Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia

• Published in: Molecular psychiatry Vol. 23; no. 5; pp. 1270 - 1277
• Main Authors: Teng, S, Thomson, P A, McCarthy, S, Kramer, M, Muller, S, Lihm, J, Morris, S, Soares, D C, Hennah, W, Harris, S, Camargo, L M, Malkov, V, McIntosh, A M, Millar, J K, Blackwood, D H, Evans, K L, Deary, I J, Porteous, D J, McCombie, W R
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2018; Nature Publishing Group
• Subjects: 631/208; 692/699/476; 692/699/476/1333; 692/699/476/1414; 692/699/476/1799; Adult; Aged; Behavioral Sciences; Biological Psychology; Bipolar disorder; Bipolar Disorder - genetics; Brain - metabolism; Case-Control Studies; Cognition; Cognitive ability; Cognitive Dysfunction - genetics; Copy number; Depression; Depressive Disorder, Major - genetics; Disc1 protein; Female; Gene regulation; Genetic aspects; Genetic Predisposition to Disease; Genetic variation; Health aspects; Humans; Interactomes; Male; Medicine; Medicine & Public Health; Mental depression; Mental disorders; Middle Aged; Molecular biology; Nerve Tissue Proteins - genetics; Neurobiology; Neurodevelopmental disorders; Neurosciences; Neurosis; Original; original-article; Pharmacotherapy; Pleiotropy; Polymorphism, Single Nucleotide; Protein Interaction Maps; Psychiatric research; Psychiatry; Psychological aspects; Schizophrenia; Schizophrenia - genetics

Schizophrenia (SCZ), bipolar disorder (BD) and recurrent major depressive disorder (rMDD) are common psychiatric illnesses. All have been associated with lower cognitive ability, and show evidence of genetic overlap and substantial evidence of pleiotropy with cognitive function and neuroticism. Disr...