Genetic determinants in the metabolism of bladder carcinogens in relation to risk of bladder cancer

• Published in: Carcinogenesis (New York) Vol. 29; no. 7; pp. 1386 - 1393
• Main Authors: Yuan, Jian-Min, Chan, Kenneth K., Coetzee, Gerhard A., Castelao, J.Esteban, Watson, Mary A., Bell, Douglas A., Wang, Renwei, Yu, Mimi C.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.07.2008; Oxford Publishing Limited (England)
• Subjects: Adult; Arylamine N-Acetyltransferase - genetics; Arylamine N-Acetyltransferase - metabolism; Biological and medical sciences; Bladder cancer; Carcinogenesis, carcinogens and anticarcinogens; Carcinogens - metabolism; Carcinoma, Transitional Cell - chemically induced; Carcinoma, Transitional Cell - enzymology; Carcinoma, Transitional Cell - genetics; Case-Control Studies; Chemical agents; Cytochrome P-450 CYP1A2 - genetics; Cytochrome P-450 CYP1A2 - metabolism; Female; Genetic Predisposition to Disease; Glutathione Transferase - genetics; Glutathione Transferase - metabolism; Humans; Isoenzymes - genetics; Isoenzymes - metabolism; Male; Medical sciences; Middle Aged; Molecular Epidemiology; Nephrology. Urinary tract diseases; Tumors; Tumors of the urinary system; Urinary Bladder - drug effects; Urinary Bladder - enzymology; Urinary Bladder Neoplasms - chemically induced; Urinary Bladder Neoplasms - enzymology; Urinary Bladder Neoplasms - genetics; Urinary system involvement in other diseases. Miscellaneous; Urinary tract. Prostate gland; Urinary system disease; Toxicity; Risk; Urinary tract disease; Malignant tumor; Metabolism; Bladder cancer; Genetic determinism; Carcinogen; Urinary system; Urinary bladder; Risk factor; Bladder disease; Cancer

Genetically determined factors that alter the metabolism of tobacco carcinogens can influence an individual’s susceptibility to bladder cancer. The associations between the genotypes of glutathione S-transferase (GST) M1, GSTP1, GSTT1 and N-acetyltransferase (NAT) 1 and the phenotypes of NAT2 and cy...