Role of Src family tyrosine kinases in the down‐regulation of epidermal growth factor signaling in PC12 cells

• Published in: Genes to cells : devoted to molecular & cellular mechanisms Vol. 10; no. 12; pp. 1175 - 1187
• Main Authors: Kasai, Atsuko, Shima, Takaki, Okada, Masato
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Science Ltd 01.12.2005
• Subjects: Animals; Cell Differentiation; Cell Proliferation; Down-Regulation; Endocytosis; Epidermal Growth Factor - metabolism; Epidermal Growth Factor - pharmacology; Fibroblasts - metabolism; Membrane Microdomains - drug effects; Membrane Microdomains - metabolism; Mitogen-Activated Protein Kinase 3 - metabolism; Neurites - enzymology; Neurites - metabolism; PC12 Cells; Protein Binding; Rats; Receptor, Epidermal Growth Factor - metabolism; Signal Transduction; src-Family Kinases - physiology; Time Factors

Src family tyrosine kinases (SFKs) play pivotal roles as molecular switches for various intracellular signaling pathways. SFKs have been implicated in epidermal growth factor (EGF) signaling, although their precise mechanisms of action in this pathway remain elusive. To address this issue, we focuse...