Benzolactam-related compounds promote apoptosis of HIV-infected human cells via protein kinase C–induced HIV latency reversal

• Published in: The Journal of biological chemistry Vol. 294; no. 1; pp. 116 - 129
• Main Authors: Matsuda, Kouki, Kobayakawa, Takuya, Tsuchiya, Kiyoto, Hattori, Shin-ichiro, Nomura, Wataru, Gatanaga, Hiroyuki, Yoshimura, Kazuhisa, Oka, Shinichi, Endo, Yasuyuki, Tamamura, Hirokazu, Mitsuya, Hiroaki, Maeda, Kenji
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 04.01.2019; American Society for Biochemistry and Molecular Biology
• Subjects: antiviral agent; apoptosis; Apoptosis - drug effects; Benzodiazepinones - pharmacology; benzolactam; Caspase 3 - biosynthesis; Caspase 3 - genetics; CD4-Positive T-Lymphocytes - metabolism; CD4-Positive T-Lymphocytes - pathology; CD4-Positive T-Lymphocytes - virology; Cell Cycle Proteins; Developmental Biology; Female; Gene Expression Regulation, Enzymologic - drug effects; HIV cure; HIV Infections - genetics; HIV Infections - metabolism; HIV Infections - pathology; HIV-1 - physiology; human immunodeficiency virus (HIV); Humans; latency-reversing agents; latent infection; Male; Nuclear Proteins - antagonists & inhibitors; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; PKC activator; protein kinase C (PKC); Protein Kinase C - genetics; Protein Kinase C - metabolism; retrovirus; Transcription Factors - antagonists & inhibitors; Transcription Factors - genetics; Transcription Factors - metabolism; Virus Latency - drug effects; retrovirus; benzolactam; human immunodeficiency virus (HIV); protein kinase C (PKC); PKC activator; apoptosis; antiviral agent; latency-reversing agents; latent infection; HIV cure

Latency-reversing agents (LRAs) are considered a potential strategy for curing cells of HIV-1 infection. Certain protein kinase C (PKC) activators have been previously reported to be LRAs because they can reverse HIV latency. In the present study, we examined the activities of a panel of benzolactam...