Initiation of pharmacological therapy in Parkinson's disease: when, why, and how

• Published in: Lancet neurology Vol. 19; no. 5; pp. 452 - 461
• Main Authors: de Bie, Rob M A, Clarke, Carl E, Espay, Alberto J, Fox, Susan H, Lang, Anthony E
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2020; Elsevier Limited
• Subjects: Amine oxidase (flavin-containing); Dopamine; Dopamine receptors; Drug dosages; Drug therapy; Dyskinesia; Levodopa; Medical treatment; Movement disorders; Neurodegenerative diseases; Parkinson's disease; Patients; Quality of life; Italy; Ghana

Debate is ongoing regarding when, why, and how to initiate pharmacotherapy for Parkinson's disease. Early initiation of dopaminergic therapies does not convey disease-modifying effects but does reduce disability. Concerns about the development of motor complications arising from the early initi...