Sex/gender effects of glial reactivity on preclinical Alzheimer’s disease pathology

• Published in: Molecular psychiatry Vol. 30; no. 4; pp. 1430 - 1439
• Main Authors: Vila-Castelar, Clara, Akinci, Muge, Palpatzis, Eleni, Aguilar-Dominguez, Pablo, Operto, Gregory, Kollmorgen, Gwendlyn, Quijano-Rubio, Clara, Blennow, Kaj, Zetterberg, Henrik, Falcon, Carles, Fauria, Karine, Gispert, Juan Domingo, Grau-Rivera, Oriol, Suárez-Calvet, Marc, Arenaza-Urquijo, Eider M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2025; Nature Publishing Group
• Subjects: 101/1; 59/57; 692/53/2421; 692/699; 82/47; 82/51; Aged; Aged, 80 and over; Alzheimer Disease - cerebrospinal fluid; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; Amyloid beta-Peptides - cerebrospinal fluid; Amyloid beta-Peptides - metabolism; Behavioral Sciences; Biological Psychology; Biomarkers - cerebrospinal fluid; Cerebrospinal fluid; Chitinase-3-Like Protein 1 - cerebrospinal fluid; Clinical trials; Cohort Studies; Female; Gender; Gender differences; Glial fibrillary acidic protein; Glial Fibrillary Acidic Protein - cerebrospinal fluid; Hippocampus; Hippocampus - metabolism; Hippocampus - pathology; Humans; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Medicine; Medicine & Public Health; Membrane Glycoproteins - cerebrospinal fluid; Middle Aged; Neurodegenerative diseases; Neuroglia - metabolism; Neuronal-glial interactions; Neurosciences; Pathology; Peptide Fragments - cerebrospinal fluid; Pharmacotherapy; Positron emission tomography; Positron-Emission Tomography - methods; Psychiatry; Psykiatri; Receptors, Immunologic; Regression analysis; Sex Characteristics; Sex differences; Sex Factors; Tau protein; tau Proteins - cerebrospinal fluid; tau Proteins - metabolism

Glial reactivity may contribute to sex/gender differences in Alzheimer’s disease (AD) pathophysiology. Here, we investigated the differential effect of cerebrospinal fluid (CSF) glial markers on AD pathology and neurodegeneration by sex/gender among cognitively unimpaired older adults at increased r...