Pathologic angiogenesis in the bone marrow of humanized sickle cell mice is reversed by blood transfusion

• Published in: Blood Vol. 135; no. 23; pp. 2071 - 2084
• Main Authors: Park, Shin-Young, Matte, Alessandro, Jung, Yookyung, Ryu, Jina, Anand, Wilson Babu, Han, Eun-Young, Liu, Min, Carbone, Carmine, Melisi, Davide, Nagasawa, Takashi, Locascio, Joseph J., Lin, Charles P., Silberstein, Leslie E., De Franceschi, Lucia
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 04.06.2020; American Society of Hematology
• Subjects: Anemia, Sickle Cell - complications; Animals; Blood Transfusion - methods; Bone Marrow - metabolism; Bone Marrow - pathology; Erythrocytes, Abnormal - metabolism; Erythrocytes, Abnormal - pathology; Female; Hematopoiesis; Humans; Male; Mice; Neovascularization, Pathologic - etiology; Neovascularization, Pathologic - pathology; Neovascularization, Pathologic - prevention & control; Red Cells, Iron, and Erythropoiesis; Splenomegaly - etiology; Splenomegaly - pathology; Splenomegaly - prevention & control

Sickle cell disease (SCD) is a monogenic red blood cell (RBC) disorder with high morbidity and mortality. Here, we report, for the first time, the impact of SCD on the bone marrow (BM) vascular niche, which is critical for hematopoiesis. In SCD mice, we find a disorganized and structurally abnormal...