The reduction in circulating levels of melatonin may be associated with the development of preeclampsia

• Published in: Journal of human hypertension Vol. 30; no. 11; pp. 666 - 671
• Main Authors: Zeng, K, Gao, Y, Wan, J, Tong, M, Lee, A C, Zhao, M, Chen, Q
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2016; Nature Publishing Group
• Subjects: 13/1; 13/106; 692/699/75/243; 692/699/75/243/793; Biomarkers - blood; China - epidemiology; Complications and side effects; Down-Regulation; Epidemiology; Female; Health Administration; Health aspects; Hospitals, Teaching; Humans; Hypertension; Incidence; Medicine; Medicine & Public Health; Melatonin; Melatonin - blood; Melatonin receptors; original-article; Oxidative stress; Placenta - metabolism; Pre-eclampsia; Pre-Eclampsia - blood; Pre-Eclampsia - diagnosis; Pre-Eclampsia - epidemiology; Pre-Eclampsia - physiopathology; Preeclampsia; Pregnancy; Pregnant women; Public Health; Receptor, Melatonin, MT1 - metabolism; Retrospective Studies; Risk Factors; Seasonal variations; Seasons; Serum levels

Placental dysfunction and oxidative stress contribute to the pathogenesis of preeclampsia, which is a pregnancy-specific disorder. It has been suggested that the incidence of preeclampsia has a seasonal variation. Melatonin, as a seasonal factor, has been suggested to be involved in a successful pre...