Comparative analysis of SARS-CoV-2 neutralization titers reveals consistency between human and animal model serum and across assays

• Published in: Science translational medicine Vol. 16; no. 747; p. eadl1722
• Main Authors: Mühlemann, Barbara, Wilks, Samuel H, Baracco, Lauren, Bekliz, Meriem, Carreño, Juan Manuel, Corman, Victor M, Davis-Gardner, Meredith E, Dejnirattisai, Wanwisa, Diamond, Michael S, Douek, Daniel C, Drosten, Christian, Eckerle, Isabella, Edara, Venkata-Viswanadh, Ellis, Madison, Fouchier, Ron A M, Frieman, Matthew, Godbole, Sucheta, Haagmans, Bart, Halfmann, Peter J, Henry, Amy R, Jones, Terry C, Katzelnick, Leah C, Kawaoka, Yoshihiro, Kimpel, Janine, Krammer, Florian, Lai, Lilin, Liu, Chang, Lusvarghi, Sabrina, Meyer, Benjamin, Mongkolsapaya, Juthathip, Montefiori, David C, Mykytyn, Anna, Netzl, Antonia, Pollett, Simon, Rössler, Annika, Screaton, Gavin R, Shen, Xiaoying, Sigal, Alex, Simon, Viviana, Subramanian, Rahul, Supasa, Piyada, Suthar, Mehul S, Türeli, Sina, Wang, Wei, Weiss, Carol D, Smith, Derek J
• Format: Journal Article
• Language: English
• Published: United States 15.05.2024
• Subjects: Animals; Antibodies, Neutralizing - blood; Antibodies, Neutralizing - immunology; Antibodies, Viral - blood; Antibodies, Viral - immunology; COVID-19 - blood; COVID-19 - immunology; COVID-19 - virology; Cricetinae; Disease Models, Animal; Humans; Mice; Neutralization Tests; SARS-CoV-2 - immunology

The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires ongoing monitoring to judge the ability of newly arising variants to escape the immune response. A surveillance system necessitates an understanding of differences in neutralization titers measured in different as...