Flavin Oxidase-Induced ROS Generation Modulates PKC Biphasic Effect of Resveratrol on Endothelial Cell Survival

• Published in: Biomolecules (Basel, Switzerland) Vol. 9; no. 6; p. 209
• Main Authors: Posadino, Anna Maria, Giordo, Roberta, Cossu, Annalisa, Nasrallah, Gheyath K, Shaito, Abdullah, Abou-Saleh, Haissam, Eid, Ali H, Pintus, Gianfranco
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 30.05.2019; MDPI AG
• Subjects: anti- and pro-oxidant effect; Cell Cycle - drug effects; cell damage; Cell Survival - drug effects; Dinitrocresols - metabolism; dose-dependence; endothelial cells; flavin oxidase; Human Umbilical Vein Endothelial Cells - cytology; Human Umbilical Vein Endothelial Cells - drug effects; Human Umbilical Vein Endothelial Cells - metabolism; Humans; Intracellular Space - drug effects; Intracellular Space - metabolism; Oxidation-Reduction - drug effects; Oxidoreductases - metabolism; PKC; Protein Kinase C - metabolism; Reactive Oxygen Species - metabolism; resveratrol; Resveratrol - pharmacology; ROS; endothelial cells; cell damage; dose-dependence; flavin oxidase; ROS; PKC; anti- and pro-oxidant effect; resveratrol

Dietary intake of natural antioxidants is thought to impart protection against oxidative-associated cardiovascular diseases. Despite many in vivo studies and clinical trials, this issue has not been conclusively resolved. Resveratrol (RES) is one of the most extensively studied dietary polyphenolic...