Prolonged survival of renal cancer patients is concomitant with a higher regucalcin gene expression in tumor tissues: Overexpression of regucalcin suppresses the growth of human renal cell carcinoma cells in vitro

• Published in: International journal of oncology Vol. 54; no. 1; pp. 188 - 198
• Main Authors: Yamaguchi, Masayoshi, Osuka, Satoru, Hankinson, Oliver, Murata, Tomiyasu
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.01.2019; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Breast cancer; Calcium binding proteins; Calcium-Binding Proteins - genetics; Cancer genetics; Cancer research; Carcinoma, Renal Cell - genetics; Cell cycle; Cell Cycle Checkpoints; Cell death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colorectal cancer; Deoxyribonucleic acid; DNA; Female; Gene expression; Gene Expression Regulation, Neoplastic; Genetic aspects; Growth factors; Health aspects; Homeostasis; Human subjects; Humans; Hypertension; In Vitro Techniques; Intracellular Signaling Peptides and Proteins - genetics; Kidney cancer; Kidney Neoplasms - genetics; Kinases; Liver cancer; Medical prognosis; Pancreatic cancer; Patient outcomes; Physiological aspects; Proteins; Renal cell carcinoma; RNA polymerase; Rodents; Signal Transduction; Survival Analysis; Transcription factors; Tumor necrosis factor-TNF; Up-Regulation; United States > US

Renal cell carcinoma (RCC), which is a type of cancer found in the kidney tubule, is among the 10 most frequently occurring human cancers. Regucalcin plays a potential role as a regulator of transcriptional activity, and its downregulated expression or activity may contribute to the promotion of hum...