Biological Potential and Bioaccessibility of Encapsulated Curcumin into Cetyltrimethylammonium Bromide Modified Cellulose Nanocrystals

Curcumin is a natural phenolic compound with important biological functions. Despite its demonstrated efficacy in vitro, curcumin biological activities in vivo are dependent on its bioaccessibility and bioavailability, which have been highlighted as a crucial challenge. Cetyltrimethylammonium bromid...

Full description

Saved in:
Bibliographic Details
Published inPharmaceuticals (Basel, Switzerland) Vol. 16; no. 12; p. 1737
Main Authors Casanova, Francisca, Pereira, Carla F., Ribeiro, Alessandra B., Castro, Pedro M., Freixo, Ricardo, Martins, Eva, Tavares-Valente, Diana, Fernandes, João C., Pintado, Manuela E., Ramos, Óscar L.
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.12.2023
Subjects
Anti-inflammatory drugs
Antioxidants
Bioavailability
Biological activity
biological potential
Cellulose
Chemical properties
CNC-CTAB
curcumin
Cytotoxicity
delivery system
Dosage and administration
Free radicals
Health aspects
Inflammation
intestinal permeability
Metabolism
Nanocrystals
Nanomaterials
Particle size
Permeability
Structure
Surfactants
Testing
Turmeric
Portugal
United Kingdom
Massachusetts
biological potential
delivery system
intestinal permeability
CNC-CTAB
curcumin
Online AccessGet full text

Cover

Abstract Curcumin is a natural phenolic compound with important biological functions. Despite its demonstrated efficacy in vitro, curcumin biological activities in vivo are dependent on its bioaccessibility and bioavailability, which have been highlighted as a crucial challenge. Cetyltrimethylammonium bromide-modified cellulose nanocrystals (CNC-CTAB) have been shown to be effective in curcumin encapsulation, as they have the potential to enhance biological outcomes. This study evaluated the biological effects of curcumin encapsulated within CNC-CTAB structures, namely its antioxidant, anti-inflammatory and antimicrobial properties, as well as the release profile under digestion conditions and intestinal permeability. Encapsulated curcumin demonstrated antioxidant and anti-inflammatory properties, effectively reducing reactive oxygen species and cytokine production by intestinal cells. The delivery system exhibited antimicrobial properties against Campylobacter jejuni bacteria, further suggesting its potential in mitigating intestinal inflammation. The system showed the ability to protect curcumin from degradation and facilitate its interaction with the intestinal epithelium, highlighting the potential of CNC-CTAB as carrier to enhance curcumin intestinal biological functions.
AbstractList Curcumin is a natural phenolic compound with important biological functions. Despite its demonstrated efficacy in vitro, curcumin biological activities in vivo are dependent on its bioaccessibility and bioavailability, which have been highlighted as a crucial challenge. Cetyltrimethylammonium bromide-modified cellulose nanocrystals (CNC-CTAB) have been shown to be effective in curcumin encapsulation, as they have the potential to enhance biological outcomes. This study evaluated the biological effects of curcumin encapsulated within CNC-CTAB structures, namely its antioxidant, anti-inflammatory and antimicrobial properties, as well as the release profile under digestion conditions and intestinal permeability. Encapsulated curcumin demonstrated antioxidant and anti-inflammatory properties, effectively reducing reactive oxygen species and cytokine production by intestinal cells. The delivery system exhibited antimicrobial properties against Campylobacter jejuni bacteria, further suggesting its potential in mitigating intestinal inflammation. The system showed the ability to protect curcumin from degradation and facilitate its interaction with the intestinal epithelium, highlighting the potential of CNC-CTAB as carrier to enhance curcumin intestinal biological functions.
Curcumin is a natural phenolic compound with important biological functions. Despite its demonstrated efficacy in vitro, curcumin biological activities in vivo are dependent on its bioaccessibility and bioavailability, which have been highlighted as a crucial challenge. Cetyltrimethylammonium bromide-modified cellulose nanocrystals (CNC-CTAB) have been shown to be effective in curcumin encapsulation, as they have the potential to enhance biological outcomes. This study evaluated the biological effects of curcumin encapsulated within CNC-CTAB structures, namely its antioxidant, anti-inflammatory and antimicrobial properties, as well as the release profile under digestion conditions and intestinal permeability. Encapsulated curcumin demonstrated antioxidant and anti-inflammatory properties, effectively reducing reactive oxygen species and cytokine production by intestinal cells. The delivery system exhibited antimicrobial properties against Campylobacter jejuni bacteria, further suggesting its potential in mitigating intestinal inflammation. The system showed the ability to protect curcumin from degradation and facilitate its interaction with the intestinal epithelium, highlighting the potential of CNC-CTAB as carrier to enhance curcumin intestinal biological functions.Curcumin is a natural phenolic compound with important biological functions. Despite its demonstrated efficacy in vitro, curcumin biological activities in vivo are dependent on its bioaccessibility and bioavailability, which have been highlighted as a crucial challenge. Cetyltrimethylammonium bromide-modified cellulose nanocrystals (CNC-CTAB) have been shown to be effective in curcumin encapsulation, as they have the potential to enhance biological outcomes. This study evaluated the biological effects of curcumin encapsulated within CNC-CTAB structures, namely its antioxidant, anti-inflammatory and antimicrobial properties, as well as the release profile under digestion conditions and intestinal permeability. Encapsulated curcumin demonstrated antioxidant and anti-inflammatory properties, effectively reducing reactive oxygen species and cytokine production by intestinal cells. The delivery system exhibited antimicrobial properties against Campylobacter jejuni bacteria, further suggesting its potential in mitigating intestinal inflammation. The system showed the ability to protect curcumin from degradation and facilitate its interaction with the intestinal epithelium, highlighting the potential of CNC-CTAB as carrier to enhance curcumin intestinal biological functions.
Curcumin is a natural phenolic compound with important biological functions. Despite its demonstrated efficacy in vitro, curcumin biological activities in vivo are dependent on its bioaccessibility and bioavailability, which have been highlighted as a crucial challenge. Cetyltrimethylammonium bromide-modified cellulose nanocrystals (CNC-CTAB) have been shown to be effective in curcumin encapsulation, as they have the potential to enhance biological outcomes. This study evaluated the biological effects of curcumin encapsulated within CNC-CTAB structures, namely its antioxidant, anti-inflammatory and antimicrobial properties, as well as the release profile under digestion conditions and intestinal permeability. Encapsulated curcumin demonstrated antioxidant and anti-inflammatory properties, effectively reducing reactive oxygen species and cytokine production by intestinal cells. The delivery system exhibited antimicrobial properties against bacteria, further suggesting its potential in mitigating intestinal inflammation. The system showed the ability to protect curcumin from degradation and facilitate its interaction with the intestinal epithelium, highlighting the potential of CNC-CTAB as carrier to enhance curcumin intestinal biological functions.
Audience Academic
Author Castro, Pedro M.
Fernandes, João C.
Martins, Eva
Pereira, Carla F.
Ribeiro, Alessandra B.
Tavares-Valente, Diana
Pintado, Manuela E.
Casanova, Francisca
Freixo, Ricardo
Ramos, Óscar L.
Author_xml – sequence: 1
  givenname: Francisca
  surname: Casanova
  fullname: Casanova, Francisca
– sequence: 2
  givenname: Carla F.
  surname: Pereira
  fullname: Pereira, Carla F.
– sequence: 3
  givenname: Alessandra B.
  orcidid: 0000-0003-3822-8601
  surname: Ribeiro
  fullname: Ribeiro, Alessandra B.
– sequence: 4
  givenname: Pedro M.
  orcidid: 0000-0001-7164-8005
  surname: Castro
  fullname: Castro, Pedro M.
– sequence: 5
  givenname: Ricardo
  surname: Freixo
  fullname: Freixo, Ricardo
– sequence: 6
  givenname: Eva
  orcidid: 0000-0003-1498-1893
  surname: Martins
  fullname: Martins, Eva
– sequence: 7
  givenname: Diana
  surname: Tavares-Valente
  fullname: Tavares-Valente, Diana
– sequence: 8
  givenname: João C.
  surname: Fernandes
  fullname: Fernandes, João C.
– sequence: 9
  givenname: Manuela E.
  orcidid: 0000-0002-0760-3184
  surname: Pintado
  fullname: Pintado, Manuela E.
– sequence: 10
  givenname: Óscar L.
  surname: Ramos
  fullname: Ramos, Óscar L.
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38139863$$D View this record in MEDLINE/PubMed
BookMark eNptksluFDEQQFsoiCxw4QNQS1yiSBO8ddt9TEYJRArLAc6Wt57UyG0PtvswP8B342ESCFHkQ1nlV69cUh03ByEG1zRvMTqndEAfNne4xwRzyl80R5gRthCE8YNH98PmOOc1Qh3HDL9qDqnAdBA9PWp-XUL0cQVG-fZbLC4UqDcVbFsflDEuZ9DgoWzbOLZXwahNnr0qzrbLOZl5gtBCKLFdurL1JcHkyt3Wq2mKAeapvUxxAuvaz9HCCLsq5_3sY3btFxWiSdtclM-vm5djDe7NfTxpflxffV9-Wtx-_XizvLhdmA7TsmBjbwUyneYIcax6LKgmGhGBNFEKYYuJdsxyowbXc0d7bLtBC455L3qkBT1pbvZeG9Vabup3VdrKqED-ScS0kioVMN5JPVrrLHFqQJQhNghjqpQQoXT14b66TveuTYo_Z5eLnCCbOp4KLs5ZkgF1Hem5GCr6_gm6jnMKddIdxQTvGH5ErVTtD2GMJSmzk8oLzgeCWdVV6vwZqh7rJjB1M0ao-f8K3t03n_Xk7N-pH5agAmgPmBRzTm6UBooqEEM1g5cYyd2eyX97VkvOnpQ8WJ-BfwMVcdIP
CitedBy_id crossref_primary_10_1016_j_xphs_2025_103701
crossref_primary_10_3390_life14091138
crossref_primary_10_3390_app142210416
Cites_doi 10.1016/j.ijpharm.2012.03.031
10.1021/ja003823x
10.1152/ajpgi.00193.2009
10.1021/mp700113r
10.1016/j.colsurfb.2015.11.039
10.1007/978-0-387-46401-5_21
10.1039/C3FO60702J
10.1016/j.pupt.2021.102047
10.1016/j.molliq.2020.112479
10.1042/bj20021619
10.1016/j.ejpb.2010.12.006
10.1016/j.ejpb.2017.04.004
10.1039/c3fo60180c
10.1002/anie.201107724
10.33988/auvfd.911244
10.1016/j.ijbiomac.2020.06.188
10.1017/S0007114510004356
10.1111/jfs.12353
10.1016/j.jfca.2006.01.003
10.1371/journal.pone.0174441
10.1016/j.carbpol.2017.01.036
10.1016/j.fochx.2019.100006
10.1002/ijc.23477
10.1016/j.powtec.2016.04.014
10.3390/pharmaceutics15030981
10.3390/polym9020064
10.1007/978-3-319-16104-4_10
10.3390/gels9080596
10.1016/j.msec.2020.111793
10.1007/s11274-018-2472-1
10.1016/j.ejpb.2012.10.003
10.1016/j.bmcl.2015.12.060
10.1016/j.jtcme.2016.05.005
10.1016/j.jddst.2019.101314
10.38212/2224-6614.3454
10.1089/ten.tea.2016.0268
10.3390/polym15102408
10.1248/bpb.34.226
10.1016/j.actbio.2017.10.017
10.3390/app11219849
10.1136/gut.39.5.684
10.3390/ijms23147929
10.17221/8880-VETMED
10.1016/j.bcp.2005.04.043
10.1016/j.ijbiomac.2019.12.247
10.1002/app.44789
10.1080/10408398.2022.2070906
10.1016/j.ijbiomac.2019.07.035
10.3109/09637486.2015.1077792
10.1016/j.bpj.2021.12.018
10.1016/j.carbpol.2019.115745
10.3390/molecules191220091
10.3389/fimmu.2017.01411
10.1074/jbc.270.42.24995
10.1158/1078-0432.CCR-04-0744
10.1155/2014/186864
10.1080/10408398.2018.1495174
10.1016/j.jff.2015.01.043
10.1038/s41596-018-0119-1
10.1182/blood-2002-05-1320
10.1177/0748233713498458
10.3390/antiox4040750
10.1016/j.ijpharm.2017.09.064
10.3390/antibiotics11030322
10.3390/nano11102593
10.1016/S0169-409X(01)00115-6
10.1021/am505681e
10.1016/j.bcp.2007.08.016
10.1007/s10570-017-1646-6
ContentType Journal Article
Copyright COPYRIGHT 2023 MDPI AG
2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: COPYRIGHT 2023 MDPI AG
– notice: 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID AAYXX
CITATION
NPM
3V.
7XB
8FK
8G5
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
GNUQQ
GUQSH
M2O
MBDVC
PHGZM
PHGZT
PIMPY
PKEHL
PQEST
PQQKQ
PQUKI
Q9U
7X8
DOA
DOI 10.3390/ph16121737
DatabaseName CrossRef
PubMed
ProQuest Central (Corporate)
ProQuest Central (purchase pre-March 2016)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Research Library
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One
ProQuest Central
ProQuest Central Student
ProQuest Research Library
ProQuest Research Library
Research Library (Corporate)
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central Basic
MEDLINE - Academic
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
PubMed
Publicly Available Content Database
Research Library Prep
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Basic
ProQuest Central Essentials
ProQuest One Academic Eastern Edition
ProQuest Central (Alumni Edition)
ProQuest One Community College
Research Library (Alumni Edition)
ProQuest Central
ProQuest One Academic UKI Edition
ProQuest Central Korea
ProQuest Research Library
ProQuest Central (New)
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList Publicly Available Content Database

MEDLINE - Academic
PubMed

CrossRef
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Pharmacy, Therapeutics, & Pharmacology
EISSN 1424-8247
ExternalDocumentID oai_doaj_org_article_bfdded2ea90340498cc9e6228ab71716
A779214526
38139863
10_3390_ph16121737
Genre Journal Article
GeographicLocations Portugal
United Kingdom
Massachusetts
GeographicLocations_xml – name: Portugal
– name: United Kingdom
– name: Massachusetts
GrantInformation_xml – fundername: European Regional Development Fund
  grantid: POCI-01-0247-FEDER-027578
– fundername: Fundação para a Ciência e Tecnologia
  grantid: UID/Multi/50016/2020
GroupedDBID ---
2WC
53G
5VS
8G5
AADQD
AAFWJ
AAYXX
ABDBF
ABUWG
ACGFO
ACIHN
ACUHS
ADBBV
AEAQA
AFKRA
AFPKN
AFZYC
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BCNDV
BENPR
BPHCQ
CCPQU
CITATION
DIK
DWQXO
EBD
ESX
GNUQQ
GROUPED_DOAJ
GUQSH
GX1
HH5
HYE
IAO
IHR
ITC
KQ8
M2O
M48
MK0
MODMG
M~E
OK1
P2P
PGMZT
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
RPM
TUS
NPM
PMFND
3V.
7XB
8FK
MBDVC
PKEHL
PQEST
PQUKI
Q9U
7X8
PUEGO
ID FETCH-LOGICAL-c513t-4f6d80c5b70071a6183b2b0280b2aa01d12be4d7ca9e67e361d59b87176860b83
IEDL.DBID M48
ISSN 1424-8247
IngestDate Wed Aug 27 01:30:17 EDT 2025
Fri Jul 11 05:27:46 EDT 2025
Mon Jun 30 14:55:56 EDT 2025
Tue Jun 17 22:22:34 EDT 2025
Tue Jun 10 21:14:37 EDT 2025
Mon Jul 21 05:31:08 EDT 2025
Tue Jul 01 04:13:45 EDT 2025
Thu Apr 24 22:50:36 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 12
Keywords biological potential
delivery system
intestinal permeability
CNC-CTAB
curcumin
Language English
License https://creativecommons.org/licenses/by/4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c513t-4f6d80c5b70071a6183b2b0280b2aa01d12be4d7ca9e67e361d59b87176860b83
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0003-1498-1893
0000-0003-3822-8601
0000-0001-7164-8005
0000-0002-0760-3184
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.3390/ph16121737
PMID 38139863
PQID 2904875419
PQPubID 2032350
ParticipantIDs doaj_primary_oai_doaj_org_article_bfdded2ea90340498cc9e6228ab71716
proquest_miscellaneous_2905526789
proquest_journals_2904875419
gale_infotracmisc_A779214526
gale_infotracacademiconefile_A779214526
pubmed_primary_38139863
crossref_citationtrail_10_3390_ph16121737
crossref_primary_10_3390_ph16121737
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2023-12-01
PublicationDateYYYYMMDD 2023-12-01
PublicationDate_xml – month: 12
  year: 2023
  text: 2023-12-01
  day: 01
PublicationDecade 2020
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
– name: Basel
PublicationTitle Pharmaceuticals (Basel, Switzerland)
PublicationTitleAlternate Pharmaceuticals (Basel)
PublicationYear 2023
Publisher MDPI AG
Publisher_xml – name: MDPI AG
References Samad (ref_69) 2022; 121
No (ref_55) 2017; 37
Sharma (ref_46) 2019; 54
Atanase (ref_59) 2020; 147
ref_12
Bespalova (ref_53) 2017; 134
ref_11
Brodkorb (ref_57) 2019; 14
ref_54
Coscueta (ref_71) 2019; 1
Aguilar (ref_47) 2021; 121
Goel (ref_5) 2008; 75
Schrader (ref_34) 2011; 105
ref_18
Amalraj (ref_3) 2017; 7
Balogun (ref_35) 2003; 371
Zainuddin (ref_15) 2017; 163
Kolakovic (ref_25) 2012; 430
Foo (ref_16) 2019; 138
Svagan (ref_60) 2017; 533
Gunes (ref_50) 2016; 32
Pan (ref_65) 2015; 66
ref_23
ref_21
Ameruoso (ref_45) 2017; 8
Hsu (ref_4) 2023; 31
Chen (ref_8) 2001; 21
Priyadarsini (ref_32) 2014; 19
Zhong (ref_40) 2011; 34
ref_27
Sampath (ref_36) 2020; 162
Wahlang (ref_61) 2011; 77
ref_72
Anand (ref_10) 2007; 4
Madhavi (ref_1) 2014; 13
Mohanta (ref_17) 2014; 6
Nikolic (ref_30) 2020; 301
Jovanovic (ref_33) 2001; 123
Reimund (ref_39) 1996; 39
Akbari (ref_70) 2017; 64
ref_74
Omidi (ref_13) 2020; 231
Hsu (ref_7) 2007; 595
Minekus (ref_58) 2014; 5
Madureira (ref_67) 2016; 139
Schaich (ref_31) 2015; 14
ref_38
Mo (ref_20) 2017; 23
ref_37
Shishodia (ref_42) 2005; 70
Horniman (ref_62) 2021; 69
Bharti (ref_43) 2003; 101
Choudhury (ref_29) 2015; 4
Singh (ref_44) 1995; 270
Issa (ref_52) 2016; 61
Rashwan (ref_64) 2022; 63
Esatbeyoglu (ref_26) 2012; 51
Guri (ref_66) 2013; 4
Sharma (ref_9) 2004; 10
Keyvan (ref_51) 2022; 69
Rafiee (ref_2) 2019; 59
Mackenzie (ref_41) 2008; 123
Zeng (ref_63) 2017; 117
Botrel (ref_24) 2020; 44
Antunes (ref_73) 2013; 83
Casanova (ref_22) 2016; 297
Thaipong (ref_28) 2006; 19
ref_49
Ntoutoume (ref_19) 2016; 26
ref_48
Kalischuk (ref_56) 2010; 298
Khanvilkar (ref_68) 2001; 48
Serda (ref_6) 2003; 23
Tabary (ref_14) 2018; 25
References_xml – volume: 430
  start-page: 47
  year: 2012
  ident: ref_25
  article-title: Spray-Dried Nanofibrillar Cellulose Microparticles for Sustained Drug Release
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2012.03.031
– volume: 123
  start-page: 3064
  year: 2001
  ident: ref_33
  article-title: How Curcumin Works Preferentially with Water Soluble Antioxidants
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja003823x
– volume: 298
  start-page: G1
  year: 2010
  ident: ref_56
  article-title: A Role for Campylobacter Jejuni-Induced Enteritis in Inflammatory Bowel Disease?
  publication-title: Am. J. Physiol.—Gastrointest. Liver Physiol.
  doi: 10.1152/ajpgi.00193.2009
– volume: 4
  start-page: 807
  year: 2007
  ident: ref_10
  article-title: Bioavailability of Curcumin: Problems and Promises
  publication-title: Mol. Pharm.
  doi: 10.1021/mp700113r
– volume: 139
  start-page: 277
  year: 2016
  ident: ref_67
  article-title: Insights into the Protective Role of Solid Lipid Nanoparticles on Rosmarinic Acid Bioactivity during Exposure to Simulated Gastrointestinal Conditions
  publication-title: Colloids Surf. B Biointerfaces
  doi: 10.1016/j.colsurfb.2015.11.039
– volume: 595
  start-page: 471
  year: 2007
  ident: ref_7
  article-title: Clinical Studies with Curcumin
  publication-title: Adv. Exp. Med. Biol.
  doi: 10.1007/978-0-387-46401-5_21
– volume: 5
  start-page: 1113
  year: 2014
  ident: ref_58
  article-title: A Standardised Static in Vitro Digestion Method Suitable for Food-an International Consensus
  publication-title: Food Funct.
  doi: 10.1039/C3FO60702J
– volume: 69
  start-page: 102047
  year: 2021
  ident: ref_62
  article-title: The Anti-Inflammatory Effects of Cannabidiol and Cannabigerol Alone, and in Combination
  publication-title: Pulm. Pharmacol. Ther.
  doi: 10.1016/j.pupt.2021.102047
– volume: 301
  start-page: 112479
  year: 2020
  ident: ref_30
  article-title: Curcumin-Loaded Low-Energy Nanoemulsions: Linking EPR Spectroscopy-Analysed Microstructure and Antioxidant Potential with in Vitro Evaluated Biological Activity
  publication-title: J. Mol. Liq.
  doi: 10.1016/j.molliq.2020.112479
– volume: 371
  start-page: 887
  year: 2003
  ident: ref_35
  article-title: Curcumin Activates the Haem Oxygenase-1 Gene via Regulation of Nrf2 and the Antioxidant-Responsive Element
  publication-title: Biochem. J.
  doi: 10.1042/bj20021619
– ident: ref_23
– volume: 77
  start-page: 275
  year: 2011
  ident: ref_61
  article-title: Identification of Permeability-Related Hurdles in Oral Delivery of Curcumin Using the Caco-2 Cell Model
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/j.ejpb.2010.12.006
– volume: 117
  start-page: 123
  year: 2017
  ident: ref_63
  article-title: Transport of Curcumin Derivatives in Caco-2 Cell Monolayers
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/j.ejpb.2017.04.004
– volume: 4
  start-page: 1410
  year: 2013
  ident: ref_66
  article-title: Utilization of Solid Lipid Nanoparticles for Enhanced Delivery of Curcumin in Cocultures of HT29-MTX and Caco-2 Cells
  publication-title: Food Funct.
  doi: 10.1039/c3fo60180c
– volume: 51
  start-page: 5308
  year: 2012
  ident: ref_26
  article-title: Curcumin—From Molecule to Biological Function
  publication-title: Angew. Chem. Int. Ed.
  doi: 10.1002/anie.201107724
– volume: 69
  start-page: 355
  year: 2022
  ident: ref_51
  article-title: Determination of Time Dependent Antibacterial Activities of Curcumin, Carvacrol and Styrax Liquidus on Salmonella Enteritidis
  publication-title: Ank. Üniv. Vet. Fak. Derg.
  doi: 10.33988/auvfd.911244
– volume: 21
  start-page: 2895
  year: 2001
  ident: ref_8
  article-title: Phase I Clinical Trial of Curcumin, a Chemopreventive Agent, in Patients with High-Risk or Pre-Malignant Lesions
  publication-title: Anticancer Res.
– volume: 162
  start-page: 748
  year: 2020
  ident: ref_36
  article-title: The Remarkable Role of Emulsifier and Chitosan, Dextran and PEG as Capping Agents in the Enhanced Delivery of Curcumin by Nanoparticles in Breast Cancer Cells
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2020.06.188
– volume: 105
  start-page: 167
  year: 2011
  ident: ref_34
  article-title: Curcumin Induces Paraoxonase 1 in Cultured Hepatocytes in Vitro but Not in Mouse Liver in Vivo
  publication-title: Br. J. Nutr.
  doi: 10.1017/S0007114510004356
– volume: 37
  start-page: e12353
  year: 2017
  ident: ref_55
  article-title: Antimicrobial Efficacy of Curcumin Nanoparticles against Listeria Monocytogenes Is Mediated by Surface Charge
  publication-title: J. Food Saf.
  doi: 10.1111/jfs.12353
– volume: 19
  start-page: 669
  year: 2006
  ident: ref_28
  article-title: Comparison of ABTS, DPPH, FRAP, and ORAC Assays for Estimating Antioxidant Activity from Guava Fruit Extracts
  publication-title: J. Food Compos. Anal.
  doi: 10.1016/j.jfca.2006.01.003
– ident: ref_37
  doi: 10.1371/journal.pone.0174441
– volume: 163
  start-page: 261
  year: 2017
  ident: ref_15
  article-title: Hydrophobic Kenaf Nanocrystalline Cellulose for the Binding of Curcumin
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2017.01.036
– volume: 1
  start-page: 100006
  year: 2019
  ident: ref_71
  article-title: Enzymatic Soy Protein Hydrolysis: A Tool for Biofunctional Food Ingredient Production
  publication-title: Food Chem. X
  doi: 10.1016/j.fochx.2019.100006
– volume: 123
  start-page: 56
  year: 2008
  ident: ref_41
  article-title: Curcumin Induces Cell-Arrest and Apoptosis in Association with the Inhibition of Constitutively Active NF-ΚB and STAT3 Pathways in Hodgkin’s Lymphoma Cells
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.23477
– volume: 13
  start-page: 24
  year: 2014
  ident: ref_1
  article-title: Bioavailability of a Sustained Release Formulation of Curcumin
  publication-title: Integr. Med.
– volume: 297
  start-page: 44
  year: 2016
  ident: ref_22
  article-title: Preliminary Studies of Rosmarinic Acid Microencapsulation with Chitosan and Modified Chitosan for Topical Delivery
  publication-title: Powder Technol.
  doi: 10.1016/j.powtec.2016.04.014
– ident: ref_21
  doi: 10.3390/pharmaceutics15030981
– ident: ref_18
  doi: 10.3390/polym9020064
– ident: ref_72
  doi: 10.1007/978-3-319-16104-4_10
– volume: 23
  start-page: 363
  year: 2003
  ident: ref_6
  article-title: Anticancer Potential of Curcumin: Preclinical and Clinical Studies
  publication-title: Anticancer Res.
– ident: ref_11
  doi: 10.3390/gels9080596
– volume: 121
  start-page: 111793
  year: 2021
  ident: ref_47
  article-title: Amphiphilic Polymeric Nanoparticles Encapsulating Curcumin: Antioxidant, Anti-Inflammatory and Biocompatibility Studies
  publication-title: Mater. Sci. Eng. C
  doi: 10.1016/j.msec.2020.111793
– ident: ref_54
  doi: 10.1007/s11274-018-2472-1
– volume: 83
  start-page: 427
  year: 2013
  ident: ref_73
  article-title: Establishment of a Triple Co-Culture in Vitro Cell Models to Study Intestinal Absorption of Peptide Drugs
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/j.ejpb.2012.10.003
– volume: 26
  start-page: 941
  year: 2016
  ident: ref_19
  article-title: Development of Curcumin-Cyclodextrin/Cellulose Nanocrystals Complexes: New Anticancer Drug Delivery Systems
  publication-title: Bioorganic Med. Chem. Lett.
  doi: 10.1016/j.bmcl.2015.12.060
– volume: 7
  start-page: 205
  year: 2017
  ident: ref_3
  article-title: Biological Activities of Curcuminoids, Other Biomolecules from Turmeric and Their Derivatives—A Review
  publication-title: J. Tradit. Complement. Med.
  doi: 10.1016/j.jtcme.2016.05.005
– volume: 54
  start-page: 101314
  year: 2019
  ident: ref_46
  article-title: In-Vitro Studies of Curcumin Encapsulated Mesoporous Fe-Phenanthroline Nanocluster for Reduction of Amyloid β Plaque
  publication-title: J. Drug Deliv. Sci. Technol.
  doi: 10.1016/j.jddst.2019.101314
– volume: 31
  start-page: 194
  year: 2023
  ident: ref_4
  article-title: The Therapeutic Potential of Curcumin and Its Related Substances in Turmeric: From Raw Material Selection to Application Strategies
  publication-title: J. Food Drug Anal.
  doi: 10.38212/2224-6614.3454
– volume: 23
  start-page: 597
  year: 2017
  ident: ref_20
  article-title: Controlled Dual Delivery of Angiogenin and Curcumin by Electrospun Nanofibers for Skin Regeneration
  publication-title: Tissue Eng.—Part A
  doi: 10.1089/ten.tea.2016.0268
– ident: ref_38
  doi: 10.3390/polym15102408
– volume: 34
  start-page: 226
  year: 2011
  ident: ref_40
  article-title: Curcumin Attenuates Lipopolysaccharide-Induced Renal Inflammation
  publication-title: Biol. Pharm. Bull.
  doi: 10.1248/bpb.34.226
– volume: 64
  start-page: 249
  year: 2017
  ident: ref_70
  article-title: Interaction of Cruciferin-Based Nanoparticles with Caco-2 Cells and Caco-2/HT29-MTX Co-Cultures
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2017.10.017
– ident: ref_74
  doi: 10.3390/app11219849
– volume: 39
  start-page: 684
  year: 1996
  ident: ref_39
  article-title: Increased Production of Tumour Necrosis Factor-Alpha Interleukin-1 Beta, and Interleukin-6 by Morphologically Normal Intestinal Biopsies from Patients with Crohn’s Disease
  publication-title: Gut
  doi: 10.1136/gut.39.5.684
– ident: ref_27
  doi: 10.3390/ijms23147929
– volume: 61
  start-page: 256
  year: 2016
  ident: ref_52
  article-title: Antimicrobial Effects of Curcumin against L. Monocytogenes, S. Aureus, S. Typhimurium and E. coli O157:H7 Pathogens in Minced Meat
  publication-title: Vet. Med.
  doi: 10.17221/8880-VETMED
– volume: 70
  start-page: 700
  year: 2005
  ident: ref_42
  article-title: Curcumin (Diferuloylmethane) Inhibits Constitutive NF-ΚB Activation, Induces G1/S Arrest, Suppresses Proliferation, and Induces Apoptosis in Mantle Cell Lymphoma
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/j.bcp.2005.04.043
– volume: 147
  start-page: 629
  year: 2020
  ident: ref_59
  article-title: Curcumin-Loaded Polysaccharides-Based Complex Particles Obtained by Polyelectrolyte Complexation and Ionic Gelation. I-Particles Obtaining and Characterization
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2019.12.247
– volume: 134
  start-page: 44789
  year: 2017
  ident: ref_53
  article-title: Surface Modification and Antimicrobial Properties of Cellulose Nanocrystals
  publication-title: J. Appl. Polym. Sci.
  doi: 10.1002/app.44789
– volume: 63
  start-page: 9731
  year: 2022
  ident: ref_64
  article-title: An Updated and Comprehensive Review on the Potential Health Effects of Curcumin-Encapsulated Micro/Nanoparticles
  publication-title: Crit. Rev. Food Sci. Nutr.
  doi: 10.1080/10408398.2022.2070906
– volume: 138
  start-page: 1064
  year: 2019
  ident: ref_16
  article-title: Surface-Modified Nanocrystalline Cellulose from Oil Palm Empty Fruit Bunch for Effective Binding of Curcumin
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2019.07.035
– volume: 66
  start-page: 680
  year: 2015
  ident: ref_65
  article-title: Optimization of Caco-2 and HT29 Co-Culture in Vitro Cell Models for Permeability Studies
  publication-title: Int. J. Food Sci. Nutr.
  doi: 10.3109/09637486.2015.1077792
– volume: 121
  start-page: 277
  year: 2022
  ident: ref_69
  article-title: Spatial Configuration of Charge and Hydrophobicity Tune Particle Transport through Mucus
  publication-title: Biophys. J.
  doi: 10.1016/j.bpj.2021.12.018
– volume: 231
  start-page: 115745
  year: 2020
  ident: ref_13
  article-title: Co-Delivery of Doxorubicin and Curcumin by a PH-Sensitive, Injectable, and in Situ Hydrogel Composed of Chitosan, Graphene, and Cellulose Nanowhisker
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2019.115745
– volume: 19
  start-page: 20091
  year: 2014
  ident: ref_32
  article-title: The Chemistry of Curcumin: From Extraction to Therapeutic Agent
  publication-title: Molecules
  doi: 10.3390/molecules191220091
– volume: 8
  start-page: 31
  year: 2017
  ident: ref_45
  article-title: Ameliorating Amyloid-β Fibrils Triggered Inflammation via Curcumin-Loaded Polymeric Nanoconstructs
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2017.01411
– volume: 270
  start-page: 24995
  year: 1995
  ident: ref_44
  article-title: Activation of Transcription Factor NF-ΚB Is Suppressed by Curcumin (Diferuloylmethane)
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.270.42.24995
– volume: 10
  start-page: 6847
  year: 2004
  ident: ref_9
  article-title: Phase I Clinical Trial of Oral Curcumin: Biomarkers of Systemic Activity and Compliance
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-04-0744
– ident: ref_48
  doi: 10.1155/2014/186864
– volume: 44
  start-page: e14365
  year: 2020
  ident: ref_24
  article-title: Hygroscopic, Structural, and Thermal Properties of Essential Oil Microparticles of Sweet Orange Added with Cellulose Nanofibrils
  publication-title: J. Food Process. Preserv.
– volume: 59
  start-page: 3468
  year: 2019
  ident: ref_2
  article-title: Application of Different Nanocarriers for Encapsulation of Curcumin
  publication-title: Crit. Rev. Food Sci. Nutr.
  doi: 10.1080/10408398.2018.1495174
– volume: 14
  start-page: 111
  year: 2015
  ident: ref_31
  article-title: Hurdles and Pitfalls in Measuring Antioxidant Efficacy: A Critical Evaluation of ABTS, DPPH, and ORAC Assays
  publication-title: J. Funct. Foods
  doi: 10.1016/j.jff.2015.01.043
– volume: 14
  start-page: 991
  year: 2019
  ident: ref_57
  article-title: INFOGEST Static in Vitro Simulation of Gastrointestinal Food Digestion
  publication-title: Nat. Protoc.
  doi: 10.1038/s41596-018-0119-1
– volume: 101
  start-page: 1053
  year: 2003
  ident: ref_43
  article-title: Curcumin (Diferuloylmethane) down-Regulates the Constitutive Activation of Nuclear Factor–ΚB and IκBα Kinase in Human Multiple Myeloma Cells, Leading to Suppression of Proliferation and Induction of Apoptosis
  publication-title: Blood
  doi: 10.1182/blood-2002-05-1320
– volume: 32
  start-page: 246
  year: 2016
  ident: ref_50
  article-title: Antibacterial Effects of Curcumin: An in Vitro Minimum Inhibitory Concentration Study
  publication-title: Toxicol. Ind. Health
  doi: 10.1177/0748233713498458
– volume: 4
  start-page: 750
  year: 2015
  ident: ref_29
  article-title: Synthesis and Evaluation of the Anti-Oxidant Capacity of Curcumin Glucuronides, the Major Curcumin Metabolites
  publication-title: Antioxidants
  doi: 10.3390/antiox4040750
– volume: 533
  start-page: 285
  year: 2017
  ident: ref_60
  article-title: Cellulose Nanofibers as Excipient for the Delivery of Poorly Soluble Drugs
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2017.09.064
– ident: ref_49
  doi: 10.3390/antibiotics11030322
– ident: ref_12
  doi: 10.3390/nano11102593
– volume: 48
  start-page: 173
  year: 2001
  ident: ref_68
  article-title: Drug Transfer through Mucus
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/S0169-409X(01)00115-6
– volume: 6
  start-page: 20093
  year: 2014
  ident: ref_17
  article-title: Layer-by-Layer Assembled Thin Films and Microcapsules of Nanocrystalline Cellulose for Hydrophobic Drug Delivery
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/am505681e
– volume: 75
  start-page: 787
  year: 2008
  ident: ref_5
  article-title: Curcumin as “Curecumin”: From Kitchen to Clinic
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/j.bcp.2007.08.016
– volume: 25
  start-page: 1249
  year: 2018
  ident: ref_14
  article-title: Controlled Release of Carvacrol and Curcumin: Bio-Based Food Packaging by Synergism Action of TEMPO-Oxidized Cellulose Nanocrystals and Cyclodextrin
  publication-title: Cellulose
  doi: 10.1007/s10570-017-1646-6
SSID ssj0057141
Score 2.3409617
Snippet Curcumin is a natural phenolic compound with important biological functions. Despite its demonstrated efficacy in vitro, curcumin biological activities in vivo...
SourceID doaj
proquest
gale
pubmed
crossref
SourceType Open Website
Aggregation Database
Index Database
Enrichment Source
StartPage 1737
SubjectTerms Anti-inflammatory drugs
Antioxidants
Bioavailability
Biological activity
biological potential
Cellulose
Chemical properties
CNC-CTAB
curcumin
Cytotoxicity
delivery system
Dosage and administration
Free radicals
Health aspects
Inflammation
intestinal permeability
Metabolism
Nanocrystals
Nanomaterials
Particle size
Permeability
Structure
Surfactants
Testing
Turmeric
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9wwEBYlp1xK26TttklQaEkpxMSyLMk-pktCKKTsIYHcjF4Gg9cOu_bBf6C_uzOWdzdpC730ZqyRsTQPfYPH3xDyWVnJSwkaKD0XUaq0j4zIWGTKUjObO-9K_KJ7-0Pe3KffH8TDk1ZfWBMW6IHDxl2YEhzQJV7nMU8BzmbW5l4mSaaNQqoXjL5w5m2SqRCDhWIpC2SkHJL6C-wHwAB8Y7fzJ8fPyNL_Zyz-DWGOJ831K_Jygoj0Mrzaa_LCN2_I2SJwTA_n9G73y9T6nJ7RxY59ejggP0N3Sdx7umg7LAaCK904CgN6bI8YCmIH2pb0qrEa8uQaEKej835l-2XV0KrpWjr33VB3yP4PugS7AXut-iWFvH1ZOU9vW1eVFc7ydd3X7dpTiNStXQ2AN-v1Ibm_vrqb30RTs4XICsa7KC2ly2IrjELUoSW4ukkMfng1idYxcywxPnXKath-5blkTuQG0i3IV2RsMv6W7DVt498TGisFKnbagIGkwjHNGTwh9TLXFhJiPSNfNzoo7MREjg0x6gIyEtRXsdPXjHzayj4G_o2_Sn1DVW4lkDN7vAGWVEyWVPzLkmbkCxpCgZ4Nr2P19IMCLAo5sopLpXLkdU9A8uiZJHikfT68MaViigjrIsljzA1Tls_I6XYYZ2KVW-PbfpQRMF9lIPMumOB2SYCseJ5J_uF_LPUj2U8ArIWynCOy1616fwzgqjMnox_9Agj3Jdc
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1ba5xAFB7azUtfSu_dNi1TWlIKkTiOzuhTSZYNoZCwlATyJnMzCK6TrvqwfyC_O-eou9u0pW_inBHHc_E7zvE7hHyRRvBCgAYKx5MglsoFOklZoItCMZNZZwvc0T2_EGdX8Y_r5Hr84NaMZZWbmNgHausNfiM_irIQsXXMsu-3vwLsGoW7q2MLjcdkD0Jwmk7I3sn8YvFzE4sTyWI2kJJySO6PsC8AAxCOXc9_ew31bP1_x-Q_kGb_xjl9Rp6OUJEeD7p9Th65-gU5WAxc0-tDern7dao5pAd0sWOhXr8kd0OXSdQBXfgWi4LgSNWWwoDq2yQOhbFr6gs6r42CfLkC5GnprFuZblnWtKxbT2euXVctdgEAnYL9wIMouyWF_H1ZWkfPvS2LEme5quoq3zgKEdub1RpwZ9W8Ilen88vZWTA2XQhMwngbxIWwaWgSLRF9KAEuryONG7A6UipklkXaxVYalTkhHRfMJpmGtAvyFhHqlL8mk9rX7i2hoZSgaqs0GEqcWKY4gyvETmTKQGKspuTbRge5GRnJsTFGlUNmgvrKd_qaks9b2duBh-OfUieoyq0Ecmf3J_zqJh9dMdcFhHQbOZWFPIYEKTUGlhJFqdISyYOm5CsaQo4eDrdj1PijAiwKubLyYykz5HePQHL_gSR4pnk4vDGlfIwMTb6z4yn5tB3GmVjtVjvf9TIJzJcpyLwZTHC7JEBYPEsFf_f_i78nTyKAY0PhzT6ZtKvOfQD41OqPo4_cA-CuHk0
  priority: 102
  providerName: ProQuest
Title Biological Potential and Bioaccessibility of Encapsulated Curcumin into Cetyltrimethylammonium Bromide Modified Cellulose Nanocrystals
URI https://www.ncbi.nlm.nih.gov/pubmed/38139863
https://www.proquest.com/docview/2904875419
https://www.proquest.com/docview/2905526789
https://doaj.org/article/bfdded2ea90340498cc9e6228ab71716
Volume 16
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1da5xAFB3S5KUvpd_dNl2mtKQUYqPj6OhDKcmyIRQ2LCULeZP5sgiutq5C_QP93b1XXZdN89A3ce6I470zc48zcw4hH4QO_TQED6TWDxwupHVUEHmOSlPp6dhYk-KK7uI6vFrxb7fB7QHZ6ncOH3BzL7RDPalVlX_-_av9Ch3-CyJOgOxnyPbvQWrtiwfkCGYkgUoGCz6uJgSiV7DEQ11OxLjoaUrv1N2bmDr-_n9H6Tu5ZzcHXT4mj4bkkZ733n5CDmzxlJwse_bp9pTe7A5TbU7pCV3ueKnbZ-RPrzuJXqHLssZtQnAlC0OhQHbCif1W2ZaWKZ0XWgKCziEXNXTWVLpZZwXNirqkM1u3eY26AOBliCiI5KxZU0D068xYuihNlmZYy-Z5k5cbS2EML3XVQiaab56T1eX8ZnblDDIMjg48v3Z4GprI1YESmI_IEAYBxRQuySompesZjynLjdAytqGwfuiZIFYAxADJhK6K_BfksCgL-4pQVwhwvpEKQocHxpO-B0_gNoylBqgsJ-TT1geJHjjKUSojTwCroL-Snb8m5P1o-7Nn5rjX6gJdOVogm3Z3o6x-JEPnTFQKg7xhVsauzwEyRVpDUxiLpBJIJzQhHzEQEoxCeB0th6ML0Chkz0rOhYiR8Z2B5fGeJfRVvV-8DaVkG-oJi11EjdyLJ-TdWIw1cf9bYcumswmgvojA5mUfgmOTIOfy4yj0X__XB3lDHjLI0_odOcfksK4a-xbyqlpNydHF_Hr5fdr9l5h2XegvAn8k7A
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF6V9AAXxJtAgUVAEVKtev1a-4BQE1KltIkilEq9mX0ZWXLskthC_gP8HH4jM7aTUEDcerOysytv5tuZb7y7M4S85ipwkwA0kBjXtzwujCX9kFkySQRTkTY6wR3dyTQYn3ufLvyLHfJzfRcGj1WubWJjqHWh8Bv5oRPZyK09Fn24_GZh1SjcXV2X0GhhcWrq7xCyrd6ffAT9vnGc49F8OLa6qgKW8plbWl4S6NBWvuToXkUAmJaOxB1G6QhhM80caTzNlYhMwI0bMO1HEuIKIOaBLUMXxr1Bdj03sJ0e2R2MprPPa9vvc-axNgmq60b2IdYhYED6scr6b26vqQ7wtw_4g9k2Hu74DrndUVN61GLpLtkx-T2yP2tzW9cHdL69qrU6oPt0ts16Xd8nP9qqlqhzOitKPIQETyLXFBpEU5axPYhb0yKho1wJiM8zYLqaDqulqhZpTtO8LOjQlHVWYtUBwBDgFf74tFrQwbJYpNrQSaHTJMVeJsuqrFgZCh6iUMsaeG62ekDOr0UdD0kvL3LzmFCbc4CWFhKA6fmaCZfBCJ4JIqEgEBd98m6tg1h1GdCxEEcWQySE-oq3-uqTVxvZyzbvxz-lBqjKjQTm6m5-KJZf427pxzIBF6IdIyLb9SAgC5WCqThOKCTHZEV98haBEKNFgddRorsYAZPC3FzxEecR5pN3QHLviiRYAnW1eQ2luLNEq3i7bvrk5aYZe-LputwUVSPjQ38egsyjFoKbKQGjc6MwcJ_8f_AX5OZ4PjmLz06mp0_JLQeoYHvoZ4_0ymVlngF1K-Xzbr1Q8uW6l-gvD2JZpg
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3bbtNAEF2VVEK8IO4ECiwCipBqxevb2g8INWmjltIoQq3UN7M3I0uOXRJbyD_AR_F1zPiSUEC89S2KZ1fZzNm5eGfnEPKaq8BNAtBAYlzf8rgwlvRDZskkEUxF2ugET3RPZ8HRuffxwr_YIj_7uzBYVtnbxMZQ60LhO_KRE9kYW3ssGiVdWcT8YPrh8puFDFJ40trTabQQOTH1d0jfVu-PD0DXbxxneng2ObI6hgFL-cwtLS8JdGgrX3J0tSIAfEtH4mmjdISwmWaONJ7mSkQm4MYNmPYjCTkGBOmBLUMX5r1BtjlmRQOyPT6czT_3fsDnzGNtQ1TXjewRchIwSACQcf03F9gwBfztD_6IchtvN71DbndhKt1vcXWXbJn8Htmdt32u6z16trm2tdqju3S-6YBd3yc_WoZL1D-dFyUWJMEnkWsKD0RD0dgW5da0SOhhrgTk6hlEvZpOqqWqFmlO07ws6MSUdVYiAwHgCbALf3xaLeh4WSxSbehpodMkxVEmy6qsWBkK3qJQyxpi3mz1gJxfizoekkFe5OYxoTbnADMtJIDU8zUTLoMZPBNEQkFSLobkXa-DWHXd0JGUI4shK0J9xRt9Dcmrtexl2wPkn1JjVOVaAvt2N18Uy69xZwZimYA70Y4Rke16kJyFSsFSHCcUkmPjoiF5i0CI0brAz1GiuyQBi8I-XfE-5xH2lndAcueKJFgFdfVxD6W4s0qreLOHhuTl-jGOxEq73BRVI-PDeB6CzKMWguslQXTnRmHgPvn_5C_ITdia8afj2clTcsuBqLCt_9khg3JZmWcQxZXyebddKPly3Tv0Fwo6Xds
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Biological+Potential+and+Bioaccessibility+of+Encapsulated+Curcumin+into+Cetyltrimethylammonium+Bromide+Modified+Cellulose+Nanocrystals&rft.jtitle=Pharmaceuticals+%28Basel%2C+Switzerland%29&rft.au=Casanova%2C+Francisca&rft.au=Pereira%2C+Carla+F.&rft.au=Ribeiro%2C+Alessandra+B.&rft.au=Castro%2C+Pedro+M.&rft.date=2023-12-01&rft.issn=1424-8247&rft.eissn=1424-8247&rft.volume=16&rft.issue=12&rft.spage=1737&rft_id=info:doi/10.3390%2Fph16121737&rft.externalDBID=n%2Fa&rft.externalDocID=10_3390_ph16121737
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1424-8247&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1424-8247&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1424-8247&client=summon