An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity

• Published in: Cancer research (Chicago, Ill.) Vol. 73; no. 9; pp. 2850 - 2862
• Main Authors: Williams, Kevin J., Argus, Joseph P., Zhu, Yue, Wilks, Moses Q., Marbois, Beth N., York, Autumn G., Kidani, Yoko, Pourzia, Alexandra L., Akhavan, David, Lisiero, Dominique N., Komisopoulou, Evangelia, Henkin, Amy H., Soto, Horacio, Chamberlain, Brian T., Vergnes, Laurent, Jung, Michael E., Torres, Jorge Z., Liau, Linda M., Christofk, Heather R., Prins, Robert M., Mischel, Paul S., Reue, Karen, Graeber, Thomas G., Bensinger, Steven J.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.05.2013
• Subjects: Animals; Antineoplastic agents; Biological and medical sciences; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Fatty Acid Synthases - metabolism; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins - metabolism; Medical sciences; Membrane Proteins - metabolism; Mice; Mice, Inbred NOD; Models, Statistical; Neoplasm Transplantation; Neoplasms - metabolism; Pharmacology. Drug treatments; Signal Transduction; Stearoyl-CoA Desaturase - metabolism; Sterols - metabolism; Tumors; Prevention; Signal transduction; Essential; Tumor cell

The sterol regulatory element-binding proteins (SREBP) are key transcriptional regulators of lipid metabolism and cellular growth. It has been proposed that SREBP signaling regulates cellular growth through its ability to drive lipid biosynthesis. Unexpectedly, we find that loss of SREBP activity in...