Gonadotropin-releasing hormone agonist may minimize premature ovarian failure in young women undergoing autologous stem cell transplantation

• Published in: Fertility and sterility Vol. 98; no. 5; pp. 1266 - 1270.e1
• Main Authors: Blumenfeld, Zeev, M.D, Patel, Biren, M.D, Leiba, Ronit, M.Sc, Zuckerman, Tsila, M.D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.11.2012; Elsevier
• Subjects: Adult; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Bone marrow, stem cells transplantation. Graft versus host reaction; Case-Control Studies; Chi-Square Distribution; Diseases of mother, fetus and pregnancy; Female; Fertility Agents, Female - therapeutic use; Fertility preservation; Fertility Preservation - methods; GnRH-agonist; gonadotoxicity; Gonadotropin-Releasing Hormone - agonists; Gonadotropin-Releasing Hormone - metabolism; Gynecology. Andrology. Obstetrics; Humans; Internal Medicine; Israel; Leukemia - mortality; Leukemia - therapy; Lymphoma - mortality; Lymphoma - therapy; Medical sciences; Obstetrics and Gynecology; Ovary - drug effects; Ovary - metabolism; Ovary - physiopathology; Pregnancy. Fetus. Placenta; premature ovarian failure (POF); Primary Ovarian Insufficiency - etiology; Primary Ovarian Insufficiency - metabolism; Primary Ovarian Insufficiency - physiopathology; Primary Ovarian Insufficiency - prevention & control; Prospective Studies; Risk Assessment; Risk Factors; stem cell transplantation (SCT); Stem Cell Transplantation - adverse effects; Time Factors; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Transplantation Conditioning - adverse effects; Treatment Outcome; Triptorelin Pamoate - therapeutic use; Israel; gonadotoxicity; Fertility preservation; premature ovarian failure (POF); GnRH-agonist; stem cell transplantation (SCT); Endocrinopathy; Human; Premature; Agonist; Preservation; Gynecology; Gonadotropin RH; Stem cell transplantation; Obstetrics; Female genital diseases; Ovarian diseases; Autograft; Ovarian failure; Fertility; Female; Woman

Objective To compare the rate of premature ovarian failure (POF) after stem cell transplantation (SCT) in young women receiving GnRH-agonist (GnRH-a) in conjunction with gonadotoxic chemotherapy. Design Prospective, nonrandomized study. Setting Tertiary university hospital. Patient(s) Ninety-five wo...