Obesity, colorectal cancer and MACC1 expression: A possible novel molecular association

• Published in: International journal of oncology Vol. 60; no. 2; p. 1
• Main Authors: Bähr, Ina, Jaeschke, Lina, Nimptsch, Katharina, Janke, Jürgen, Herrmann, Pia, Kobelt, Dennis, Kielstein, Heike, Pischon, Tobias, Stein, Ulrike
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.02.2022; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Adiposity - genetics; Adult; Aged; Analysis; Animals; Blood pressure; Body fat; Body Mass Index; Cancer; Cardiovascular disease; Cell Movement - genetics; Chronic illnesses; Colorectal cancer; Colorectal Neoplasms - epidemiology; Colorectal Neoplasms - genetics; Development and progression; Diabetes; Ethylenediaminetetraacetic acid; Exercise; Female; Females; Fitness training programs; Gene Expression - genetics; Genetic aspects; Glucose; Health aspects; Humans; Instrument industry; Laboratory animals; Male; Males; Metabolic syndrome; Metastasis; Middle Aged; Mortality; Nutrition research; Obesity; Obesity - epidemiology; Obesity - genetics; Oncology, Experimental; Overweight; Plasma; Public health; Rats; Rats, Wistar; Trans-Activators - genetics; Trans-Activators - metabolism; Type 2 diabetes; United States; Germany; human subjects; colorectal cancer; animals; plasma; MACC1 expression; obesity

Obesity is a major and increasing public health concern, associated with an increased risk of and mortality from several types of cancer including colorectal cancer (CRC), being associated with cancer progression, metastasis and resistance to therapy. It was hypothesized that the expression of cance...