Robo2 contains a cryptic binding site for neural EGFL-like (NELL) protein 1/2

• Published in: The Journal of biological chemistry Vol. 294; no. 12; pp. 4693 - 4703
• Main Authors: Yamamoto, Naoka, Kashiwagi, Manabu, Ishihara, Manami, Kojima, Takaaki, Maturana, Andrés D., Kuroda, Shun’ichi, Niimi, Tomoaki
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 22.03.2019; American Society for Biochemistry and Molecular Biology
• Subjects: Acids; Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Calcium-Binding Proteins; cell surface receptor; Humans; Hydrogen-Ion Concentration; Mutation; Nerve Tissue Proteins - metabolism; protein conformation; protein domain; Protein Structure and Folding; protein-protein interaction; Proteolysis; Receptors, Immunologic - chemistry; Receptors, Immunologic - genetics; Receptors, Immunologic - metabolism; structural model; protein domain; protein conformation; protein-protein interaction; cell surface receptor; structural model

The signaling pathways that are mediated by Slit ligands and their Roundabout (Robo) family of receptors play multifunctional roles in the development of the nervous system and other organs. A recent study identified neural epidermal growth factor–like (NEL)–like 2 (NELL2) as a novel ligand for Robo...