Computational Fluid Dynamics (CFD) Simulations of Spray Drying: Linking Drying Parameters with Experimental Aerosolization Performance

• Published in: Pharmaceutical research Vol. 37; no. 6; p. 101
• Main Authors: Longest, P. Worth, Farkas, Dale, Hassan, Amr, Hindle, Michael
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2020; Springer; Springer Nature B.V
• Subjects: Administration, Inhalation; Aerosols; Analysis; Biochemistry; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Chemistry, Pharmaceutical; Computer applications; Computer Simulation; Drug Compounding - methods; Dry Powder Inhalers; Drying; Excipients - chemistry; Fluid dynamics; Hydrodynamics; Inhalers; L-leucine; Leucine; Mass transfer; Medical Law; Models, Chemical; Particle Size; Pharmacology/Toxicology; Pharmacy; Research Paper; Simulation methods; Spray Drying; Dry powder inhaler; drying parameters; excipient enhanced growth aerosol formulations; particle engineering; pharmaceutical engineering; respiratory drug delivery

Purpose The purpose of this study was to develop a new computational fluid dynamics (CFD)-based model of the complex transport and droplet drying kinetics within a laboratory-scale spray dryer, and relate CFD-predicted drying parameters to powder aerosolization metrics from a reference dry powder in...