Identification of Lysine Acetylation Sites on MERS-CoV Replicase pp1ab

• Published in: Molecular & cellular proteomics Vol. 19; no. 8; pp. 1303 - 1309
• Main Authors: Zhu, Lin, Fung, Sin-Yee, Xie, Guangshan, Wong, Lok-Yin Roy, Jin, Dong-Yan, Cai, Zongwei
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2020; American Society for Biochemistry and Molecular Biology
• Subjects: Acetylation; bioinformatics; HEK293 Cells; Humans; immunoaffinity; Lysine - metabolism; MERS-CoV; Middle East Respiratory Syndrome Coronavirus - metabolism; post-translational modifications; Viral Proteins - metabolism; viruses; immunoaffinity; viruses; MERS-CoV; Acetylation; post-translational modifications; bioinformatics
• ISSN: 1535-9476; 1535-9484; 1535-9484
• DOI: 10.1074/mcp.RA119.001897

MERS is a life-threatening coronavirus and its mechanism is not clearly understood. In this study, acetylation events on MERS-CoV viral protein pp1ab were identified for the first time, which indicate that MERS-CoV might use the host acetylation machinery to regulate its enzyme activity and to achie...