Multilocus genetic composite reflecting dopamine signaling capacity predicts reward circuitry responsivity

• Published in: The Journal of neuroscience Vol. 32; no. 29; pp. 10093 - 10100
• Main Authors: Stice, Eric, Yokum, Sonja, Burger, Kyle, Epstein, Leonard, Smolen, Andy
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 18.07.2012
• Subjects: Adolescent; Alleles; Brain - physiology; Brain Mapping; Female; Genotype; Humans; Magnetic Resonance Imaging; Male; Polymorphism, Single Nucleotide; Receptors, Dopamine D2 - genetics; Receptors, Dopamine D4 - genetics; Reward; Signal Transduction - genetics

The objective of the study was to test the hypotheses that humans with genotypes putatively associated with low dopamine (DA) signaling capacity, including the TaqIA A1 allele, DRD2-141C Ins/Ins genotype, DRD4 7-repeat or longer allele, DAT1 10-repeat allele, and the Met/Met COMT genotype, and with...