Expression, activity, and localization of hormone-sensitive lipase in rat mammary gland during pregnancy and lactation

We examined the presence of hormone-sensitive lipase (HSL) in mammary glands of virgin, pregnant (12, 20, and 21 days), and lactating (1 and 4 days postpartum) rats. Immunohistochemistry with antibody against rat HSL revealed positive HSL in the cytoplasm of both alveolar epithelial cells and adipoc...

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Published inJournal of lipid research Vol. 46; no. 4; pp. 658 - 668
Main Authors Martín-Hidalgo, Antonia, Huerta, Lydia, Álvarez, Nieves, Alegría, Gemma, del Val Toledo, María, Herrera, Emilio
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.2005
Elsevier
Subjects
adipocytes
Adipocytes - cytology
Adipocytes - metabolism
Aging - physiology
Animals
diacylglycerol lipase
epithelial cells
Female
Immunohistochemistry
Insulin - blood
Lactation - genetics
Lactation - metabolism
Mammary Glands, Animal - enzymology
milk
Milk - metabolism
Pregnancy - genetics
Pregnancy - metabolism
Rats
Rats, Sprague-Dawley
RNA, Messenger - genetics
RNA, Messenger - metabolism
Sterol Esterase - genetics
Sterol Esterase - metabolism
milk
epithelial cells
immunohistochemistry
adipocytes
diacylglycerol lipase
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Abstract We examined the presence of hormone-sensitive lipase (HSL) in mammary glands of virgin, pregnant (12, 20, and 21 days), and lactating (1 and 4 days postpartum) rats. Immunohistochemistry with antibody against rat HSL revealed positive HSL in the cytoplasm of both alveolar epithelial cells and adipocytes. In virgin rats, immunoreactive HSL was observed in mammary adipocytes, whereas diffuse staining was found in the epithelial cells. Positive staining for HSL was seen in the two types of cells in pregnant and lactating rats. However, as pregnancy advanced, the staining intensity of immunoreactive HSL increased in the epithelial cells parallel to their proliferation, attaining the maximum during lactation. An immunoreactive protein of 84 kDa and a HSL mRNA of 3.3. kb were found in the rat mammary gland as in white adipose tissue. Both HSL protein and activity were lower in mammary glands from 20 and 21 day pregnant rats than from those of virgin rats, although they returned to virgin values on days 1 and 4 of lactation. Mammary gland HSL activity correlated negatively to plasma insulin levels. Immunoreactive HSL and HSL activity were found in lactating rats' milk. The observed changes indicate an active role of HSL in mammary gland lipid metabolism.
AbstractList We examined the presence of hormone-sensitive lipase (HSL) in mammary glands of virgin, pregnant (12, 20, and 21 days), and lactating (1 and 4 days postpartum) rats. Immunohistochemistry with antibody against rat HSL revealed positive HSL in the cytoplasm of both alveolar epithelial cells and adipocytes. In virgin rats, immunoreactive HSL was observed in mammary adipocytes, whereas diffuse staining was found in the epithelial cells. Positive staining for HSL was seen in the two types of cells in pregnant and lactating rats. However, as pregnancy advanced, the staining intensity of immunoreactive HSL increased in the epithelial cells parallel to their proliferation, attaining the maximum during lactation. An immunoreactive protein of 84 kDa and a HSL mRNA of 3.3. kb were found in the rat mammary gland as in white adipose tissue. Both HSL protein and activity were lower in mammary glands from 20 and 21 day pregnant rats than from those of virgin rats, although they returned to virgin values on days 1 and 4 of lactation. Mammary gland HSL activity correlated negatively to plasma insulin levels. Immunoreactive HSL and HSL activity were found in lactating rats' milk. The observed changes indicate an active role of HSL in mammary gland lipid metabolism.
We examined the presence of hormone-sensitive lipase (HSL) in mammary glands of virgin, pregnant (12, 20, and 21 days), and lactating (1 and 4 days postpartum) rats. Immunohistochemistry with antibody against rat HSL revealed positive HSL in the cytoplasm of both alveolar epithelial cells and adipocytes. In virgin rats, immunoreactive HSL was observed in mammary adipocytes, whereas diffuse staining was found in the epithelial cells. Positive staining for HSL was seen in the two types of cells in pregnant and lactating rats. However, as pregnancy advanced, the staining intensity of immunoreactive HSL increased in the epithelial cells parallel to their proliferation, attaining the maximum during lactation. An immunoreactive protein of 84 kDa and a HSL mRNA of 3.3. kb were found in the rat mammary gland as in white adipose tissue. Both HSL protein and activity were lower in mammary glands from 20 and 21 day pregnant rats than from those of virgin rats, although they returned to virgin values on days 1 and 4 of lactation. Mammary gland HSL activity correlated negatively to plasma insulin levels. Immunoreactive HSL and HSL activity were found in lactating rats' milk. The observed changes indicate an active role of HSL in mammary gland lipid metabolism.
Author Alegría, Gemma
Álvarez, Nieves
del Val Toledo, María
Huerta, Lydia
Herrera, Emilio
Martín-Hidalgo, Antonia
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Keywords milk
epithelial cells
immunohistochemistry
adipocytes
diacylglycerol lipase
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  article-title: Letting lipids go: hormone-sensitive lipase
  publication-title: Curr. Opin. Lipidol.
  contributor:
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Snippet We examined the presence of hormone-sensitive lipase (HSL) in mammary glands of virgin, pregnant (12, 20, and 21 days), and lactating (1 and 4 days postpartum)...
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SubjectTerms adipocytes
Adipocytes - cytology
Adipocytes - metabolism
Aging - physiology
Animals
diacylglycerol lipase
epithelial cells
Female
Immunohistochemistry
Insulin - blood
Lactation - genetics
Lactation - metabolism
Mammary Glands, Animal - enzymology
milk
Milk - metabolism
Pregnancy - genetics
Pregnancy - metabolism
Rats
Rats, Sprague-Dawley
RNA, Messenger - genetics
RNA, Messenger - metabolism
Sterol Esterase - genetics
Sterol Esterase - metabolism
Title Expression, activity, and localization of hormone-sensitive lipase in rat mammary gland during pregnancy and lactation
URI https://dx.doi.org/10.1194/jlr.M400370-JLR200
https://www.ncbi.nlm.nih.gov/pubmed/15654127
https://search.proquest.com/docview/67525880
https://doaj.org/article/a27ad9c61bf047e78216d8b1c99962db
Volume 46
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