Down-regulation of intestinal epithelial innate response by probiotic yeasts isolated from kefir
Kefir is obtained by milk fermentation with a complex microbial population included in a matrix of polysaccharide and proteins. Several health-promoting activities has been attributed to kefir consumption. The aim of this study was to select microorganisms from kefir able to down-regulate intestinal...
Saved in:
Published in | International journal of food microbiology Vol. 140; no. 2; pp. 102 - 108 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Amsterdam
Elsevier B.V
15.06.2010
[Amsterdam; New York, NY]: Elsevier Science Elsevier |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Kefir is obtained by milk fermentation with a complex microbial population included in a matrix of polysaccharide and proteins. Several health-promoting activities has been attributed to kefir consumption. The aim of this study was to select microorganisms from kefir able to down-regulate intestinal epithelial innate response and further characterize this activity.
Caco-2 cells stably transfected with a human CCL20 promoter luciferase reporter were used to screen a collection of 24 yeast and 23 bacterial strains isolated from kefir. The Toll-like receptor 5 agonist, flagellin was used to activate the reporter cells, while pre-incubation with the selected strains was tested to identify strains with the capacity to inhibit cell activation. In this system, 21 yeast strains from the genera
Saccharomyces,
Kluyveromyces and
Issatchenkia inhibited almost 100% of the flagellin-dependent activation, whereas only some lactobacilli strains showed a partial effect.
K. marxianus CIDCA 8154 was selected for further characterization. Inhibitory activity was confirmed at transcriptional level on Caco-2/TC-7 and HT-29 cells upon flagellin stimulation. A similar effect was observed using other pro-inflammatory stimulation such as IL-1β and TNF-α. Pre-incubation with yeasts induced a down-regulation of NF-κB signalling in epithelial cells in vitro, as well as expression of other pro-inflammatory chemokines such as CXCL8 and CXCL2. Furthermore, modulation of CCL20 mRNA expression upon flagellin stimulation was evidenced
in vivo, in a mouse ligated intestinal loop model.
Results indicate kefir contains microorganisms able to abolish the intestinal epithelial inflammatory response that could explain some of the properties attributed to this fermented milk. |
---|---|
AbstractList | Kefir is obtained by milk fermentation with a complex microbial population included in a matrix of polysaccharide and proteins. Several health-promoting activities has been attributed to kefir consumption. The aim of this study was to select microorganisms from kefir able to down-regulate intestinal epithelial innate response and further characterize this activity.
Caco-2 cells stably transfected with a human CCL20 promoter luciferase reporter were used to screen a collection of 24 yeast and 23 bacterial strains isolated from kefir. The Toll-like receptor 5 agonist, flagellin was used to activate the reporter cells, while pre-incubation with the selected strains was tested to identify strains with the capacity to inhibit cell activation. In this system, 21 yeast strains from the genera
Saccharomyces,
Kluyveromyces and
Issatchenkia inhibited almost 100% of the flagellin-dependent activation, whereas only some lactobacilli strains showed a partial effect.
K. marxianus CIDCA 8154 was selected for further characterization. Inhibitory activity was confirmed at transcriptional level on Caco-2/TC-7 and HT-29 cells upon flagellin stimulation. A similar effect was observed using other pro-inflammatory stimulation such as IL-1β and TNF-α. Pre-incubation with yeasts induced a down-regulation of NF-κB signalling in epithelial cells in vitro, as well as expression of other pro-inflammatory chemokines such as CXCL8 and CXCL2. Furthermore, modulation of CCL20 mRNA expression upon flagellin stimulation was evidenced
in vivo, in a mouse ligated intestinal loop model.
Results indicate kefir contains microorganisms able to abolish the intestinal epithelial inflammatory response that could explain some of the properties attributed to this fermented milk. Kefir is obtained by milk fermentation with a complex microbial population included in a matrix of polysaccharide and proteins. Several health-promoting activities has been attributed to kefir consumption. The aim of this study was to select microorganisms from kefir able to down-regulate intestinal epithelial innate response and further characterize this activity. Caco-2 cells stably transfected with a human CCL20 promoter luciferase reporter were used to screen a collection of 24 yeast and 23 bacterial strains isolated from kefir. The Toll-like receptor 5 agonist, flagellin was used to activate the reporter cells, while pre-incubation with the selected strains was tested to identify strains with the capacity to inhibit cell activation. In this system, 21 yeast strains from the genera Saccharomyces, Kluyveromyces and Issatchenkia inhibited almost 100% of the flagellin-dependent activation, whereas only some lactobacilli strains showed a partial effect. K. marxianus CIDCA 8154 was selected for further characterization. Inhibitory activity was confirmed at transcriptional level on Caco-2/TC-7 and HT-29 cells upon flagellin stimulation. A similar effect was observed using other pro-inflammatory stimulation such as IL-1β and TNF-α. Pre-incubation with yeasts induced a down-regulation of NF-κB signalling in epithelial cells in vitro, as well as expression of other pro-inflammatory chemokines such as CXCL8 and CXCL2. Furthermore, modulation of CCL20 mRNA expression upon flagellin stimulation was evidenced in vivo, in a mouse ligated intestinal loop model. Results indicate kefir contains microorganisms able to abolish the intestinal epithelial inflammatory response that could explain some of the properties attributed to this fermented milk. Kefir is obtained by milk fermentation with a complex microbial population included in a matrix of polysaccharide and proteins. Several health-promoting activities has been attributed to kefir consumption. The aim of this study was to select microorganisms from kefir able to down-regulate intestinal epithelial innate response and further characterize this activity. Caco-2 cells stably transfected with a human CCL20 promoter luciferase reporter were used to screen a collection of 24 yeast and 23 bacterial strains isolated from kefir. The Toll-like receptor 5 agonist, flagellin was used to activate the reporter cells, while pre-incubation with the selected strains was tested to identify strains with the capacity to inhibit cell activation. In this system, 21 yeast strains from the genera Saccharomyces, Kluyveromyces and Issatchenkia inhibited almost 100% of the flagellin-dependent activation, whereas only some lactobacilli strains showed a partial effect. K. marxianus CIDCA 8154 was selected for further characterization. Inhibitory activity was confirmed at transcriptional level on Caco-2/TC-7 and HT-29 cells upon flagellin stimulation. A similar effect was observed using other pro-inflammatory stimulation such as IL-1beta and TNF-alpha. Pre-incubation with yeasts induced a down-regulation of NF-kappaB signalling in epithelial cells in vitro, as well as expression of other pro-inflammatory chemokines such as CXCL8 and CXCL2. Furthermore, modulation of CCL20 mRNA expression upon flagellin stimulation was evidenced in vivo, in a mouse ligated intestinal loop model. Results indicate kefir contains microorganisms able to abolish the intestinal epithelial inflammatory response that could explain some of the properties attributed to this fermented milk. Kefir is obtained by milk fermentation with a complex microbial population included in a matrix of polysaccharide and proteins. Several health-promoting activities has been attributed to kefir consumption. The aim of this study was to select microorganisms from kefir able to down-regulate intestinal epithelial innate response and further characterize this activity. Caco-2 cells stably transfected with a human CCL20 promoter luciferase reporter were used to screen a collection of 24 yeast and 23 bacterial strains isolated from kefir. The Toll-like receptor 5 agonist, flagellin was used to activate the reporter cells, while pre-incubation with the selected strains was tested to identify strains with the capacity to inhibit cell activation. In this system, 21 yeast strains from the genera Saccharomyces, Kluyveromyces and Issatchenkia inhibited almost 100% of the flagellin-dependent activation, whereas only some lactobacilli strains showed a partial effect. K. marxianus CIDCA 8154 was selected for further characterization. Inhibitory activity was confirmed at transcriptional level on Caco-2/TC-7 and HT-29 cells upon flagellin stimulation. A similar effect was observed using other pro-inflammatory stimulation such as IL-1b and TNF-a. Pre-incubation with yeasts induced a down-regulation of NF- Kappa B signalling in epithelial cells in vitro, as well as expression of other pro-inflammatory chemokines such as CXCL8 and CXCL2. Furthermore, modulation of CCL20 mRNA expression upon flagellin stimulation was evidenced in vivo, in a mouse ligated intestinal loop model. Results indicate kefir contains microorganisms able to abolish the intestinal epithelial inflammatory response that could explain some of the properties attributed to this fermented milk. |
Author | Serradell, María Lausada, Natalia Rumbo, Martín Romanin, David González Maciel, Dolores Garrote, Graciela L. |
Author_xml | – sequence: 1 givenname: David surname: Romanin fullname: Romanin, David email: dromanin@biol.unlp.edu.ar organization: Laboratorio de Investigaciones en el Sistema Inmune (LISIN), FCE, UNLP, 47 y 115, La Plata, Argentina – sequence: 2 givenname: María surname: Serradell fullname: Serradell, María email: maserr@biol.unlp.edu.ar organization: Cátedra de Microbiología, FCE, UNLP. 47 y 115, La Plata, Argentina – sequence: 3 givenname: Dolores surname: González Maciel fullname: González Maciel, Dolores email: dolores@biol.unlp.edu.ar organization: Laboratorio de Investigaciones en el Sistema Inmune (LISIN), FCE, UNLP, 47 y 115, La Plata, Argentina – sequence: 4 givenname: Natalia surname: Lausada fullname: Lausada, Natalia email: nlausada@atlas.med.unlp.edu.ar organization: Laboratorio-Programa de Transplante de Organos y Tejidos, FCM, UNLP, 60 y 120, La Plata, Argentina – sequence: 5 givenname: Graciela L. surname: Garrote fullname: Garrote, Graciela L. email: ggarrote@biol.unlp.edu.ar organization: Cátedra de Microbiología, FCE, UNLP. 47 y 115, La Plata, Argentina – sequence: 6 givenname: Martín surname: Rumbo fullname: Rumbo, Martín email: martinr@biol.unlp.edu.ar organization: Laboratorio de Investigaciones en el Sistema Inmune (LISIN), FCE, UNLP, 47 y 115, La Plata, Argentina |
BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22896562$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/20471126$$D View this record in MEDLINE/PubMed |
BookMark | eNqNkcuOEzEQRS00iMkEfgHMAs2qQ7n9aPcSBQaQRmIBszZud3lw6NjB7oDy9zhKeOxgVaXSqaqre6_IRUwRCXnOYMWAqZebVdj4lMZtcDmtWqhzECtg4gFZMN31DRcKLsiisrphCuQluSplAwCSc3hELlsQHWOtWpDPr9OP2GS83092DinS5GmIM5Y5RDtR3IX5C06htiFGOyPNWHYpFqTDge5yGkKag6MHtGUuNJRUz-BIfU5b-hV9yI_JQ2-ngk_OdUnubt58Wr9rbj-8fb9-dds4yfjccMmhU3wE7DsnPVeq5aqzXd921ltp9TAqzQR3YpQAwrd60K73nGmGMFjHl-T6dLeK-rav-s02FIfTZCOmfTGdkD1XWnT_JjlnrRTySPYnstpcSkZvdjlsbT4YBuaYhNmYv5IwxyQMCFOTqLtPz1_2wxbH35u_rK_AizNgi7OTzza6UP5wre6VrC4sybMT520y9j5X5u5j_cSBaVk18EqsTwRWf78HzKa4gNHhGDK62Ywp_Ifgn-UUuI0 |
CODEN | IJFMDD |
CitedBy_id | crossref_primary_10_1111_jam_13226 crossref_primary_10_1371_journal_pone_0078447 crossref_primary_10_1155_2019_1218058 crossref_primary_10_1371_journal_pone_0096595 crossref_primary_10_1590_1678_457x_13617 crossref_primary_10_1007_s00253_015_6776_x crossref_primary_10_1016_j_jff_2014_11_021 crossref_primary_10_1111_1471_0307_12161 crossref_primary_10_1093_femsyr_foad041 crossref_primary_10_1016_j_fshw_2019_08_003 crossref_primary_10_3389_fnut_2020_00027 crossref_primary_10_3168_jds_2021_21382 crossref_primary_10_1016_j_niox_2013_12_012 crossref_primary_10_1016_j_jff_2019_05_039 crossref_primary_10_3389_fmicb_2016_00647 crossref_primary_10_1017_S0022029912000179 crossref_primary_10_1371_journal_pone_0180884 crossref_primary_10_3920_BM2015_0191 crossref_primary_10_1111_jam_14107 crossref_primary_10_1590_1678_457x_10617 crossref_primary_10_1016_j_fbio_2023_102473 crossref_primary_10_1016_j_lwt_2019_108844 crossref_primary_10_1002_pro_3151 crossref_primary_10_1017_S0007114512004011 crossref_primary_10_1002_jsfa_6669 crossref_primary_10_1007_s11356_020_09833_7 crossref_primary_10_1016_j_tifs_2022_08_018 crossref_primary_10_7759_cureus_27768 crossref_primary_10_1016_j_foodres_2014_03_003 crossref_primary_10_1016_j_foodres_2019_108852 crossref_primary_10_1016_j_tifs_2021_07_038 crossref_primary_10_1590_1806_9061_2016_0220 crossref_primary_10_1007_s12602_014_9168_0 crossref_primary_10_1016_j_lwt_2019_02_023 crossref_primary_10_1016_j_idairyj_2020_104839 crossref_primary_10_1017_S0022029911000653 crossref_primary_10_1155_2015_361604 crossref_primary_10_1111_jam_13124 crossref_primary_10_1038_s41598_019_47872_4 crossref_primary_10_3390_antiox13020202 crossref_primary_10_1016_j_lwt_2017_11_047 crossref_primary_10_1016_j_foodres_2011_03_047 crossref_primary_10_1016_j_ijfoodmicro_2014_12_011 crossref_primary_10_1016_j_lwt_2016_08_020 crossref_primary_10_1111_lam_12481 crossref_primary_10_1002_yea_1723 crossref_primary_10_1099_mic_0_000709 crossref_primary_10_1017_S0022029910000610 crossref_primary_10_1128_AEM_06385_11 crossref_primary_10_3109_09637486_2013_816935 crossref_primary_10_1016_j_fm_2017_08_012 crossref_primary_10_1002_jsfa_10690 crossref_primary_10_1016_j_idairyj_2014_06_009 crossref_primary_10_1016_j_jff_2017_06_012 crossref_primary_10_1007_s11274_013_1419_9 crossref_primary_10_1016_j_heliyon_2022_e10850 crossref_primary_10_1016_j_idairyj_2013_06_004 crossref_primary_10_1016_j_ijfoodmicro_2012_08_016 crossref_primary_10_3390_foods11193148 crossref_primary_10_1016_j_jff_2019_04_046 crossref_primary_10_1590_S1516_89132014005000005 crossref_primary_10_1016_j_dld_2014_11_007 crossref_primary_10_3109_09637486_2015_1095861 crossref_primary_10_1093_mmy_myx156 crossref_primary_10_3168_jds_2015_10084 crossref_primary_10_3920_BM2015_0066 crossref_primary_10_1016_j_ijfoodmicro_2011_11_009 crossref_primary_10_1021_acs_jafc_4c02963 crossref_primary_10_1017_S0022029912000623 crossref_primary_10_1016_j_ifset_2015_09_009 crossref_primary_10_1128_msystems_00841_23 crossref_primary_10_3920_BM2015_0061 crossref_primary_10_1016_j_foodres_2021_110287 crossref_primary_10_1007_s00253_021_11278_y crossref_primary_10_1002_jsfa_7331 |
Cites_doi | 10.1172/JCI30587 10.1073/pnas.250406797 10.1017/S002202990002759X 10.1053/j.gastro.2005.03.044 10.1017/S0022029905000828 10.1074/jbc.M208241200 10.1073/pnas.97.2.799 10.1017/S0022029908003117 10.1159/000151505 10.1111/j.1365-2036.2006.03202.x 10.1093/jn/131.3.807 10.1016/j.imbio.2005.08.005 10.1017/S0022029901005210 10.1053/j.gastro.2004.04.018 10.1111/j.1365-2613.2007.00530.x 10.1038/nri1499 10.1016/j.bbrc.2006.02.080 10.2165/00003495-200666100-00006 10.1111/j.1365-2567.2006.02358.x 10.1016/j.ijfoodmicro.2007.07.042 10.1097/MOG.0b013e3282f0cffc 10.1097/MOG.0b013e3282f0153b 10.1053/gast.2002.31891 10.4049/jimmunol.171.7.3668 10.1073/pnas.241308598 10.1042/0264-6021:3460529 10.4049/jimmunol.181.3.2036 10.1371/journal.pone.0000313 10.1002/ibd.20377 10.1007/s10620-005-9016-x 10.4049/jimmunol.167.4.1882 |
ContentType | Journal Article |
Copyright | 2010 Elsevier B.V. 2015 INIST-CNRS Copyright 2010 Elsevier B.V. All rights reserved. |
Copyright_xml | – notice: 2010 Elsevier B.V. – notice: 2015 INIST-CNRS – notice: Copyright 2010 Elsevier B.V. All rights reserved. |
DBID | FBQ IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 7QL 7QO 7T7 8FD C1K FR3 M7N P64 |
DOI | 10.1016/j.ijfoodmicro.2010.04.014 |
DatabaseName | AGRIS Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biotechnology and BioEngineering Abstracts |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic Biotechnology Research Abstracts Technology Research Database Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Engineering Research Database Industrial and Applied Microbiology Abstracts (Microbiology A) Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management |
DatabaseTitleList | MEDLINE - Academic MEDLINE Biotechnology Research Abstracts |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: FBQ name: AGRIS url: http://www.fao.org/agris/Centre.asp?Menu_1ID=DB&Menu_2ID=DB1&Language=EN&Content=http://www.fao.org/agris/search?Language=EN sourceTypes: Publisher |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Economics Biology |
EISSN | 1879-3460 |
EndPage | 108 |
ExternalDocumentID | 10_1016_j_ijfoodmicro_2010_04_014 20471126 22896562 US201301850163 S0168160510002394 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GroupedDBID | --- --K --M .1- .~1 0R~ 1B1 1RT 1~. 1~5 29J 3EH 4.4 457 4G. 53G 5GY 5VS 7-5 71M 8P~ 9JM AAAJQ AABNK AABVA AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALCJ AALRI AAOAW AAQFI AAQXK AARKO AATLK AAXUO ABFNM ABFRF ABGRD ABMAC ABXDB ABYKQ ACDAQ ACGFO ACIUM ACIWK ACPRK ACRLP ADBBV ADEZE ADMUD ADQTV AEBSH AEFWE AEKER AENEX AEQOU AFCTW AFKWA AFRAH AFTJW AFXIZ AGEKW AGHFR AGUBO AGYEJ AHHHB AI. AIEXJ AIKHN AITUG AJBFU AJOXV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC CBWCG CJTIS CNWQP CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HLV HMG HVGLF HZ~ IHE J1W KOM LUGTX LW9 M41 MO0 N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. PQQKQ Q38 R2- RIG ROL RPZ SAB SDF SDG SES SEW SIN SPCBC SSA SSI SSZ T5K UBH VH1 WUQ XPP Y6R Z5R ~G- ~KM ABPIF ABPTK FBQ AJUYK IQODW AAHBH AAXKI AKRWK CGR CUY CVF ECM EIF NPM AAYXX AFJKZ CITATION 7X8 7QL 7QO 7T7 8FD C1K FR3 M7N P64 |
ID | FETCH-LOGICAL-c513t-3530763d0e97c5f3662367a7927afa5a8bd68143c4d5004f28b8c9f3181e0bac3 |
IEDL.DBID | AIKHN |
ISSN | 0168-1605 |
IngestDate | Fri Oct 25 00:54:14 EDT 2024 Fri Oct 25 01:45:14 EDT 2024 Thu Sep 26 16:30:15 EDT 2024 Sat Sep 28 08:17:07 EDT 2024 Sun Oct 22 16:07:34 EDT 2023 Wed Dec 27 19:06:26 EST 2023 Fri Feb 23 02:24:45 EST 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 2 |
Keywords | Innate response Inflammation Yeast Intestinal epithelium Kefir Probiotic |
Language | English |
License | CC BY 4.0 Copyright 2010 Elsevier B.V. All rights reserved. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c513t-3530763d0e97c5f3662367a7927afa5a8bd68143c4d5004f28b8c9f3181e0bac3 |
Notes | http://dx.doi.org/10.1016/j.ijfoodmicro.2010.04.014 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
OpenAccessLink | https://ri.conicet.gov.ar/bitstream/11336/136299/2/CONICET_Digital_Nro.78834df9-e73b-442d-b18f-eed0d726db4e_A.pdf |
PMID | 20471126 |
PQID | 733125457 |
PQPubID | 23479 |
PageCount | 7 |
ParticipantIDs | proquest_miscellaneous_745936847 proquest_miscellaneous_733125457 crossref_primary_10_1016_j_ijfoodmicro_2010_04_014 pubmed_primary_20471126 pascalfrancis_primary_22896562 fao_agris_US201301850163 elsevier_sciencedirect_doi_10_1016_j_ijfoodmicro_2010_04_014 |
PublicationCentury | 2000 |
PublicationDate | 2010-06-15 |
PublicationDateYYYYMMDD | 2010-06-15 |
PublicationDate_xml | – month: 06 year: 2010 text: 2010-06-15 day: 15 |
PublicationDecade | 2010 |
PublicationPlace | Amsterdam |
PublicationPlace_xml | – name: Amsterdam – name: Netherlands |
PublicationTitle | International journal of food microbiology |
PublicationTitleAlternate | Int J Food Microbiol |
PublicationYear | 2010 |
Publisher | Elsevier B.V [Amsterdam; New York, NY]: Elsevier Science Elsevier |
Publisher_xml | – name: Elsevier B.V – name: [Amsterdam; New York, NY]: Elsevier Science – name: Elsevier |
References | Nempont, Cayet, Rumbo, Bompard, Villeret, Sirard (bib20) 2008; 181 Schultz (bib24) 2008; 14 Buts (bib4) 2008; 5 Toki, Kagaya, Shinohara, Wakiguchi, Matsumoto, Takahata, Morimatsu, Saito, Matsumoto (bib31) 2008; 148 Anderle, Rumbo, Sierro, Mansourian, Michetti, Roberts, Kraehenbuhl (bib1) 2005; 129 Chapman, Plosker, Figgitt (bib6) 2006; 66 Golowczyc, Mobili, Garrote, Abraham, De Antoni (bib12) 2007; 118 Sougioultzis, Simeonidis, Bhaskar, Chen, Anton, Keates, Pothoulakis, Kelly (bib26) 2006; 343 Szajewska, Skorka, Dylag (bib28) 2007; 25 Taupin, Kinoshita, Podolsky (bib29) 2000; 97 Rumbo, Sierro, Debard, Kraehenbuhl, Finke (bib22) 2004; 127 Foligne, Zoumpopoulou, Dewulf, Ben Younes, Chareyre, Sirard, Pot, Grangette (bib9) 2007; 2 Sierro, Dubois, Coste, Kaiserlian, Kraehenbuhl, Sirard (bib25) 2001; 98 Thoreux, Schmucker (bib30) 2001; 131 McCole, Barrett (bib18) 2007; 23 Vinderola, Duarte, Thangavel, Perdigon, Farnworth, Matar (bib32) 2005; 72 Vinderola, Perdigon, Duarte, Thangavel, Farnworth, Matar (bib33) 2006; 211 Marcinkiewicz, Ciszek, Bobek, Strus, Heczko, Kurnyta, Biedron, Chmielarczyk (bib17) 2007; 88 O'Hara, O'Regan, Fanning, O'Mahony, Macsharry, Lyons, Bienenstock, O'Mahony, Shanahan (bib21) 2006; 118 Zeng, Carlson, Guo, Yu, Collier-Hyams, Madara, Gewirtz, Neish (bib35) 2003; 171 Buts, De Keyser (bib5) 2006; 51 Golowczyc, Gugliada, Hollmann, Delfederico, Garrote, Abraham, Semorile, De Antoni (bib13) 2008; 75 Kwon, Keates, Simeonidis, Grall, Libermann, Keates (bib14) 2003; 278 Lee, Kim, Chi, Joo, Kim (bib15) 2008; 10 Strober, Fuss, Mannon (bib27) 2007; 117 Farnworth (bib7) 2005; 2 Gewirtz, Navas, Lyons, Godowski, Madara (bib11) 2001; 167 Garrote, Abraham, De Antoni (bib10) 2001; 68 Boirivant, Strober (bib3) 2007; 23 Sansonetti (bib23) 2004; 4 Angulo, Lopez, Lema (bib2) 1993; 60 Felley-Bosco, Bender, Courjault-Gautier, Bron, Quest (bib8) 2000; 97 Maaser, Eckmann, Paesold, Kim, Kagnoff (bib16) 2002; 122 Mitchelmore, Troelsen, Spodsberg, Sjostrom, Noren (bib19) 2000; 346 Zanello, Meurens, Berri, Salmon (bib34) 2008; 11 Golowczyc (10.1016/j.ijfoodmicro.2010.04.014_bib12) 2007; 118 Strober (10.1016/j.ijfoodmicro.2010.04.014_bib27) 2007; 117 Sierro (10.1016/j.ijfoodmicro.2010.04.014_bib25) 2001; 98 Zanello (10.1016/j.ijfoodmicro.2010.04.014_bib34) 2008; 11 Boirivant (10.1016/j.ijfoodmicro.2010.04.014_bib3) 2007; 23 Farnworth (10.1016/j.ijfoodmicro.2010.04.014_bib7) 2005; 2 Foligne (10.1016/j.ijfoodmicro.2010.04.014_bib9) 2007; 2 Toki (10.1016/j.ijfoodmicro.2010.04.014_bib31) 2008; 148 Mitchelmore (10.1016/j.ijfoodmicro.2010.04.014_bib19) 2000; 346 Szajewska (10.1016/j.ijfoodmicro.2010.04.014_bib28) 2007; 25 Vinderola (10.1016/j.ijfoodmicro.2010.04.014_bib33) 2006; 211 Kwon (10.1016/j.ijfoodmicro.2010.04.014_bib14) 2003; 278 Zeng (10.1016/j.ijfoodmicro.2010.04.014_bib35) 2003; 171 Anderle (10.1016/j.ijfoodmicro.2010.04.014_bib1) 2005; 129 Chapman (10.1016/j.ijfoodmicro.2010.04.014_bib6) 2006; 66 Buts (10.1016/j.ijfoodmicro.2010.04.014_bib4) 2008; 5 Rumbo (10.1016/j.ijfoodmicro.2010.04.014_bib22) 2004; 127 Maaser (10.1016/j.ijfoodmicro.2010.04.014_bib16) 2002; 122 Marcinkiewicz (10.1016/j.ijfoodmicro.2010.04.014_bib17) 2007; 88 O'Hara (10.1016/j.ijfoodmicro.2010.04.014_bib21) 2006; 118 Garrote (10.1016/j.ijfoodmicro.2010.04.014_bib10) 2001; 68 McCole (10.1016/j.ijfoodmicro.2010.04.014_bib18) 2007; 23 Buts (10.1016/j.ijfoodmicro.2010.04.014_bib5) 2006; 51 Sansonetti (10.1016/j.ijfoodmicro.2010.04.014_bib23) 2004; 4 Nempont (10.1016/j.ijfoodmicro.2010.04.014_bib20) 2008; 181 Sougioultzis (10.1016/j.ijfoodmicro.2010.04.014_bib26) 2006; 343 Felley-Bosco (10.1016/j.ijfoodmicro.2010.04.014_bib8) 2000; 97 Schultz (10.1016/j.ijfoodmicro.2010.04.014_bib24) 2008; 14 Taupin (10.1016/j.ijfoodmicro.2010.04.014_bib29) 2000; 97 Golowczyc (10.1016/j.ijfoodmicro.2010.04.014_bib13) 2008; 75 Gewirtz (10.1016/j.ijfoodmicro.2010.04.014_bib11) 2001; 167 Angulo (10.1016/j.ijfoodmicro.2010.04.014_bib2) 1993; 60 Lee (10.1016/j.ijfoodmicro.2010.04.014_bib15) 2008; 10 Thoreux (10.1016/j.ijfoodmicro.2010.04.014_bib30) 2001; 131 Vinderola (10.1016/j.ijfoodmicro.2010.04.014_bib32) 2005; 72 |
References_xml | – volume: 51 start-page: 1485 year: 2006 end-page: 1492 ident: bib5 article-title: Effects of publication-title: Digestive Disease Science contributor: fullname: De Keyser – volume: 68 start-page: 639 year: 2001 end-page: 652 ident: bib10 article-title: Chemical and microbiological characterisation of kefir grains publication-title: Journal of Dairy Research contributor: fullname: De Antoni – volume: 211 start-page: 149 year: 2006 end-page: 156 ident: bib33 article-title: Effects of kefir fractions on innate immunity publication-title: Immunobiology contributor: fullname: Matar – volume: 98 start-page: 13722 year: 2001 end-page: 13727 ident: bib25 article-title: Flagellin stimulation of intestinal epithelial cells triggers CCL20-mediated migration of dendritic cells publication-title: Proceedings of the National Academy of Sciences of the United States of America contributor: fullname: Sirard – volume: 88 start-page: 155 year: 2007 end-page: 164 ident: bib17 article-title: Differential inflammatory mediator response in vitro from murine macrophages to lactobacilli and pathogenic intestinal bacteria publication-title: International Journal of Experimental Pathology contributor: fullname: Chmielarczyk – volume: 10 start-page: 10 year: 2008 ident: bib15 article-title: The effect of publication-title: Digestive Disease Science contributor: fullname: Kim – volume: 72 start-page: 195 year: 2005 end-page: 202 ident: bib32 article-title: Immunomodulating capacity of kefir publication-title: Journal of Dairy Research contributor: fullname: Matar – volume: 4 start-page: 953 year: 2004 end-page: 964 ident: bib23 article-title: War and peace at mucosal surfaces publication-title: Nature Reviews in Immunology contributor: fullname: Sansonetti – volume: 2 start-page: e313 year: 2007 ident: bib9 article-title: A key role of dendritic cells in probiotic functionality publication-title: PLoS ONE contributor: fullname: Grangette – volume: 25 start-page: 257 year: 2007 end-page: 264 ident: bib28 article-title: Meta-analysis: publication-title: Alimentary Pharmacological Therapeutics contributor: fullname: Dylag – volume: 167 start-page: 1882 year: 2001 end-page: 1885 ident: bib11 article-title: Bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression publication-title: Journal of Immunology contributor: fullname: Madara – volume: 171 start-page: 3668 year: 2003 end-page: 3674 ident: bib35 article-title: Flagellin is the major proinflammatory determinant of enteropathogenic publication-title: Journal of Immunology contributor: fullname: Neish – volume: 2 start-page: 1 year: 2005 end-page: 17 ident: bib7 article-title: Kefir — a complex probiotic publication-title: Food Science and Technology Bulletin contributor: fullname: Farnworth – volume: 122 start-page: 667 year: 2002 end-page: 680 ident: bib16 article-title: Ubiquitous production of macrophage migration inhibitory factor by human gastric and intestinal epithelium publication-title: Gastroenterology contributor: fullname: Kagnoff – volume: 97 start-page: 799 year: 2000 end-page: 804 ident: bib29 article-title: Intestinal trefoil factor confers colonic epithelial resistance to apoptosis publication-title: Proceedings of the National Academy of Sciences of the United States of America contributor: fullname: Podolsky – volume: 278 start-page: 875 year: 2003 end-page: 884 ident: bib14 article-title: ESE-1, an enterocyte-specific Ets transcription factor, regulates MIP-3alpha gene expression in Caco-2 human colonic epithelial cells publication-title: Journal of Biological Chemistry contributor: fullname: Keates – volume: 23 start-page: 647 year: 2007 end-page: 654 ident: bib18 article-title: Varied role of the gut epithelium in mucosal homeostasis publication-title: Current Opinion in Gastroenterology contributor: fullname: Barrett – volume: 129 start-page: 321 year: 2005 end-page: 327 ident: bib1 article-title: Novel markers of the human follicle-associated epithelium identified by genomic profiling and microdissection publication-title: Gastroenterology contributor: fullname: Kraehenbuhl – volume: 23 start-page: 679 year: 2007 end-page: 692 ident: bib3 article-title: The mechanism of action of probiotics publication-title: Current Opinion in Gastroenterology contributor: fullname: Strober – volume: 131 start-page: 807 year: 2001 end-page: 812 ident: bib30 article-title: Kefir milk enhances intestinal immunity in young but not old rats publication-title: Journal of Nutrition contributor: fullname: Schmucker – volume: 181 start-page: 2036 year: 2008 end-page: 2043 ident: bib20 article-title: Deletion of flagellin's hypervariable region abrogates antibody-mediated neutralization and systemic activation of TLR5-dependent immunity publication-title: Journal of Immunology contributor: fullname: Sirard – volume: 343 start-page: 69 year: 2006 end-page: 76 ident: bib26 article-title: publication-title: Biochemical and Biophysical Research Communications contributor: fullname: Kelly – volume: 60 start-page: 263 year: 1993 end-page: 267 ident: bib2 article-title: Microflora present in kefir grains of the Galician region (north-west of Spain) publication-title: Journal of Dairy Research contributor: fullname: Lema – volume: 97 start-page: 14334 year: 2000 end-page: 14339 ident: bib8 article-title: Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells publication-title: Proceedings of the National Academy of Sciences of the United States of America contributor: fullname: Quest – volume: 127 start-page: 213 year: 2004 end-page: 223 ident: bib22 article-title: Lymphotoxin beta receptor signaling induces the chemokine CCL20 in intestinal epithelium publication-title: Gastroenterology contributor: fullname: Finke – volume: 118 start-page: 202 year: 2006 end-page: 215 ident: bib21 article-title: Functional modulation of human intestinal epithelial cell responses by publication-title: Immunology contributor: fullname: Shanahan – volume: 118 start-page: 264 year: 2007 end-page: 273 ident: bib12 article-title: Protective action of publication-title: International Journal of Food Microbiology contributor: fullname: De Antoni – volume: 75 start-page: 211 year: 2008 end-page: 217 ident: bib13 article-title: Characterization of homofermentative lactobacilli isolated from kefir grains: potential use as probiotic publication-title: Journal of Dairy Research contributor: fullname: De Antoni – volume: 346 start-page: 529 year: 2000 end-page: 535 ident: bib19 article-title: Interaction between the homeodomain proteins Cdx2 and HNF1 alpha mediates expression of the lactase-phlorizin hydrolase gene publication-title: Biochemical Journal contributor: fullname: Noren – volume: 148 start-page: 45 year: 2008 end-page: 58 ident: bib31 article-title: Lactobacillus rhamnosus GG and publication-title: International Archives of Allergy and Immunology contributor: fullname: Matsumoto – volume: 66 start-page: 1371 year: 2006 end-page: 1387 ident: bib6 article-title: VSL#3 probiotic mixture: a review of its use in chronic inflammatory bowel diseases publication-title: Drugs contributor: fullname: Figgitt – volume: 5 start-page: 5 year: 2008 ident: bib4 article-title: Twenty-five years of research on publication-title: Digestive Disease Science contributor: fullname: Buts – volume: 117 start-page: 514 year: 2007 end-page: 521 ident: bib27 article-title: The fundamental basis of inflammatory bowel disease publication-title: Journal of Clinical Investigation contributor: fullname: Mannon – volume: 14 start-page: 1012 year: 2008 end-page: 1018 ident: bib24 article-title: Clinical use of publication-title: Inflammatory Bowel Disease contributor: fullname: Schultz – volume: 11 start-page: 47 year: 2008 end-page: 58 ident: bib34 article-title: publication-title: Current Issues on Molecular Biology contributor: fullname: Salmon – volume: 117 start-page: 514 year: 2007 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib27 article-title: The fundamental basis of inflammatory bowel disease publication-title: Journal of Clinical Investigation doi: 10.1172/JCI30587 contributor: fullname: Strober – volume: 97 start-page: 14334 year: 2000 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib8 article-title: Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.250406797 contributor: fullname: Felley-Bosco – volume: 60 start-page: 263 year: 1993 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib2 article-title: Microflora present in kefir grains of the Galician region (north-west of Spain) publication-title: Journal of Dairy Research doi: 10.1017/S002202990002759X contributor: fullname: Angulo – volume: 11 start-page: 47 year: 2008 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib34 article-title: Saccharomyces boulardii effects on gastrointestinal diseases publication-title: Current Issues on Molecular Biology contributor: fullname: Zanello – volume: 129 start-page: 321 year: 2005 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib1 article-title: Novel markers of the human follicle-associated epithelium identified by genomic profiling and microdissection publication-title: Gastroenterology doi: 10.1053/j.gastro.2005.03.044 contributor: fullname: Anderle – volume: 72 start-page: 195 year: 2005 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib32 article-title: Immunomodulating capacity of kefir publication-title: Journal of Dairy Research doi: 10.1017/S0022029905000828 contributor: fullname: Vinderola – volume: 278 start-page: 875 year: 2003 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib14 article-title: ESE-1, an enterocyte-specific Ets transcription factor, regulates MIP-3alpha gene expression in Caco-2 human colonic epithelial cells publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M208241200 contributor: fullname: Kwon – volume: 97 start-page: 799 year: 2000 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib29 article-title: Intestinal trefoil factor confers colonic epithelial resistance to apoptosis publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.97.2.799 contributor: fullname: Taupin – volume: 75 start-page: 211 year: 2008 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib13 article-title: Characterization of homofermentative lactobacilli isolated from kefir grains: potential use as probiotic publication-title: Journal of Dairy Research doi: 10.1017/S0022029908003117 contributor: fullname: Golowczyc – volume: 5 start-page: 5 year: 2008 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib4 article-title: Twenty-five years of research on Saccharomyces boulardii trophic effects: updates and perspectives publication-title: Digestive Disease Science contributor: fullname: Buts – volume: 2 start-page: 1 year: 2005 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib7 article-title: Kefir — a complex probiotic publication-title: Food Science and Technology Bulletin contributor: fullname: Farnworth – volume: 148 start-page: 45 year: 2008 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib31 article-title: Lactobacillus rhamnosus GG and Lactobacillus casei suppress Escherichia coli-induced chemokine expression in intestinal epithelial cells publication-title: International Archives of Allergy and Immunology doi: 10.1159/000151505 contributor: fullname: Toki – volume: 25 start-page: 257 year: 2007 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib28 article-title: Meta-analysis: Saccharomyces boulardii for treating acute diarrhoea in children publication-title: Alimentary Pharmacological Therapeutics doi: 10.1111/j.1365-2036.2006.03202.x contributor: fullname: Szajewska – volume: 131 start-page: 807 year: 2001 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib30 article-title: Kefir milk enhances intestinal immunity in young but not old rats publication-title: Journal of Nutrition doi: 10.1093/jn/131.3.807 contributor: fullname: Thoreux – volume: 211 start-page: 149 year: 2006 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib33 article-title: Effects of kefir fractions on innate immunity publication-title: Immunobiology doi: 10.1016/j.imbio.2005.08.005 contributor: fullname: Vinderola – volume: 68 start-page: 639 year: 2001 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib10 article-title: Chemical and microbiological characterisation of kefir grains publication-title: Journal of Dairy Research doi: 10.1017/S0022029901005210 contributor: fullname: Garrote – volume: 127 start-page: 213 year: 2004 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib22 article-title: Lymphotoxin beta receptor signaling induces the chemokine CCL20 in intestinal epithelium publication-title: Gastroenterology doi: 10.1053/j.gastro.2004.04.018 contributor: fullname: Rumbo – volume: 88 start-page: 155 year: 2007 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib17 article-title: Differential inflammatory mediator response in vitro from murine macrophages to lactobacilli and pathogenic intestinal bacteria publication-title: International Journal of Experimental Pathology doi: 10.1111/j.1365-2613.2007.00530.x contributor: fullname: Marcinkiewicz – volume: 4 start-page: 953 year: 2004 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib23 article-title: War and peace at mucosal surfaces publication-title: Nature Reviews in Immunology doi: 10.1038/nri1499 contributor: fullname: Sansonetti – volume: 343 start-page: 69 year: 2006 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib26 article-title: Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-kappaB-mediated IL-8 gene expression publication-title: Biochemical and Biophysical Research Communications doi: 10.1016/j.bbrc.2006.02.080 contributor: fullname: Sougioultzis – volume: 66 start-page: 1371 year: 2006 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib6 article-title: VSL#3 probiotic mixture: a review of its use in chronic inflammatory bowel diseases publication-title: Drugs doi: 10.2165/00003495-200666100-00006 contributor: fullname: Chapman – volume: 118 start-page: 202 year: 2006 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib21 article-title: Functional modulation of human intestinal epithelial cell responses by Bifidobacterium infantis and Lactobacillus salivarius publication-title: Immunology doi: 10.1111/j.1365-2567.2006.02358.x contributor: fullname: O'Hara – volume: 10 start-page: 10 year: 2008 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib15 article-title: The effect of Saccharomyces boulardii on human colon cells and inflammation in rats with trinitrobenzene sulfonic acid-induced colitis publication-title: Digestive Disease Science contributor: fullname: Lee – volume: 118 start-page: 264 year: 2007 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib12 article-title: Protective action of Lactobacillus kefir carrying S-layer protein against Salmonella enterica serovar enteritidis publication-title: International Journal of Food Microbiology doi: 10.1016/j.ijfoodmicro.2007.07.042 contributor: fullname: Golowczyc – volume: 23 start-page: 679 year: 2007 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib3 article-title: The mechanism of action of probiotics publication-title: Current Opinion in Gastroenterology doi: 10.1097/MOG.0b013e3282f0cffc contributor: fullname: Boirivant – volume: 23 start-page: 647 year: 2007 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib18 article-title: Varied role of the gut epithelium in mucosal homeostasis publication-title: Current Opinion in Gastroenterology doi: 10.1097/MOG.0b013e3282f0153b contributor: fullname: McCole – volume: 122 start-page: 667 year: 2002 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib16 article-title: Ubiquitous production of macrophage migration inhibitory factor by human gastric and intestinal epithelium publication-title: Gastroenterology doi: 10.1053/gast.2002.31891 contributor: fullname: Maaser – volume: 171 start-page: 3668 year: 2003 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib35 article-title: Flagellin is the major proinflammatory determinant of enteropathogenic Salmonella publication-title: Journal of Immunology doi: 10.4049/jimmunol.171.7.3668 contributor: fullname: Zeng – volume: 98 start-page: 13722 year: 2001 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib25 article-title: Flagellin stimulation of intestinal epithelial cells triggers CCL20-mediated migration of dendritic cells publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.241308598 contributor: fullname: Sierro – volume: 346 start-page: 529 year: 2000 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib19 article-title: Interaction between the homeodomain proteins Cdx2 and HNF1 alpha mediates expression of the lactase-phlorizin hydrolase gene publication-title: Biochemical Journal doi: 10.1042/0264-6021:3460529 contributor: fullname: Mitchelmore – volume: 181 start-page: 2036 year: 2008 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib20 article-title: Deletion of flagellin's hypervariable region abrogates antibody-mediated neutralization and systemic activation of TLR5-dependent immunity publication-title: Journal of Immunology doi: 10.4049/jimmunol.181.3.2036 contributor: fullname: Nempont – volume: 2 start-page: e313 year: 2007 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib9 article-title: A key role of dendritic cells in probiotic functionality publication-title: PLoS ONE doi: 10.1371/journal.pone.0000313 contributor: fullname: Foligne – volume: 14 start-page: 1012 year: 2008 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib24 article-title: Clinical use of E. coli Nissle 1917 in inflammatory bowel disease publication-title: Inflammatory Bowel Disease doi: 10.1002/ibd.20377 contributor: fullname: Schultz – volume: 51 start-page: 1485 year: 2006 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib5 article-title: Effects of Saccharomyces boulardii on intestinal mucosa publication-title: Digestive Disease Science doi: 10.1007/s10620-005-9016-x contributor: fullname: Buts – volume: 167 start-page: 1882 year: 2001 ident: 10.1016/j.ijfoodmicro.2010.04.014_bib11 article-title: Bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression publication-title: Journal of Immunology doi: 10.4049/jimmunol.167.4.1882 contributor: fullname: Gewirtz |
SSID | ssj0005330 |
Score | 2.3392744 |
Snippet | Kefir is obtained by milk fermentation with a complex microbial population included in a matrix of polysaccharide and proteins. Several health-promoting... |
SourceID | proquest crossref pubmed pascalfrancis fao elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 102 |
SubjectTerms | Animal models Animals anti-inflammatory activity Bacteria - classification Bacteria - immunology Bacteria - isolation & purification Biological and medical sciences Caco-2 Cells cell culture Chemokine CCL20 - genetics Chemokine CCL20 - immunology Chemokine CXCL2 - genetics Chemokine CXCL2 - immunology Cultured Milk Products - microbiology Down-Regulation Epithelial Cells - immunology Epithelial Cells - microbiology Female Food industries Food microbiology functional foods Fundamental and applied biological sciences. Psychology gene expression regulation HT29 Cells human cell lines Humans Immunity, Innate Inflammation Innate response Intestinal epithelium intestinal mucosa Intestines - cytology Intestines - immunology Intestines - microbiology isolation Issatchenkia Kefir Mice Mice, Inbred BALB C Molecular Sequence Data mucosal immunity NF-kappa B - genetics NF-kappa B - immunology probiotics Probiotics - isolation & purification Yeast yeasts Yeasts - classification Yeasts - immunology Yeasts - isolation & purification |
Title | Down-regulation of intestinal epithelial innate response by probiotic yeasts isolated from kefir |
URI | https://dx.doi.org/10.1016/j.ijfoodmicro.2010.04.014 https://www.ncbi.nlm.nih.gov/pubmed/20471126 https://search.proquest.com/docview/733125457 https://search.proquest.com/docview/745936847 |
Volume | 140 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB51t-JxQVAeDY-Vkbi6u7EdJ5G4VIVqAdFLWak34yR2lQLJand72Au_nZk4YemhCIlrZDuJv5nxZ3nGH8Abl9oiLVPBdSoqrqzIuC1cziuV-U6_KPZUnPz5TM8X6uNFcrEHJ0MtDKVV9rE_xPQuWvdPpv1sTpd1PT1HspLFmowqCHyPYB-XI6XGsH_84dP8bJfpITvJEWrPqcNdeL1L86qvfNtWPyj7rU_0UkezWN22TI28bSl_0q5xCn3QvridnHaL1OlDeNCzS3YcfuAR7LnmAO4EvcntAdwbypDXj-HrO9x_81WQokdwWOsZ3R2BLk9DuCUVa3xH68SnDRJStgrZtI4VW7bsbm_Cl7Ataf-sWY0mjI0qRuUq7Jvz9eoJLE7ffzmZ815ugZdJLDdcJujvWlYzl6dl4qXWdLubTXORWm8TmxUVTriSpaoSdC0vsiIrc49BIXazwpbyKYybtnGHwBLpEXupcLdSKFflVjsnCptp0lrHQSMQw-yaZbhVwwzpZlfmD0gMQWJmyiAkEbwdcDA3TMRg9P-X7oeInbGXGDzN4lzQkS2SFewjI5jcAPT3NwncjiLhFRGwAWGD7kdnKrZx7fXakOQl7rGT9C9NFKkmIguI4Fkwjt34M-QGsdDP_-_XXsD9kNSgeZy8hPFmde1eIVfaFBMYHf2MJ71H_AKQTBL_ |
link.rule.ids | 315,786,790,4521,24144,27955,27956,45618,45712 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Nb9QwEB21RVAuCMpHw0cxEld3E9txEokLKlQLtL20K_VmnMRGKZCsdreHvfDbmYkT2h6KkLhGjjfrNzN5Vt74Abx1mS2zKhNcZ6Lmyoqc29IVvFa57_2LEk_NyccnejpTn8_T8w04GHthSFY51P5Q0_tqPVyZDKs5mTfN5BTJSp5oCqpg8L0Jd4gNkK5r_9c1nYfsDUdoNKfh9-DNlcirufBdV_8k7dsg81L7caJue0ltetuRetIucQF9cL64nZr2r6jDh_Bg4JbsfXj8R7Dh2h24G9wm1zuwPTYhLx_D1w-4--aLYESP0LDOMzo5AhOepnBzatX4gbGJV1uko2wRtLSOlWs2789uwh9ha3L-WbIGAxgH1YyaVdh355vFE5gdfjw7mPLBbIFXaSJXXKaY7VrWsSuyKvVSazrbzWaFyKy3qc3LGpdbyUrVKSaWF3mZV4XHkpC4uLSVfApbbde6XWCp9Ii8VLhXKZWrC6udE6XNNTmt46QRiHF1zTycqWFGsdmFuQaJIUhMrAxCEsG7EQdzI0AM1v5_uX0XsTP2G5ZOMzsV9MEWqQreIyPYuwHon2cSuBlFuisiYCPCBpOPvqjY1nWXS0OGl7jDTrO_DFHkmYgcIIJnITiu5o-RGSRCP_-_v_Yatqdnx0fm6NPJlxdwP8gbNE_Sl7C1Wly6V8iaVuVenxW_AQT_E9Q |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Down-regulation+of+intestinal+epithelial+innate+response+by+probiotic+yeasts+isolated+from+kefir&rft.jtitle=International+journal+of+food+microbiology&rft.au=Romanin%2C+David&rft.au=Serradell%2C+Mar%C3%ADa&rft.au=Gonz%C3%A1lez+Maciel%2C+Dolores&rft.au=Lausada%2C+Natalia&rft.date=2010-06-15&rft.eissn=1879-3460&rft.volume=140&rft.issue=2-3&rft.spage=102&rft_id=info:doi/10.1016%2Fj.ijfoodmicro.2010.04.014&rft_id=info%3Apmid%2F20471126&rft.externalDocID=20471126 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0168-1605&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0168-1605&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0168-1605&client=summon |