Brain volumes as predictor of outcome in recent-onset schizophrenia: a multi-center MRI study

• Published in: Schizophrenia research Vol. 64; no. 1; pp. 41 - 52
• Main Authors: van Haren, Neeltje E.M., Cahn, Wiepke, Hulshoff Pol, Hilleke E., Schnack, Hugo G., Caspers, Esther, Lemstra, Adriaan, Sitskoorn, Margriet M., Wiersma, Durk, van den Bosch, Rob J., Dingemans, Peter M., Schene, Aart H., Kahn, René S.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.11.2003; Elsevier Science
• Subjects: Adolescent; Adult; Adult and adolescent clinical studies; Biological and medical sciences; Brain - pathology; Brain Mapping; Calibration; Cerebellum - pathology; Cerebral Cortex - pathology; Cerebral Ventricles - pathology; Dominance, Cerebral - physiology; Female; Gray matter; Humans; Image Interpretation, Computer-Assisted; Longitudinal Studies; Magnetic Resonance Imaging; Male; Mathematical Computing; Medical sciences; Morphology; Multi-center; Netherlands; Neuropsychological Tests - statistics & numerical data; Phantoms, Imaging; Psychology. Psychoanalysis. Psychiatry; Psychometrics; Psychopathology. Psychiatry; Psychoses; Recent-onset; Reference Values; Reproducibility of Results; Schizophrenia; Schizophrenia - diagnosis; Schizophrenia - pathology; Schizophrenic Psychology; Netherlands; Multi-center; Schizophrenia; Calibration; Gray matter; Morphology; Recent-onset; Cerebellum; Volumetric analysis; Multicenter study; Central nervous system; Social adjustment; Encephalon; Psychosis; Third cerebral ventricle; Lateral cerebral ventricle; Human; Intracranial; Grey matter; Nuclear magnetic resonance imaging; Long term; White matter; Symptomatology; First episode; Follow up study; Medical imagery; Severity score; Predictive factor; Comparative study

Gray matter brain volume decreases have been found in patients with schizophrenia as compared to healthy control subjects measured by using Magnetic Resonance Imaging (MRI). An association has been suggested between decreased gray matter volume and poor outcome in chronically ill patients with schiz...