxyphenylglycol - blood; Methoxyhydroxyphenylglycol - cerebrospinal fluid; Middle Aged; Multiple System Atrophy - blood; Multiple System Atrophy - cerebrospinal fluid; Multiple System Atrophy - diagnostic imaging; Multiple System Atrophy - drug therapy; Neurology; Original; Parkinsonian Disorders - cerebrospinal fluid; Parkinsonian Disorders - diagnostic imaging; Parkinsonian Disorders - drug therapy; Positron-Emission Tomography; Pure Autonomic Failure - blood; Pure Autonomic Failure - cerebrospinal fluid; Pure Autonomic Failure - diagnostic imaging; Pure Autonomic Failure - drug therapy; ROC Curve; Parkinson's; Nervous system diseases; Dopamine; DOPAC; Deficiency; Parkinson disease; Cerebrospinal fluid; Catecholamine; biomarker; Cerebral disorder; Central nervous system disease; Neurotransmitter; Degenerative disease; Norepinephrine; DHPG; Extrapyramidal syndrome

Central catecholamine deficiency characterizes α-synucleinopathies such as Parkinson's disease. We hypothesized that cerebrospinal fluid levels of neuronal metabolites of catecholamines provide neurochemical biomarkers of these disorders. To test this hypothesis we measured cerebrospinal fluid...