Impairment of human terminal erythroid differentiation by histone deacetylase 5 deficiency

• Published in: Blood Vol. 138; no. 17; pp. 1615 - 1627
• Main Authors: Wang, Yaomei, Li, Wei, Schulz, Vincent P., Zhao, Huizhi, Qu, Xiaoli, Qi, Qian, Cheng, Yong, Guo, Xinhua, Zhang, Shijie, Wei, Xin, Liu, Donghao, Yazdanbakhsh, Karina, Hillyer, Christopher D., Mohandas, Narla, Chen, Lixiang, Gallagher, Patrick G., An, Xiuli
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 28.10.2021; American Society of Hematology
• Subjects: Apoptosis; Erythroblasts - cytology; Erythroblasts - metabolism; Erythroid Cells - cytology; Erythroid Cells - metabolism; Erythropoiesis; Histone Deacetylases - genetics; Humans; Red Cells, Iron, and Erythropoiesis; RNA Interference; RNA, Small Interfering - genetics; Up-Regulation

Histone deacetylases (HDACs) are a group of enzymes that catalyze the removal of acetyl groups from histone and nonhistone proteins. HDACs have been shown to have diverse functions in a wide range of biological processes. However, their roles in mammalian erythropoiesis remain to be fully defined. T...