Sphingolipid metabolic flow controls phosphoinositide turnover at the trans‐Golgi network

• Published in: The EMBO journal Vol. 36; no. 12; pp. 1736 - 1754
• Main Authors: Capasso, Serena, Sticco, Lucia, Rizzo, Riccardo, Pirozzi, Marinella, Russo, Domenico, Dathan, Nina A, Campelo, Felix, van Galen, Josse, Hölttä‐Vuori, Maarit, Turacchio, Gabriele, Hausser, Angelika, Malhotra, Vivek, Riezman, Isabelle, Riezman, Howard, Ikonen, Elina, Luberto, Chiara, Parashuraman, Seetharaman, Luini, Alberto, D'Angelo, Giovanni
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.06.2017; Springer Nature B.V; John Wiley and Sons Inc
• Subjects: Ceramide; Cholesterol; Circuits; Compartments; Consumption; Control systems; Counterbalances; Dephosphorylation; Effectors; EMBO20; EMBO21; Enrichment; Feedback; Flow control; Fluxes; Glycosphingolipids; HeLa Cells; Homeostasis; Humans; Interrupts; Lipid composition; lipid territories; Lipids; lipid‐transfer protein; Localization; Maintenance; Mathematical models; membrane contact sites; Membrane trafficking; Membranes; Metabolism; Models, Biological; Negative feedback; Phosphatidylinositols - metabolism; PtdInsP; Signal transduction; Signaling; Sphingolipids; Sphingolipids - metabolism; Sphingomyelin; trans-Golgi Network - metabolism; Transport; ceramide; PtdIns; lipid territories; membrane contact sites; lipid‐transfer protein; PtdInsP

Sphingolipids are membrane lipids globally required for eukaryotic life. The sphingolipid content varies among endomembranes with pre‐ and post‐Golgi compartments being poor and rich in sphingolipids, respectively. Due to this different sphingolipid content, pre‐ and post‐Golgi membranes serve diffe...