Synthesis, Structure and Biological Activity of 2-Methyl-5-nitro-6-phenylnicotinohydrazide-Based Hydrazones

• Published in: Molecules (Basel, Switzerland) Vol. 30; no. 1; p. 169
• Main Authors: Nurkenov, Oralgazy A., Mendibayeva, Anel Z., Fazylov, Serik D., Seilkhanov, Tulegen M., Kabieva, Saule K., Syzdykov, Ardak K., Kulakov, Ilya I., Iashnikov, Aleksandr V., Vasilchenko, Alexey S., Alkhimova, Larisa E., Kulakov, Ivan V.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.01.2025; MDPI
• Subjects: Acids; Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antifungal agents; Antifungal Agents - chemical synthesis; Antifungal Agents - chemistry; Antifungal Agents - pharmacology; conformational analysis; Density Functional Theory; DFT calculations; Fungi - drug effects; hydrazides; Hydrazines - chemical synthesis; Hydrazines - chemistry; hydrazones; Hydrazones - chemical synthesis; Hydrazones - chemistry; Hydrazones - pharmacology; Hydrogen bonds; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; nicotinic acid; NMR spectroscopy; Nuclear magnetic resonance spectroscopy; Protons; Spectrum analysis; Structure-Activity Relationship; antibacterial activity; hydrazides; conformational analysis; NMR spectroscopy; DFT calculations; hydrazones; nicotinic acid

The synthetic availability and wide range of biological activity of hydrazides and hydrazones make them attractive subjects for investigation. In this study, we focused on synthesis of 2-methyl-5-nitro-6-phenylnicotinohydrazide-based hydrazones derived from the corresponding substituted aldehydes. T...