Cardiac Fibroblast p38 MAPK: A Critical Regulator of Myocardial Remodeling

• Published in: Journal of cardiovascular development and disease Vol. 6; no. 3; p. 27
• Main Authors: Turner, Neil A., Blythe, Nicola M.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 07.08.2019; MDPI AG
• Subjects: cardiac remodeling; extracellular matrix; fibroblast; fibrosis; heart; hypertrophy; inflammation; myofibroblast; p38 MAP kinase; Review; signal transduction; stress-activated protein kinase; transcription factor; p38 MAP kinase; transcription factor; fibroblast; stress-activated protein kinase; hypertrophy; inflammation; myofibroblast; signal transduction; cardiac remodeling; fibrosis; extracellular matrix; heart

The cardiac fibroblast is a remarkably versatile cell type that coordinates inflammatory, fibrotic and hypertrophic responses in the heart through a complex array of intracellular and intercellular signaling mechanisms. One important signaling node that has been identified involves p38 MAPK; a famil...