Cellular PSMB4 Protein Suppresses Influenza A Virus Replication through Targeting NS1 Protein

• Published in: Viruses Vol. 14; no. 10; p. 2277
• Main Authors: Yang, Chee-Hing, Hsu, Che-Fang, Lai, Xiang-Qing, Chan, Yu-Ru, Li, Hui-Chun, Lo, Shih-Yen
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.10.2022; MDPI
• Subjects: Antiviral drugs; Cellular proteins; Cloning; Confocal microscopy; Development and progression; Experiments; Gene expression; Immune response; Immunoprecipitation; Infections; Influenza; Influenza A; influenza A virus; Interferon; Kinases; Mammalian cells; MG132; Monoclonal antibodies; NS1 protein; Physiological aspects; Plasmids; Proteasomes; protein degradation; Proteins; PSMB4; Replication; Viral infections; Viral proteins; Virus research; Taiwan; United States > US; Germany

The nonstructural protein 1 (NS1) of influenza A virus (IAV) possesses multiple functions, such as the inhibition of the host antiviral immune responses, to facilitate viral infection. To search for cellular proteins interacting with the IAV NS1 protein, the yeast two-hybrid system was adopted. Prot...