The Combination of Intravenous Immunoglobulin, Dexamethasone, and a High Dose of Mononuclear Cells Transfusion: An Effective Strategy for Decreasing Donor-Specific Antibodies During Haploidentical Hematopoietic Stem Cell Transplantation

• Published in: Cell transplantation Vol. 34; p. 9636897241303292
• Main Authors: Li, Xiaoping, Li, Yu, Zhang, Dingsong, Hu, Xiaozhuang, Liu, Lin, Yuan, Zhongtao, Li, Shiqi, Dong, Yancheng, Chen, Yingnian, Wang, Sanbin
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.01.2025; Sage Publications Ltd; SAGE Publishing
• Subjects: Adolescent; Adult; Dexamethasone; Dexamethasone - pharmacology; Dexamethasone - therapeutic use; Engraftment; Female; Graft rejection; Graft vs Host Disease; Graft-versus-Host Disease and Graft-versus-Leukemia Effects after Hematopoietic Stem Cell Transplant; Graft-versus-host reaction; Hematopoietic Stem Cell Transplantation - methods; Hematopoietic stem cells; Humans; Immunoglobulins; Immunoglobulins, Intravenous - therapeutic use; Intravenous administration; Leukocytes (mononuclear); Leukocytes (neutrophilic); Leukocytes, Mononuclear - transplantation; Male; Middle Aged; Peripheral blood; Retrospective Studies; Stem cell transplantation; Tissue Donors; Transplantation, Haploidentical - methods; Young Adult; haploidentical hematopoietic stem cell transplantation; high dose of mononuclear cells transfusion; Donor-specific antibodies; primary graft failure

Donor-specific antibodies (DSAs) are essential causes of graft rejection in haploidentical hematopoietic stem cell transplantation (haplo-HSCT). DSAs are unavoidable for some patients who have no alternative donor. Effective interventions to reduce DSAs are still needed, and the cost of the current...