Native and bioengineered extracellular vesicles for cardiovascular therapeutics

Extracellular vesicles (EVs) are a heterogeneous group of natural particles that are relevant to the treatment of cardiovascular diseases. These endogenous vesicles have certain properties that allow them to survive in the extracellular space, bypass biological barriers and deliver their biologicall...

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Published inNature reviews cardiology Vol. 17; no. 11; pp. 685 - 697
Main Authors de Abreu, Ricardo Cerqueira, Fernandes, Hugo, da Costa Martins, Paula A., Sahoo, Susmita, Emanueli, Costanza, Ferreira, Lino
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.11.2020
Nature Publishing Group
Subjects
631/61/54
692/4019/592/2725
692/699/75
692/700/565
Bioengineering
Biological activity
Brain - physiology
Cardiac Imaging
Cardiac Surgery
Cardiology
Cardiovascular diseases
Cardiovascular Diseases - therapy
Cardiovascular research
Care and treatment
Cell organelles
Cell Survival
Development and progression
Extracellular vesicles
Extracellular Vesicles - metabolism
Extracellular Vesicles - transplantation
Extremities - blood supply
Genetic aspects
Health aspects
Heart - physiology
Humans
Innovations
Ischemia - therapy
Medicine
Medicine & Public Health
MicroRNAs - metabolism
MicroRNAs - therapeutic use
Myocardial Infarction - therapy
Myocytes, Cardiac
Paracrine Communication
Regeneration
Review Article
Stem Cells - metabolism
Stroke - therapy
Tissue engineering
Netherlands
Online AccessGet full text

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Abstract Extracellular vesicles (EVs) are a heterogeneous group of natural particles that are relevant to the treatment of cardiovascular diseases. These endogenous vesicles have certain properties that allow them to survive in the extracellular space, bypass biological barriers and deliver their biologically active molecular cargo to recipient cells. Moreover, EVs can be bioengineered to increase their stability, bioactivity, presentation to acceptor cells and capacity for on-target binding at both cell-type-specific and tissue-specific levels. Bioengineering of EVs involves the modification of the donor cell before EV isolation or direct modification of the EV properties after isolation. The therapeutic potential of native EVs and bioengineered EVs has been only minimally explored in the context of cardiovascular diseases. Efforts to harness the therapeutic potential of EVs will require innovative approaches and a comprehensive integration of knowledge gathered from decades of research into molecular-compound delivery. In this Review, we outline the endogenous properties of EVs that make them natural delivery agents as well as the features that can be improved by bioengineering. We also discuss the therapeutic applications of native and bioengineered EVs to cardiovascular diseases and examine the opportunities and challenges that need to be addressed to advance this research area, with an emphasis on clinical translation. Extracellular vesicles are a heterogeneous group of natural particles that can deliver their biologically active molecular cargo to recipient cells. In this Review, the authors outline the endogenous properties of extracellular vesicles that make them natural delivery agents and the features that can be improved by bioengineering for the treatment of cardiovascular diseases. Key points Extracellular vesicles (EVs) secreted from stem or progenitor cells and from differentiated somatic cells have regenerative properties in the context of myocardial infarction, ischaemic limb disease and stroke. Despite the benefits of native EVs as delivery agents, their application in the cardiovascular context is hindered by intrinsic drawbacks, such as their undefined and heterogeneous nature and limited tropism. EVs can be improved by bioengineering approaches using both pre-isolation and post-isolation methods to increase the targeting, bioactivity, kinetics, biodistribution and contents of EVs. Bioengineering of EVs is necessary to improve their clinical potential for cardiovascular applications.
AbstractList Extracellular vesicles (EVs) are a heterogeneous group of natural particles that are relevant to the treatment of cardiovascular diseases. These endogenous vesicles have certain properties that allow them to survive in the extracellular space, bypass biological barriers and deliver their biologically active molecular cargo to recipient cells. Moreover, EVs can be bioengineered to increase their stability, bioactivity, presentation to acceptor cells and capacity for on-target binding at both cell-type-specific and tissue-specific levels. Bioengineering of EVs involves the modification of the donor cell before EV isolation or direct modification of the EV properties after isolation. The therapeutic potential of native EVs and bioengineered EVs has been only minimally explored in the context of cardiovascular diseases. Efforts to harness the therapeutic potential of EVs will require innovative approaches and a comprehensive integration of knowledge gathered from decades of research into molecular-compound delivery. In this Review, we outline the endogenous properties of EVs that make them natural delivery agents as well as the features that can be improved by bioengineering. We also discuss the therapeutic applications of native and bioengineered EVs to cardiovascular diseases and examine the opportunities and challenges that need to be addressed to advance this research area, with an emphasis on clinical translation. Extracellular vesicles are a heterogeneous group of natural particles that can deliver their biologically active molecular cargo to recipient cells. In this Review, the authors outline the endogenous properties of extracellular vesicles that make them natural delivery agents and the features that can be improved by bioengineering for the treatment of cardiovascular diseases. Key points Extracellular vesicles (EVs) secreted from stem or progenitor cells and from differentiated somatic cells have regenerative properties in the context of myocardial infarction, ischaemic limb disease and stroke. Despite the benefits of native EVs as delivery agents, their application in the cardiovascular context is hindered by intrinsic drawbacks, such as their undefined and heterogeneous nature and limited tropism. EVs can be improved by bioengineering approaches using both pre-isolation and post-isolation methods to increase the targeting, bioactivity, kinetics, biodistribution and contents of EVs. Bioengineering of EVs is necessary to improve their clinical potential for cardiovascular applications.
Extracellular vesicles (EVs) are a heterogeneous group of natural particles that are relevant to the treatment of cardiovascular diseases. These endogenous vesicles have certain properties that allow them to survive in the extracellular space, bypass biological barriers and deliver their biologically active molecular cargo to recipient cells. Moreover, EVs can be bioengineered to increase their stability, bioactivity, presentation to acceptor cells and capacity for on-target binding at both cell-type-specific and tissue-specific levels. Bioengineering of EVs involves the modification of the donor cell before EV isolation or direct modification of the EV properties after isolation. The therapeutic potential of native EVs and bioengineered EVs has been only minimally explored in the context of cardiovascular diseases. Efforts to harness the therapeutic potential of EVs will require innovative approaches and a comprehensive integration of knowledge gathered from decades of research into molecular-compound delivery. In this Review, we outline the endogenous properties of EVs that make them natural delivery agents as well as the features that can be improved by bioengineering. We also discuss the therapeutic applications of native and bioengineered EVs to cardiovascular diseases and examine the opportunities and challenges that need to be addressed to advance this research area, with an emphasis on clinical translation.
Extracellular vesicles (EVs) are a heterogeneous group of natural particles that are relevant to the treatment of cardiovascular diseases. These endogenous vesicles have certain properties that allow them to survive in the extracellular space, bypass biological barriers and deliver their biologically active molecular cargo to recipient cells. Moreover, EVs can be bioengineered to increase their stability, bioactivity, presentation to acceptor cells and capacity for on-target binding at both cell-type-specific and tissue-specific levels. Bioengineering of EVs involves the modification of the donor cell before EV isolation or direct modification of the EV properties after isolation. The therapeutic potential of native EVs and bioengineered EVs has been only minimally explored in the context of cardiovascular diseases. Efforts to harness the therapeutic potential of EVs will require innovative approaches and a comprehensive integration of knowledge gathered from decades of research into molecular-compound delivery. In this Review, we outline the endogenous properties of EVs that make them natural delivery agents as well as the features that can be improved by bioengineering. We also discuss the therapeutic applications of native and bioengineered EVs to cardiovascular diseases and examine the opportunities and challenges that need to be addressed to advance this research area, with an emphasis on clinical translation.
Extracellular vesicles (EVs) are a heterogeneous group of natural particles that are relevant to the treatment of cardiovascular diseases. These endogenous vesicles have certain properties that allow them to survive in the extracellular space, bypass biological barriers and deliver their biologically active molecular cargo to recipient cells. Moreover, EVs can be bioengineered to increase their stability, bioactivity, presentation to acceptor cells and capacity for on-target binding at both cell-type-specific and tissue-specific levels. Bioengineering of EVs involves the modification of the donor cell before EV isolation or direct modification of the EV properties after isolation. The therapeutic potential of native EVs and bioengineered EVs has been only minimally explored in the context of cardiovascular diseases. Efforts to harness the therapeutic potential of EVs will require innovative approaches and a comprehensive integration of knowledge gathered from decades of research into molecular-compound delivery. In this Review, we outline the endogenous properties of EVs that make them natural delivery agents as well as the features that can be improved by bioengineering. We also discuss the therapeutic applications of native and bioengineered EVs to cardiovascular diseases and examine the opportunities and challenges that need to be addressed to advance this research area, with an emphasis on clinical translation. Extracellular vesicles are a heterogeneous group of natural particles that can deliver their biologically active molecular cargo to recipient cells. In this Review, the authors outline the endogenous properties of extracellular vesicles that make them natural delivery agents and the features that can be improved by bioengineering for the treatment of cardiovascular diseases. Key points Extracellular vesicles (EVs) secreted from stem or progenitor cells and from differentiated somatic cells have regenerative properties in the context of myocardial infarction, ischaemic limb disease and stroke. Despite the benefits of native EVs as delivery agents, their application in the cardiovascular context is hindered by intrinsic drawbacks, such as their undefined and heterogeneous nature and limited tropism. EVs can be improved by bioengineering approaches using both pre-isolation and post-isolation methods to increase the targeting, bioactivity, kinetics, biodistribution and contents of EVs. Bioengineering of EVs is necessary to improve their clinical potential for cardiovascular applications.
Extracellular vesicles (EVs) are a heterogeneous group of natural particles that are relevant to the treatment of cardiovascular diseases. These endogenous vesicles have certain properties that allow them to survive in the extracellular space, bypass biological barriers and deliver their biologically active molecular cargo to recipient cells. Moreover, EVs can be bioengineered to increase their stability, bioactivity, presentation to acceptor cells and capacity for on-target binding at both cell-type-specific and tissue-specific levels. Bioengineering of EVs involves the modification of the donor cell before EV isolation or direct modification of the EV properties after isolation. The therapeutic potential of native EVs and bioengineered EVs has been only minimally explored in the context of cardiovascular diseases. Efforts to harness the therapeutic potential of EVs will require innovative approaches and a comprehensive integration of knowledge gathered from decades of research into molecular-compound delivery. In this Review, we outline the endogenous properties of EVs that make them natural delivery agents as well as the features that can be improved by bioengineering. We also discuss the therapeutic applications of native and bioengineered EVs to cardiovascular diseases and examine the opportunities and challenges that need to be addressed to advance this research area, with an emphasis on clinical translation.Extracellular vesicles are a heterogeneous group of natural particles that can deliver their biologically active molecular cargo to recipient cells. In this Review, the authors outline the endogenous properties of extracellular vesicles that make them natural delivery agents and the features that can be improved by bioengineering for the treatment of cardiovascular diseases.
Audience Academic
Author Emanueli, Costanza
Sahoo, Susmita
de Abreu, Ricardo Cerqueira
Fernandes, Hugo
da Costa Martins, Paula A.
Ferreira, Lino
Author_xml – sequence: 1
  givenname: Ricardo Cerqueira
  surname: de Abreu
  fullname: de Abreu, Ricardo Cerqueira
  organization: CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, Department of Molecular Genetics, Faculty of Sciences and Engineering, Maastricht University, CNC-Centre for Neuroscience and Cell Biology, University of Coimbra
– sequence: 2
  givenname: Hugo
  surname: Fernandes
  fullname: Fernandes, Hugo
  organization: Faculty of Medicine, University of Coimbra
– sequence: 3
  givenname: Paula A.
  orcidid: 0000-0002-0695-1187
  surname: da Costa Martins
  fullname: da Costa Martins, Paula A.
  organization: CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, Department of Molecular Genetics, Faculty of Sciences and Engineering, Maastricht University
– sequence: 4
  givenname: Susmita
  surname: Sahoo
  fullname: Sahoo, Susmita
  organization: Division of Cardiology, Department of Medicine, Icahn School of Medicine at Mount Sinai
– sequence: 5
  givenname: Costanza
  surname: Emanueli
  fullname: Emanueli, Costanza
  organization: National Heart & Lung Institute, Imperial College London
– sequence: 6
  givenname: Lino
  surname: Ferreira
  fullname: Ferreira, Lino
  email: lino@uc-biotech.pt
  organization: CNC-Centre for Neuroscience and Cell Biology, University of Coimbra, Faculty of Medicine, University of Coimbra
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32483304$$D View this record in MEDLINE/PubMed
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crossref_primary_10_1186_s12951_023_02129_1
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Snippet Extracellular vesicles (EVs) are a heterogeneous group of natural particles that are relevant to the treatment of cardiovascular diseases. These endogenous...
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SubjectTerms 631/61/54
692/4019/592/2725
692/699/75
692/700/565
Bioengineering
Biological activity
Brain - physiology
Cardiac Imaging
Cardiac Surgery
Cardiology
Cardiovascular diseases
Cardiovascular Diseases - therapy
Cardiovascular research
Care and treatment
Cell organelles
Cell Survival
Development and progression
Extracellular vesicles
Extracellular Vesicles - metabolism
Extracellular Vesicles - transplantation
Extremities - blood supply
Genetic aspects
Health aspects
Heart - physiology
Humans
Innovations
Ischemia - therapy
Medicine
Medicine & Public Health
MicroRNAs - metabolism
MicroRNAs - therapeutic use
Myocardial Infarction - therapy
Myocytes, Cardiac
Paracrine Communication
Regeneration
Review Article
Stem Cells - metabolism
Stroke - therapy
Tissue engineering
Title Native and bioengineered extracellular vesicles for cardiovascular therapeutics
URI https://link.springer.com/article/10.1038/s41569-020-0389-5
https://www.ncbi.nlm.nih.gov/pubmed/32483304
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Volume 17
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