Nef Induces Multiple Genes Involved in Cholesterol Synthesis and Uptake in Human Immunodeficiency Virus Type 1-Infected T Cells
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from...
Saved in:
| Published in | Journal of Virology Vol. 79; no. 15; pp. 10053 - 10058 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Washington, DC
American Society for Microbiology
01.08.2005
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Article Usage Stats
Services
JVI
Citing Articles
Google Scholar
PubMed
Related Content
Social Bookmarking
CiteULike
Delicious
Digg
Facebook
Google+
Mendeley
Reddit
StumbleUpon
Twitter
current issue
Spotlights in the Current Issue
JVI
About
JVI
Subscribers
Authors
Reviewers
Advertisers
Inquiries from the Press
Permissions & Commercial Reprints
ASM Journals Public Access Policy
JVI
RSS Feeds
1752 N Street N.W. • Washington DC 20036
202.737.3600 • 202.942.9355 fax • journals@asmusa.org
Print ISSN:
0022-538X
Online ISSN:
1098-5514
Copyright © 2014
by the
American Society for Microbiology.
For an alternate route to
JVI
.asm.org, visit:
JVI
|
|---|---|
| AbstractList | Article Usage Stats
Services
JVI
Citing Articles
Google Scholar
PubMed
Related Content
Social Bookmarking
CiteULike
Delicious
Digg
Facebook
Google+
Mendeley
Reddit
StumbleUpon
Twitter
current issue
Spotlights in the Current Issue
JVI
About
JVI
Subscribers
Authors
Reviewers
Advertisers
Inquiries from the Press
Permissions & Commercial Reprints
ASM Journals Public Access Policy
JVI
RSS Feeds
1752 N Street N.W. • Washington DC 20036
202.737.3600 • 202.942.9355 fax • journals@asmusa.org
Print ISSN:
0022-538X
Online ISSN:
1098-5514
Copyright © 2014
by the
American Society for Microbiology.
For an alternate route to
JVI
.asm.org, visit:
JVI
ABSTRACT Several recent reports indicate that cholesterol might play an important role in human immunodeficiency virus type 1 (HIV-1) replication. We investigated the effects of HIV-1 infection on cholesterol biosynthesis and uptake using microarrays. HIV-1 increased gene expression of cholesterol genes in both transformed T-cell lines and primary CD4 + T cells. Consistent with our microarray data, 14 C-labeled mevalonate and acetate incorporation was increased in HIV-1-infected cells. Our data also demonstrate that changes in cholesterol biosynthesis and uptake are only observed in the presence of functional Nef, suggesting that increased cholesterol synthesis may contribute to Nef-mediated enhancement of virion infectivity and viral replication. Several recent reports indicate that cholesterol might play an important role in human immunodeficiency virus type 1 (HIV-1) replication. We investigated the effects of HIV-1 infection on cholesterol biosynthesis and uptake using microarrays. HIV-1 increased gene expression of cholesterol genes in both transformed T-cell lines and primary CD4 + T cells. Consistent with our microarray data, 14 C-labeled mevalonate and acetate incorporation was increased in HIV-1-infected cells. Our data also demonstrate that changes in cholesterol biosynthesis and uptake are only observed in the presence of functional Nef, suggesting that increased cholesterol synthesis may contribute to Nef-mediated enhancement of virion infectivity and viral replication. Several recent reports indicate that cholesterol might play an important role in human immunodeficiency virus type 1 (HIV-1) replication. We investigated the effects of HIV-1 infection on cholesterol biosynthesis and uptake using microarrays. HIV-1 increased gene expression of cholesterol genes in both transformed T-cell lines and primary CD4 super(+) T cells. Consistent with our microarray data, super(14)C-labeled mevalonate and acetate incorporation was increased in HIV-1-infected cells. Our data also demonstrate that changes in cholesterol biosynthesis and uptake are only observed in the presence of functional Nef, suggesting that increased cholesterol synthesis may contribute to Nef-mediated enhancement of virion infectivity and viral replication. Several recent reports indicate that cholesterol might play an important role in human immunodeficiency virus type 1 (HIV-1) replication. We investigated the effects of HIV-1 infection on cholesterol biosynthesis and uptake using microarrays. HIV-1 increased gene expression of cholesterol genes in both transformed T-cell lines and primary CD4(+) T cells. Consistent with our microarray data, (14)C-labeled mevalonate and acetate incorporation was increased in HIV-1-infected cells. Our data also demonstrate that changes in cholesterol biosynthesis and uptake are only observed in the presence of functional Nef, suggesting that increased cholesterol synthesis may contribute to Nef-mediated enhancement of virion infectivity and viral replication. |
| Author | Ushnal Rao Michael Schindler Angélique B. van ′t Wout Melissa S. Pathmajeyan Frank Kirchhoff James I. Mullins J. Victor Swain |
| AuthorAffiliation | Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-8070, 1 Department of Virology, Universitatsklinikum, 89081 Ulm, Germany 2 |
| AuthorAffiliation_xml | – name: Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-8070, 1 Department of Virology, Universitatsklinikum, 89081 Ulm, Germany 2 |
| Author_xml | – sequence: 1 givenname: Angélique B surname: VAN 'T WOUT fullname: VAN 'T WOUT, Angélique B organization: Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-8070, United States – sequence: 2 givenname: J. Victor surname: SWAIN fullname: SWAIN, J. Victor organization: Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-8070, United States – sequence: 3 givenname: Michael surname: SCHINDLER fullname: SCHINDLER, Michael organization: Department of Virology, Universitatsklinikum, 89081 Ulm, Germany – sequence: 4 givenname: Ushnal surname: RAO fullname: RAO, Ushnal organization: Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-8070, United States – sequence: 5 givenname: Melissa S surname: PATHMAJEYAN fullname: PATHMAJEYAN, Melissa S organization: Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-8070, United States – sequence: 6 givenname: James I surname: MULLINS fullname: MULLINS, James I organization: Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-8070, United States – sequence: 7 givenname: Frank surname: KIRCHHOFF fullname: KIRCHHOFF, Frank organization: Department of Virology, Universitatsklinikum, 89081 Ulm, Germany |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16956653$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/16014965$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkUFv1DAQhS1URLeFv4AsEL0l2EnsOBwqoRW0QQUObCtulmtPGpfECXay1Z7463i7K1hOXMa2_M0bP78TdOQGBwi9oiSlNBNvP93UaVmllKWUEJYn2yrSLNYnaEFJJRLGaHGEFoRkWcJy8f0YnYRwTwgtCl48Q8eUx23F2QL9-gINrp2ZNQT8ee4mO3aAL8DFY-3WQ7cGg63Dy3boIEzghw5_27iphWADVs7g63FSP2DLXM69crju-9kNBhqrLTi9wTfWzwGvNiNgmtSuAT1FzRVeQteF5-hpo7oAL_brKbr--GG1vEyuvl7Uy_dXiWY0nxJaNIbpTBkmSl6CKRrGVKaI0gXn3OSFMCXXDIgwt0RVDSHGFLQqWROdxob8FJ3vdMf5tgejwU1edXL0tld-Iwdl5b83zrbyblhLSgVlVRkFzvYCfvg5x6-QvQ06WlAOhjlILkhOKv5_kJa5oBkpIvhuB2o_hOCh-fMaSuQ2aBmDlmUlKZOPQT9WIbdBx-aXh37-tu6TjcCbPaCCVl3jldM2HHAV4xGL3Osd19q79sF6kCr08n5tDyfnvwHIcMDw |
| CitedBy_id | crossref_primary_10_1097_MOL_0000000000000106 crossref_primary_10_1128_JVI_03584_14 crossref_primary_10_1517_17425255_2_3_429 crossref_primary_10_1071_SH06052 crossref_primary_10_1016_j_virol_2006_06_008 crossref_primary_10_1128_JVI_00252_06 crossref_primary_10_3389_fimmu_2022_903884 crossref_primary_10_7554_eLife_18296 crossref_primary_10_1128_mBio_01369_21 crossref_primary_10_1186_1742_4690_4_70 crossref_primary_10_1128_JVI_00288_07 crossref_primary_10_1186_1471_2334_13_250 crossref_primary_10_1186_1742_4690_9_85 crossref_primary_10_3389_fmicb_2014_00232 crossref_primary_10_1128_JVI_00337_11 crossref_primary_10_1371_journal_ppat_1002442 crossref_primary_10_1016_j_virol_2008_12_031 crossref_primary_10_2217_fvl_10_93 crossref_primary_10_1128_JVI_00259_09 crossref_primary_10_2217_fvl_09_53 crossref_primary_10_1016_j_vaccine_2016_06_034 crossref_primary_10_1097_QAD_0000000000002385 crossref_primary_10_1021_bi100466q crossref_primary_10_1039_C5FO01329A crossref_primary_10_1021_acsinfecdis_0c00500 crossref_primary_10_1126_scisignal_129re8 crossref_primary_10_1186_s12889_018_5852_4 crossref_primary_10_1189_jlb_0206113 crossref_primary_10_1038_s41598_019_49647_3 crossref_primary_10_1093_infdis_jir170 crossref_primary_10_1186_1743_422X_11_152 crossref_primary_10_3389_fimmu_2014_00687 crossref_primary_10_7554_eLife_41431 crossref_primary_10_3390_life14040449 crossref_primary_10_1128_JVI_00137_17 crossref_primary_10_1128_mBio_01396_14 crossref_primary_10_1186_1471_2172_14_4 crossref_primary_10_1038_s41564_019_0372_2 crossref_primary_10_1194_jlr_M023119 crossref_primary_10_1371_journal_ppat_1000719 crossref_primary_10_3390_v9060129 crossref_primary_10_1186_1742_4690_3_33 crossref_primary_10_1128_JVI_00330_09 crossref_primary_10_1128_mBio_02956_19 crossref_primary_10_3390_ph15020212 crossref_primary_10_3390_v14061313 crossref_primary_10_2217_17469600_2_1_37 crossref_primary_10_1128_JVI_01150_08 crossref_primary_10_1002_psc_2706 crossref_primary_10_1016_j_plipres_2013_09_002 crossref_primary_10_1097_QAD_0b013e32834507f0 crossref_primary_10_1124_mol_110_065029 crossref_primary_10_1097_QAD_0000000000003853 crossref_primary_10_1016_j_coviro_2016_06_014 crossref_primary_10_1186_1742_4690_2_73 crossref_primary_10_2217_17460794_1_4_509 crossref_primary_10_1016_j_celrep_2022_111674 crossref_primary_10_1161_ATVBAHA_113_302191 crossref_primary_10_1371_journal_pone_0025684 crossref_primary_10_1089_hgtb_2016_150 crossref_primary_10_1371_journal_pone_0022730 crossref_primary_10_1186_1743_422X_9_31 crossref_primary_10_1371_journal_pone_0147421 crossref_primary_10_2217_hiv_09_9 crossref_primary_10_1097_QAD_0000000000001648 crossref_primary_10_1186_1742_4690_9_55 crossref_primary_10_1189_jlb_0306157 crossref_primary_10_3390_ijms22041593 crossref_primary_10_1074_jbc_RA118_004630 crossref_primary_10_1186_s12977_014_0098_4 crossref_primary_10_7603_s40681_015_0007_8 crossref_primary_10_1096_fj_202301239RR crossref_primary_10_1002_sita_200600113 crossref_primary_10_1016_j_cca_2015_09_014 crossref_primary_10_1016_j_cytogfr_2015_09_001 |
| Cites_doi | 10.1084/jem.20040061 10.1016/S0021-9258(18)64849-5 10.1073/pnas.240459697 10.1128/JVI.72.10.7992-8001.1998 10.1128/JVI.76.20.10356-10364.2002 10.1073/pnas.241320298 10.1073/pnas.90.11.5181 10.1073/pnas.1437453100 10.1042/bj3080031 10.1128/JVI.75.17.7913-7924.2001 10.1016/0753-3322(94)90077-9 10.1172/JCI0215593 10.1074/jbc.M306380200 10.1128/MMBR.67.2.226-237.2003 10.1128/JVI.77.3.1916-1926.2003 10.1128/JVI.74.7.3264-3272.2000 10.1089/088922201300343690 10.1074/jbc.M401621200 10.1128/JVI.77.2.1392-1402.2003 10.1128/JVI.77.8.4805-4817.2003 10.1093/embo-reports/kvd025 10.1128/JVI.77.19.10548-10556.2003 10.1074/jbc.M207371200 |
| ContentType | Journal Article |
| Copyright | 2005 INIST-CNRS Copyright © 2005, American Society for Microbiology 2005 |
| Copyright_xml | – notice: 2005 INIST-CNRS – notice: Copyright © 2005, American Society for Microbiology 2005 |
| DBID | IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7T5 7U9 8FD FR3 H94 P64 RC3 7X8 5PM |
| DOI | 10.1128/JVI.79.15.10053-10058.2005 |
| DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Immunology Abstracts Virology and AIDS Abstracts Technology Research Database Engineering Research Database AIDS and Cancer Research Abstracts Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Genetics Abstracts Virology and AIDS Abstracts Technology Research Database AIDS and Cancer Research Abstracts Immunology Abstracts Engineering Research Database Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
| DatabaseTitleList | CrossRef Genetics Abstracts MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1098-5514 |
| EndPage | 10058 |
| ExternalDocumentID | 10_1128_JVI_79_15_10053_10058_2005 16014965 16956653 jvi_79_15_10053 |
| Genre | Research Support, U.S. Gov't, P.H.S Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIAID NIH HHS grantid: R21 AI52028 – fundername: NHGRI NIH HHS grantid: P50 HG002360 – fundername: NIAID NIH HHS grantid: R01 AI058894 |
| GroupedDBID | --- -~X .55 .GJ 08R 0R~ 18M 29L 2WC 39C 3O- 4.4 41~ 53G 5GY 5RE 5VS 6TJ 85S AAUGY AAYJJ ABPPZ ABPTK ACGFO ACNCT ADBBV AENEX AFDAS AFFNX AI. ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BTFSW C1A CS3 D0S DIK E3Z EBS EJD F20 F5P FRP GX1 H13 HYE HZ~ IH2 IQODW KQ8 MVM N9A O9- OHT OK1 P2P RHF RHI RNS RPM RSF TR2 UCJ UPT VH1 W2D W8F WH7 WOQ X7M XFK Y6R YQT ZA5 ZGI ZXP ~02 ~KM AGVNZ CGR CUY CVF ECM EIF NPM AAYXX CITATION 7T5 7U9 8FD FR3 H94 P64 RC3 7X8 5PM |
| ID | FETCH-LOGICAL-c513t-14fd5c2ad58767ed4f55a2a0ac4666d348d76c5e08db0a9f00dd41975f60167e3 |
| IEDL.DBID | RPM |
| ISSN | 0022-538X |
| IngestDate | Tue Sep 17 21:13:43 EDT 2024 Sun Sep 29 07:33:42 EDT 2024 Thu Aug 15 22:29:08 EDT 2024 Thu Sep 12 19:51:07 EDT 2024 Sat Sep 28 07:44:42 EDT 2024 Sun Oct 22 16:04:46 EDT 2023 Wed May 18 15:31:48 EDT 2016 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 15 |
| Keywords | Immunopathology Microbiology HIV-1 virus Retroviridae Lipids AIDS Immune deficiency Lentivirus Uptake Cholesterol Virology Infection Virus Gene Viral disease T-Lymphocyte Human immunodeficiency virus Infected cell |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c513t-14fd5c2ad58767ed4f55a2a0ac4666d348d76c5e08db0a9f00dd41975f60167e3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Corresponding author. Present address: Department of Clinical Viro-Immunology, Sanquin Research, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands. Phone: 31 (20) 512-3317. Fax: 31 (20) 512-3310. E-mail: vantwout@sanquin.nl. |
| OpenAccessLink | https://doi.org/10.1128/jvi.79.15.10053-10058.2005 |
| PMID | 16014965 |
| PQID | 17381204 |
| PQPubID | 23462 |
| PageCount | 6 |
| ParticipantIDs | proquest_miscellaneous_17381204 proquest_miscellaneous_68030967 highwire_asm_jvi_79_15_10053 pascalfrancis_primary_16956653 pubmed_primary_16014965 pubmedcentral_primary_oai_pubmedcentral_nih_gov_1181597 crossref_primary_10_1128_JVI_79_15_10053_10058_2005 |
| PublicationCentury | 2000 |
| PublicationDate | 2005-08-01 |
| PublicationDateYYYYMMDD | 2005-08-01 |
| PublicationDate_xml | – month: 08 year: 2005 text: 2005-08-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | Washington, DC |
| PublicationPlace_xml | – name: Washington, DC – name: United States |
| PublicationTitle | Journal of Virology |
| PublicationTitleAlternate | J Virol |
| PublicationYear | 2005 |
| Publisher | American Society for Microbiology |
| Publisher_xml | – name: American Society for Microbiology |
| References | 12239312 - J Virol. 2002 Oct;76(20):10356-64 12502855 - J Virol. 2003 Jan;77(2):1392-402 14570906 - J Biol Chem. 2004 Jan 2;279(1):704-12 11265761 - EMBO Rep. 2000 Aug;1(2):190-6 15314078 - J Exp Med. 2004 Aug 16;200(4):541-7 11994399 - J Clin Invest. 2002 May;109(9):1125-31 7522603 - Biomed Pharmacother. 1994;48(2):63-7 7755579 - Biochem J. 1995 May 15;308 ( Pt 1):31-8 13428781 - J Biol Chem. 1957 May;226(1):497-509 12794191 - Microbiol Mol Biol Rev. 2003 Jun;67(2):226-37, table of contents 11483736 - J Virol. 2001 Sep;75(17):7913-24 11095714 - Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13523-5 11717449 - Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13925-30 11485618 - AIDS Res Hum Retroviruses. 2001 Jul 20;17(11):1009-19 12663787 - J Virol. 2003 Apr;77(8):4805-17 10708443 - J Virol. 2000 Apr;74(7):3264-72 12431990 - J Biol Chem. 2003 Jan 31;278(5):3153-61 12525626 - J Virol. 2003 Feb;77(3):1916-26 9733838 - J Virol. 1998 Oct;72(10):7992-8001 12824470 - Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8460-5 8389472 - Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5181-5 15133044 - J Biol Chem. 2004 Jul 23;279(30):31398-408 12970439 - J Virol. 2003 Oct;77(19):10548-56 e_1_3_2_9_2 e_1_3_2_15_2 e_1_3_2_8_2 e_1_3_2_16_2 e_1_3_2_7_2 e_1_3_2_17_2 e_1_3_2_6_2 e_1_3_2_18_2 e_1_3_2_19_2 e_1_3_2_20_2 e_1_3_2_10_2 e_1_3_2_21_2 e_1_3_2_5_2 e_1_3_2_11_2 e_1_3_2_22_2 e_1_3_2_4_2 e_1_3_2_12_2 e_1_3_2_23_2 e_1_3_2_3_2 e_1_3_2_13_2 e_1_3_2_24_2 e_1_3_2_2_2 e_1_3_2_14_2 |
| References_xml | – ident: e_1_3_2_4_2 doi: 10.1084/jem.20040061 – ident: e_1_3_2_6_2 doi: 10.1016/S0021-9258(18)64849-5 – ident: e_1_3_2_20_2 doi: 10.1073/pnas.240459697 – ident: e_1_3_2_19_2 doi: 10.1128/JVI.72.10.7992-8001.1998 – ident: e_1_3_2_7_2 doi: 10.1128/JVI.76.20.10356-10364.2002 – ident: e_1_3_2_16_2 doi: 10.1073/pnas.241320298 – ident: e_1_3_2_2_2 doi: 10.1073/pnas.90.11.5181 – ident: e_1_3_2_24_2 doi: 10.1073/pnas.1437453100 – ident: e_1_3_2_8_2 doi: 10.1042/bj3080031 – ident: e_1_3_2_12_2 doi: 10.1128/JVI.75.17.7913-7924.2001 – ident: e_1_3_2_14_2 doi: 10.1016/0753-3322(94)90077-9 – ident: e_1_3_2_10_2 doi: 10.1172/JCI0215593 – ident: e_1_3_2_18_2 doi: 10.1074/jbc.M306380200 – ident: e_1_3_2_3_2 doi: 10.1128/MMBR.67.2.226-237.2003 – ident: e_1_3_2_5_2 doi: 10.1128/JVI.77.3.1916-1926.2003 – ident: e_1_3_2_15_2 doi: 10.1128/JVI.74.7.3264-3272.2000 – ident: e_1_3_2_11_2 doi: 10.1089/088922201300343690 – ident: e_1_3_2_22_2 doi: 10.1074/jbc.M401621200 – ident: e_1_3_2_23_2 doi: 10.1128/JVI.77.2.1392-1402.2003 – ident: e_1_3_2_9_2 doi: 10.1128/JVI.77.8.4805-4817.2003 – ident: e_1_3_2_13_2 doi: 10.1093/embo-reports/kvd025 – ident: e_1_3_2_21_2 doi: 10.1128/JVI.77.19.10548-10556.2003 – ident: e_1_3_2_17_2 doi: 10.1074/jbc.M207371200 |
| SSID | ssj0014464 |
| Score | 2.1755035 |
| Snippet | Article Usage Stats
Services
JVI
Citing Articles
Google Scholar
PubMed
Related Content
Social Bookmarking
CiteULike
Delicious
Digg
Facebook
Google+
Mendeley... Several recent reports indicate that cholesterol might play an important role in human immunodeficiency virus type 1 (HIV-1) replication. We investigated the... ABSTRACT Several recent reports indicate that cholesterol might play an important role in human immunodeficiency virus type 1 (HIV-1) replication. We... |
| SourceID | pubmedcentral proquest crossref pubmed pascalfrancis highwire |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 10053 |
| SubjectTerms | Aspartic Acid Endopeptidases - genetics Biological and medical sciences Cell Line Cholesterol - genetics Cholesterol - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Profiling HIV Infections - virology HIV-1 - genetics HIV-1 - metabolism Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Jurkat Cells Medical sciences Microbiology Miscellaneous Oligonucleotide Array Sequence Analysis T-Lymphocytes - metabolism T-Lymphocytes - virology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virology Virus-Cell Interactions |
| Title | Nef Induces Multiple Genes Involved in Cholesterol Synthesis and Uptake in Human Immunodeficiency Virus Type 1-Infected T Cells |
| URI | http://jvi.asm.org/content/79/15/10053.abstract https://www.ncbi.nlm.nih.gov/pubmed/16014965 https://search.proquest.com/docview/17381204 https://search.proquest.com/docview/68030967 https://pubmed.ncbi.nlm.nih.gov/PMC1181597 |
| Volume | 79 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1NbxMxELXaSkhcEN9sKcUHrpvY2fXHHlFE1VRKhURT5WY5tlcsJJuom1Tqib_OjHcXEgQXLjkkE0vZscfzMm_eEPKhUNxrGWQaCm9TLDmmVgLm0dopX2bMKYUNztNreTnLr-ZifkRE3wsTSftuUQ3q5WpQV18jt3KzcsOeJzb8PB1jsyQkwsNjcqyyrIfoXekA8E3eS4TDaZ53SqMQh4dXt5OBKgZcIDdAICeLCR3_V0HtUIloAS-Z_QuqFw1GzqRt4LGV7byLvyWkf_Iq9y6qi6fkSZdh0o_tL3lGjkL9nDxqZ04-vCA_rkNJcWAHBAg67eiEFNWnG3gbgtV98LSq6RgH56KKwnpJvzzUkCc2VUNt7elss7XfA9rECgCdYIvJ2gfUosBGTnpb3e0aigiX8nQS2V6w5g0dh-WyeUlmF59uxpdpN4UhdYJn25TnpRduZL2AwKmCz0sh7Mgy63KAPj7LtVfSicC0XzBblIx5n_NCiRKVXlTIXpGTel2HN4QqAWALQqRTDoCJlLZchOAkKzV3GQSDhGT9ozebVmzDRJAy0gZ8Z1RhuDDRd_FV4xBNkZCz3kvGNivz7b7at0zI-YHnfq8sARtKNHjfu9LA2cKCia3DetcYriCfGbH83xZSY4lKqoS8bl2_t3q7nRKiDjbFLwPU9T78BLZ71Pfutvfpf3_zLXkcFWYjT_GMnGzvduEd5E7bxXk8Kz8BomQV_A |
| link.rule.ids | 230,315,733,786,790,891,27957,27958,53827,53829 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Pb9MwFLbGEILL-M0KY_OBa9L8sp0cUcXUjrVCoq16s1zb0cLatFraSePCv857TgLtBAe49BA7lpo8P78v73vfI-RDJkKTcss9mxnlYcrRUxwwT5pqYfI40EJggfNwxPuT5GLGZgeEtbUwjrSv54VfLpZ-WVw5buV6qbstT6z7ZdjDYkkIhLsPyEPYr5FoQXqTPACEk7Qi4TA-a7RGwRN3L6YDX2R-yJAdwJCVFbDUfVlB9VCOeAGPmd0jqpUNRtakquDB5XXHiz-FpPeZlTtH1flTMm3_ZM1Qufa3m7mvv9_Tf_znp_CMHDXBK_1YDz8nB7Z8QR7V7SzvXpIfI5tT7AUCvocOG6YiRWHrCi6DH7y1hhYl7WFPXhRoWC3o17sSQtCqqKgqDZ2sN-ra4hyXXKADrF5ZGYsyF1gjSqfFzbaiCJ5p6A0ckQzWHNOeXSyqV2Ry_mnc63tNgwdPszDeeGGSG6YjZRj4ZGFNkjOmIhUonQCqMnGSGsE1s0Fq5oHK8iAwJgkzwXIUkRE2fk0Oy1VpjwkVDHAceF8tNGAezlU-t1bzIE9DHYOf6ZC4fadyXet4SId_olSCUUiRyZBJZxTuN8X-nKxDTtrXL1W1lN9ui92ZHXK6ZxK_V-YAOzlOOGttRMK2xVyMKu1qW8lQQKgUBcnfZ_AUs19cdMib2qZ2Vq_ttEPEnrX9moCS4fsjYENOOryxmbf_fecZedwfDy_l5WD0-R154oRsHR3yhBxubrb2PYRom_mp25A_ASkON_Q |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Pb9MwFLZgCMSF8ZvC2HzgmjRpYjs5orJqHbSaxDpVXCzXdkRYm1ZLOmlc-Nd5z0kgneCySw_Ji6Wmn5_fV3_-HiEfUhGahFvu2dQoD7ccPcWB8ySJFiaLAi0EHnCeTPnJLD6ds3mn1ZcT7etF7hfLlV_k3522crPS_VYn1j-bDPGwJBTC_Y3J-vfJA5izg7Ql6s0GArCcuDUKh_vzxm8UsnH_9GLsi9QPGSoEGCqzApa4f1fQQZQjZ8ClprtMtdbBqJxUJby8rO568a-y9La6srNcjfbJt_aL1iqVS39bLXz985YH5J3exFPypCli6cc65Bm5Z4vn5GHd1vLmBfk1tRnFniCQg-ikUSxSNLgu4TLkw2traF7QIfbmRaOG9ZJ-vSmgFC3zkqrC0NmmUpcWY9wmAx3jKZa1sWh3gWdF6UV-tS0pkmgaemMnKIMxz-nQLpflSzIbHZ8PT7ym0YOnWRhVXhhnhumBMgxys7AmzhhTAxUoHQO7MlGcGME1s0FiFoFKsyAwJg5TwTI0kxE2ekX2inVh3xAqGPA5yMJaaOA-nKtsYa3mQZaEOoJ80yNR-7vKTe3nIR0PGiQSgCFFKkMmHTDcZ4J9OlmPHLQQkKpcyR_XeTeyRw53YPF3ZA70k2PAUYsTCdMX92RUYdfbUoYCSqZBEP8_gie4C8ZFj7yucdUZvcZqj4gdxP0JQOvw3TuAI2ch3uDm7Z2fPCKPzj6N5Jfx9PM78tj52TpV5AHZq6629j1UatXi0M3J3-5iOnQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Nef+Induces+Multiple+Genes+Involved+in+Cholesterol+Synthesis+and+Uptake+in+Human+Immunodeficiency+Virus+Type+1-Infected+T+Cells&rft.jtitle=Journal+of+virology&rft.au=van+%E2%80%B2t+Wout%2C+Ang%C3%A9lique+B.&rft.au=Swain%2C+J.+Victor&rft.au=Schindler%2C+Michael&rft.au=Rao%2C+Ushnal&rft.date=2005-08-01&rft.pub=American+Society+for+Microbiology&rft.issn=0022-538X&rft.eissn=1098-5514&rft.volume=79&rft.issue=15&rft.spage=10053&rft.epage=10058&rft_id=info:doi/10.1128%2FJVI.79.15.10053-10058.2005&rft_id=info%3Apmid%2F16014965&rft.externalDBID=PMC1181597 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-538X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-538X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-538X&client=summon |