The bone-preserving effects of exendin-4 in ovariectomized rats

• Published in: Endocrine Vol. 51; no. 2; pp. 323 - 332
• Main Authors: Sun, Han-xiao, Lu, Nan, Liu, Dong-mei, Zhao, Lin, Sun, Li-hao, Zhao, Hong-yan, Liu, Jian-min, Tao, Bei
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2016
• Subjects: Adipogenesis - drug effects; Alkaline Phosphatase - metabolism; Animals; Bone Density - drug effects; Collagen Type I - metabolism; Core Binding Factor Alpha 1 Subunit - metabolism; Diabetes; Endocrinology; Female; Femur - drug effects; Femur - metabolism; Humanities and Social Sciences; Internal Medicine; Lumbar Vertebrae - drug effects; Lumbar Vertebrae - metabolism; Medicine; Medicine & Public Health; Mesenchymal Stromal Cells - drug effects; Mesenchymal Stromal Cells - metabolism; multidisciplinary; Original Article; Osteogenesis - drug effects; Ovariectomy; Peptides - pharmacology; PPAR gamma - genetics; Rats; Rats, Wistar; Science; Venoms - pharmacology; Bone mineral density; Bone micro-architecture; Ovariectomy; Rat; Exendin-4

Exendin-4 was found to be beneficial to the skeleton in diabetic rodents. In this study, we assessed the changes of bone mineral densities (BMDs) and quality in non-diabetic ovariectomized (OVX) rats after treatment with exendin-4. The regulatory role of exendin-4 on osteoblastogenesis and adipogene...