The Lateral Habenula Circuitry: Reward Processing and Cognitive Control
There has been a growing interest in understanding the role of the lateral habenula (LHb) in reward processing, affect regulation, and goal-directed behaviors. The LHb gets major inputs from the habenula-projecting globus pallidus and the mPFC, sending its efferents to the dopaminergic VTA and SNc,...
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Published in | The Journal of neuroscience Vol. 36; no. 45; pp. 11482 - 11488 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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United States
Society for Neuroscience
09.11.2016
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Abstract | There has been a growing interest in understanding the role of the lateral habenula (LHb) in reward processing, affect regulation, and goal-directed behaviors. The LHb gets major inputs from the habenula-projecting globus pallidus and the mPFC, sending its efferents to the dopaminergic VTA and SNc, serotonergic dorsal raphe nuclei, and the GABAergic rostromedial tegmental nucleus. Recent studies have made advances in our understanding of the LHb circuit organization, yet the precise mechanisms of its involvement in complex behaviors are largely unknown. To begin to address this unresolved question, we present here emerging cross-species perspectives with a goal to provide a more refined understanding of the role of the LHb circuits in reward and cognition. We begin by highlighting recent findings from rodent experiments using optogenetics, electrophysiology, molecular, pharmacology, and tracing techniques that reveal diverse neural phenotypes in the LHb circuits that may underlie previously undescribed behavioral functions. We then discuss results from electrophysiological studies in macaques that suggest that the LHb cooperates with the anterior cingulate cortex to monitor action outcomes and signal behavioral adjustment. Finally, we provide an integrated summary of cross-species findings and discuss how further research on the connectivity, neural signaling, and physiology of the LHb circuits can deepen our understanding of the role of the LHb in normal and maladaptive behaviors associated with mental illnesses and drug abuse. |
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AbstractList | There has been a growing interest in understanding the role of the lateral habenula (LHb) in reward processing, affect regulation, and goal-directed behaviors. The LHb gets major inputs from the habenula-projecting globus pallidus and the mPFC, sending its efferents to the dopaminergic VTA and SNc, serotonergic dorsal raphe nuclei, and the GABAergic rostromedial tegmental nucleus. Recent studies have made advances in our understanding of the LHb circuit organization, yet the precise mechanisms of its involvement in complex behaviors are largely unknown. To begin to address this unresolved question, we present here emerging cross-species perspectives with a goal to provide a more refined understanding of the role of the LHb circuits in reward and cognition. We begin by highlighting recent findings from rodent experiments using optogenetics, electrophysiology, molecular, pharmacology, and tracing techniques that reveal diverse neural phenotypes in the LHb circuits that may underlie previously undescribed behavioral functions. We then discuss results from electrophysiological studies in macaques that suggest that the LHb cooperates with the anterior cingulate cortex to monitor action outcomes and signal behavioral adjustment. Finally, we provide an integrated summary of cross-species findings and discuss how further research on the connectivity, neural signaling, and physiology of the LHb circuits can deepen our understanding of the role of the LHb in normal and maladaptive behaviors associated with mental illnesses and drug abuse. |
Author | Li, Bo Vicentic, Aleksandra Matsumoto, Masayuki Baker, Phillip M Jhou, Thomas Mizumori, Sheri J Y Stephenson-Jones, Marcus |
Author_xml | – sequence: 1 givenname: Phillip M orcidid: 0000-0002-3023-2983 surname: Baker fullname: Baker, Phillip M organization: Department of Psychology, University of Washington, Seattle, Washington 98195-1525 – sequence: 2 givenname: Thomas surname: Jhou fullname: Jhou, Thomas organization: Medical University of South Carolina, Department of Neurosciences, Charleston, South Carolina 29425 – sequence: 3 givenname: Bo orcidid: 0000-0002-0154-3088 surname: Li fullname: Li, Bo email: vicentica@mail.nih.gov, bli@cshl.edu organization: Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, vicentica@mail.nih.gov bli@cshl.edu – sequence: 4 givenname: Masayuki surname: Matsumoto fullname: Matsumoto, Masayuki organization: Division of Biomedical Science, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8577, Japan, and – sequence: 5 givenname: Sheri J Y surname: Mizumori fullname: Mizumori, Sheri J Y organization: Department of Psychology, University of Washington, Seattle, Washington 98195-1525 – sequence: 6 givenname: Marcus surname: Stephenson-Jones fullname: Stephenson-Jones, Marcus organization: Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724 – sequence: 7 givenname: Aleksandra surname: Vicentic fullname: Vicentic, Aleksandra email: vicentica@mail.nih.gov, bli@cshl.edu organization: Division of Neuroscience and Basic Behavioral Science, National Institute of Mental Health, Rockville, Maryland 20892 vicentica@mail.nih.gov bli@cshl.edu |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27911751$$D View this record in MEDLINE/PubMed |
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Keywords | reward punishment cognition rostromedial tegmental nucleus globus pallidus anterior cingulate cortex lateral habenula |
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SubjectTerms | Animals Choice Behavior - physiology Cognition - physiology Evidence-Based Medicine Habenula - physiology Humans Macaca Models, Neurological Nerve Net - physiology Reward Symposium and Mini-Symposium |
Title | The Lateral Habenula Circuitry: Reward Processing and Cognitive Control |
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