Identification of key genes involved in the development and progression of early-onset colorectal cancer by co-expression network analysis

• Published in: Oncology letters Vol. 19; no. 1; pp. 177 - 186
• Main Authors: Mo, Xiaoqiong, Su, Zexin, Yang, Bingsheng, Zeng, Zhirui, Lei, Shan, Qiao, Hui
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.01.2020; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Age; Biochemistry; Bioinformatics; Biological markers; Biomarkers; Cancer genetics; Cancer metastasis; Cancer research; Collagen; Colorectal cancer; Cysteine; Cystine; Datasets; Development and progression; Elderly patients; Etiology (Medicine); Gene expression; Genes; Genetic aspects; Genomes; Genomics; Identification; Medical prognosis; Medical screening; Metastasis; Oncology; Principal components analysis; Protein binding; Protein-protein interactions; Proteins; RNA; Shock; Software; Survival analysis; Tumors; Ubiquitin; hub gene; tumor-node-metastasis stage; weighted gene co-expression network; early-onset colorectal cancer

A number of studies have revealed that there is an increasing incidence of early-onset colorectal cancer (CRC) in young adults (before the age of 50 years) and a progressive decline in CRC among older patients, after the age of 50 years (late-onset CRC). However, the etiology of early-onset CRC is n...