In vivo characterization of the early states of the amyloid-beta network
Alzheimer's disease is a neurodegenerative disease that is associated with the abnormal accumulation of amyloid-β. Much is known about regional brain atrophy in Alzheimer's disease, yet our knowledge about the network nature of Alzheimer's disease-associated amyloid-β accumulation is...
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Published in | Brain (London, England : 1878) Vol. 136; no. Pt 7; pp. 2239 - 2252 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Oxford University Press
01.07.2013
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Abstract | Alzheimer's disease is a neurodegenerative disease that is associated with the abnormal accumulation of amyloid-β. Much is known about regional brain atrophy in Alzheimer's disease, yet our knowledge about the network nature of Alzheimer's disease-associated amyloid-β accumulation is limited. We use stepwise connectivity analysis of Pittsburgh Compound B positron emission tomography images to reveal the network properties of amyloid-β deposits in normal elderly subjects and clinical patients with Alzheimer's disease. We found that amyloid-β accumulation in the medial temporal lobe is associated with accumulation in cortical regions such as orbitofrontal, lateral temporal and precuneus/posterior cingulate cortices in Alzheimer's disease. In normal subjects, there was a predominant association between amyloid-β deposits in the hippocampus and the midline prefrontal/orbitofrontal regions, even in those with very low amyloid-β burden. Moreover, the orbitofrontal cortex, amygdala nucleus and hippocampus exhibit hub properties in the amyloid-β network that may be critical to understanding the putative spreading mechanisms of Alzheimer's disease pathology in early stages. |
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AbstractList | Alzheimer's disease is a neurodegenerative disease that is associated with the abnormal accumulation of amyloid- beta . Much is known about regional brain atrophy in Alzheimer's disease, yet our knowledge about the network nature of Alzheimer's disease-associated amyloid- beta accumulation is limited. We use stepwise connectivity analysis of Pittsburgh Compound B positron emission tomography images to reveal the network properties of amyloid- beta deposits in normal elderly subjects and clinical patients with Alzheimer's disease. We found that amyloid- beta accumulation in the medial temporal lobe is associated with accumulation in cortical regions such as orbitofrontal, lateral temporal and precuneus/posterior cingulate cortices in Alzheimer's disease. In normal subjects, there was a predominant association between amyloid- beta deposits in the hippocampus and the midline prefrontal/orbitofrontal regions, even in those with very low amyloid- beta burden. Moreover, the orbitofrontal cortex, amygdala nucleus and hippocampus exhibit hub properties in the amyloid- beta network that may be critical to understanding the putative spreading mechanisms of Alzheimer's disease pathology in early stages. Alzheimer's disease is a neurodegenerative disease that is associated with the abnormal accumulation of amyloid-β. Much is known about regional brain atrophy in Alzheimer's disease, yet our knowledge about the network nature of Alzheimer's disease-associated amyloid-β accumulation is limited. We use stepwise connectivity analysis of Pittsburgh Compound B positron emission tomography images to reveal the network properties of amyloid-β deposits in normal elderly subjects and clinical patients with Alzheimer's disease. We found that amyloid-β accumulation in the medial temporal lobe is associated with accumulation in cortical regions such as orbitofrontal, lateral temporal and precuneus/posterior cingulate cortices in Alzheimer's disease. In normal subjects, there was a predominant association between amyloid-β deposits in the hippocampus and the midline prefrontal/orbitofrontal regions, even in those with very low amyloid-β burden. Moreover, the orbitofrontal cortex, amygdala nucleus and hippocampus exhibit hub properties in the amyloid-β network that may be critical to understanding the putative spreading mechanisms of Alzheimer's disease pathology in early stages. |
Author | SEPULCRE, Jorge SABUNCU, Mert R JOHNSON, Keith A SPERLING, Reisa BECKER, Alex |
AuthorAffiliation | 1 Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA 5 Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA 2 Athinioula A. Martinos Centre for Biomedical Imaging, Charlestown, MA, USA 4 Centre for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA 3 Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA |
AuthorAffiliation_xml | – name: 3 Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA – name: 4 Centre for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA – name: 5 Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA – name: 2 Athinioula A. Martinos Centre for Biomedical Imaging, Charlestown, MA, USA – name: 1 Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA |
Author_xml | – sequence: 1 givenname: Jorge surname: SEPULCRE fullname: SEPULCRE, Jorge organization: Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States – sequence: 2 givenname: Mert R surname: SABUNCU fullname: SABUNCU, Mert R organization: Athinioula A. Martinos Centre for Biomedical imaging, Charlestown, MA, United States – sequence: 3 givenname: Alex surname: BECKER fullname: BECKER, Alex organization: Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States – sequence: 4 givenname: Reisa surname: SPERLING fullname: SPERLING, Reisa organization: Athinioula A. Martinos Centre for Biomedical imaging, Charlestown, MA, United States – sequence: 5 givenname: Keith A surname: JOHNSON fullname: JOHNSON, Keith A organization: Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States |
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Keywords | Nervous system diseases Alzheimer disease early stages Central nervous system disease Early stage Degenerative disease Amyloid Graph theory Alzheimer's disease Cerebral disorder network amyloid Alzheimer’s disease graph theory |
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Snippet | Alzheimer's disease is a neurodegenerative disease that is associated with the abnormal accumulation of amyloid-β. Much is known about regional brain atrophy... Alzheimer's disease is a neurodegenerative disease that is associated with the abnormal accumulation of amyloid- beta . Much is known about regional brain... Alzheimer’s disease is a neurodegenerative disease that is associated with the abnormal accumulation of amyloid-β. Much is known about regional brain atrophy... |
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Title | In vivo characterization of the early states of the amyloid-beta network |
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