Novel Vaccines Targeting the Highly Conserved SARS-CoV-2 ORF3a Ectodomain Elicit Immunogenicity in Mouse Models - Meza, Jacob; Glass, Elizabeth; Sandhu, Avinaash K.; Li, Yangchen; Karanika, Styliani; Fessler, Kaitlyn; Hui, Yinan; Schill, Courtney; Wang, Tianyin; Zhang, Jiaqi; Bates, Rowan E.; Taylor, Alannah D.; et al. (Vaccines (Basel), 2025)
Keywords: Adjuvants; Amino acids; Analysis; Animal diseases; Animal models; Antibodies; Antibody response; Antigens; Bacteria; Cells; Chemokines; COVID-19; COVID-19 vaccines; CpG islands; Dendritic cells; Deoxyribonucleic acid; Disease; Disease control; DNA; DNA vaccine; DNA vaccines; Dosage and administration; E coli; Electroporation; Enzymes; Evolution; Genetic drift; Immune response; Immunity (Disease); Immunogenicity; KLH; Laboratory animals; Lungs; Lymphocytes; Lymphocytes T; Macrophages; Medical research; MIP protein; MIP3?/CCL20; ORF3a; Pathogenesis; Peptides; Proteins; Robustness; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Spike protein; Testing; Vaccines; Virions; United States; United States--US; COVID-19; DNA vaccine; MIP3α/CCL20; SARS-CoV-2; antibody response; evolutionarily conserved antigen; KLH; peptide vaccine; ORF3a; T-cell response