Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes

• Published in: American journal of physiology: endocrinology and metabolism Vol. 292; no. 3; pp. E740 - E747
• Main Authors: Creely, S. J, McTernan, P. G, Kusminski, C. M, Fisher, ff. M, Da Silva, N. F, Khanolkar, M, Evans, M, Harte, A. L, Kumar, S
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.03.2007
• Subjects: Adipocytes, White - drug effects; Adipocytes, White - immunology; Adipocytes, White - metabolism; Adipose tissue; Adult; Aged; Cells; Cells, Cultured; Cytokines; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - immunology; Diabetes Mellitus, Type 2 - pathology; Female; Health risks; Humans; Immune response; Immune system; Immunity, Innate - drug effects; Inflammatory diseases; Insulin; Lipopolysaccharides - pharmacology; Male; Middle Aged; Myeloid Differentiation Factor 88 - metabolism; NF-kappa B - antagonists & inhibitors; Obesity - blood; Obesity - immunology; Obesity - pathology; Subcutaneous Fat, Abdominal - drug effects; Subcutaneous Fat, Abdominal - immunology; Subcutaneous Fat, Abdominal - metabolism; Tissues; TNF Receptor-Associated Factor 6 - metabolism; Toll-Like Receptors - metabolism

1 Diabetes and Metabolism Research Laboratories, Clinical Sciences Research Institute, Warwick Medical School; 2 University Hospital of Coventry and Warwickshire, Coventry, England; and 3 Heart Research Institute, Cardiff University, Wales, United Kingdom Submitted 23 June 2006 ; accepted in final f...