Synthesis of 1,2,4-Oxadiazin-5(6H)-One Derivatives and Their Biological Investigation as Monoamine Oxidase Inhibitors

• Published in: Molecules (Basel, Switzerland) Vol. 29; no. 23; p. 5550
• Main Authors: Presnukhina, Sofia I., Kotlyarova, Valentina D., Shetnev, Anton A., Baykov, Sergey V., Turmanov, Rakhymzhan, Appazov, Nurbol, Zhapparbergenov, Rakhmetulla, Zhussupova, Leilya, Togyzbayeva, Nurila, Cloete, Stephanus J., Korsakov, Mikhail K., Boyarskiy, Vadim P., Petzer, Anél, Petzer, Jacobus P.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.12.2024; MDPI
• Subjects: Depression, Mental; Disease; Dopamine; Drug therapy; Humans; Hydrogen peroxide; inhibition; Investigations; MAO; Mental depression; Metabolism; Molecular Structure; monoamine oxidase; Monoamine Oxidase - metabolism; Monoamine Oxidase Inhibitors - chemical synthesis; Monoamine Oxidase Inhibitors - chemistry; Monoamine Oxidase Inhibitors - pharmacology; Nervous system diseases; Neurodegeneration; oxadiazine; Oxazines - chemical synthesis; Oxazines - chemistry; Oxazines - pharmacology; Oxidases; Oxidative stress; Parkinson Disease - drug therapy; Parkinson’s disease; Prostate cancer; Rasagiline; Reagents; Serotonin; Structure-Activity Relationship; oxadiazine; inhibition; MAO; Parkinson’s disease; monoamine oxidase

Monoamine oxidase (MAO) plays a key role in the pathogenesis of central nervous system disorders, and MAO inhibitors have been used in the treatment of depression and Parkinson’s disease. In the search for new classes of MAO inhibitors, the present study investigated a series of 1,2,4-oxadiazin-5(6H...