Oxidation of the FAD cofactor to the 8-formyl-derivative in human electron-transferring flavoprotein - Augustin, Peter; Toplak, Marina; Fuchs, Katharina; Gerstmann, Eva Christine; Prassl, Ruth; Winkler, Andreas; Macheroux, Peter (The Journal of biological chemistry, 2018)
Keywords: 8-formyl-FAD; Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Biocatalysis; Catalytic Domain; Conserved Sequence; dehydrogenase; electron transfer; Electron Transport; Electron-Transferring Flavoproteins - chemistry; Electron-Transferring Flavoproteins - genetics; Electron-Transferring Flavoproteins - metabolism; Enzymology; flavin adenine dinucleotide (FAD); flavin semiquinone; Flavin-Adenine Dinucleotide - analogs & derivatives; Flavin-Adenine Dinucleotide - chemistry; Flavin-Adenine Dinucleotide - metabolism; Humans; Hydrogen-Ion Concentration; mitochondria; Models, Molecular; Multiple Acyl Coenzyme A Dehydrogenase Deficiency - enzymology; Multiple Acyl Coenzyme A Dehydrogenase Deficiency - genetics; Mutagenesis, Site-Directed; Mutation; Oxidation-Reduction; Protein Engineering; Protein Multimerization; Recombinant Proteins - chemistry; Recombinant Proteins - metabolism; respiratory chain; flavin adenine dinucleotide (FAD); electron transfer; 8-formyl-FAD; mitochondria; dehydrogenase; flavin semiquinone; respiratory chain