Facilitation of corticostriatal transmission following pharmacological inhibition of striatal phosphodiesterase 10A: role of nitric oxide-soluble guanylyl cyclase-cGMP signaling pathways

• Published in: The Journal of neuroscience Vol. 35; no. 14; pp. 5781 - 5791
• Main Authors: Padovan-Neto, Fernando E, Sammut, Stephen, Chakroborty, Shreaya, Dec, Alexander M, Threlfell, Sarah, Campbell, Peter W, Mudrakola, Vishnu, Harms, John F, Schmidt, Christopher J, West, Anthony R
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 08.04.2015
• Subjects: Action Potentials - drug effects; Action Potentials - genetics; Animals; Biophysics; Cerebral Cortex - cytology; Corpus Striatum - cytology; Corpus Striatum - drug effects; Cyclic AMP - metabolism; Cyclic GMP - metabolism; Electric Stimulation; Enzyme Inhibitors - pharmacology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Neural Pathways - drug effects; Neural Pathways - physiology; Neurons - drug effects; Nitric Oxide Synthase Type I - genetics; Nitric Oxide Synthase Type I - metabolism; Phosphoric Diester Hydrolases - metabolism; Rats; Rats, Sprague-Dawley; Signal Transduction - physiology; phosphodiesterase 10A; cGMP; nitric oxide; medium-sized spiny neuron; nitric oxide synthase; soluble guanylyl cyclase

The striatum contains a rich variety of cyclic nucleotide phosphodiesterases (PDEs), which play a critical role in the regulation of cAMP and cGMP signaling. The dual-substrate enzyme PDE10A is the most highly expressed PDE in striatal medium-sized spiny neurons (MSNs) with low micromolar affinity f...