Identification of SARS-CoV-2 Mpro inhibitors containing P1’ 4-fluorobenzothiazole moiety highly active against SARS-CoV-2 - Higashi-Kuwata, Nobuyo; Tsuji, Kohei; Hayashi, Hironori; Bulut, Haydar; Kiso, Maki; Imai, Masaki; Ogata-Aoki, Hiromi; Ishii, Takahiro; Kobayakawa, Takuya; Nakano, Kenta; Takamune, Nobutoki; Kishimoto, Naoki; et al. (Nature communications, 2023)
Keywords: 13; 14; 631/154/309; 631/326/22/1295; 631/326/596/4130; 631/45/468; ACE2; Amino acids; Angiotensin-converting enzyme 2; Antiviral agents; Antiviral drugs; Benzothiazole; Coronaviruses; Covalent bonds; COVID-19; Crystallography; Dimerization; Enzymatic activity; Fluorine; Humanities and Social Sciences; Infectivity; multidisciplinary; Optimization; Protease; Public health; Replication; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Spectrometry