Effects of TGF‑β1 on the migration and morphology of RAW264.7 cells in vitro

• Published in: Molecular medicine reports Vol. 20; no. 5; pp. 4331 - 4339
• Main Authors: Ueta, Miho, Takaoka, Kazuki, Yamamura, Michiyo, Maeda, Hanako, Tamaoka, Joji, Nakano, Yoshioro, Noguchi, Kazuma, Kishimoto, Hiromitsu
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications UK Ltd 01.11.2019
• Subjects: Acid phosphatase (tartrate-resistant); Actin Cytoskeleton - metabolism; Animals; Biomarkers; Cell Adhesion; Cell adhesion & migration; Cell culture; Cell differentiation; Cell Differentiation - drug effects; Cell morphology; Cell Movement - drug effects; Cell proliferation; Chemotaxis; Chemotaxis - drug effects; Cytology; Gene Expression Regulation - drug effects; Growth factors; Hemopoiesis; Leukocyte migration; Ligands; Macrophages; Macrophages - drug effects; Macrophages - metabolism; Mice; Monocytes; Morphology; NF-κB protein; Osteoclastogenesis; Osteoclasts; Osteoclasts - cytology; Osteoclasts - drug effects; Osteoclasts - metabolism; RANK Ligand - metabolism; RANK Ligand - pharmacology; RAW 264.7 Cells; Recombinant Proteins - pharmacology; rho GTP-Binding Proteins - genetics; rho GTP-Binding Proteins - metabolism; RhoA protein; Signal transduction; TRANCE protein; Transforming Growth Factor beta1 - metabolism; Transforming Growth Factor beta1 - pharmacology; Transforming growth factor-b1

Osteoclasts (OCs) differentiate from monocyte/macrophage‑lineage hematopoietic precursor cells, which are known as OC precursors (OCPs). Several studies have investigated cell chemotaxis in the bone microenvironment; however, OCP migration ability in the bone microenvironment during OC differentiati...