Improved Insulin Sensitivity After Exercise: Focus on Insulin Signaling

• Published in: Obesity (Silver Spring, Md.) Vol. 17; no. n3s; pp. S15 - S20
• Main Authors: Frosig, Christian, Richter, Erik A
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2009
• Subjects: Biological Transport; Blood Glucose - metabolism; Diabetes; Exercise; Exercise - physiology; Glucose; Glucose Transporter Type 4 - metabolism; glucose transporters; Homeostasis; Humans; insulin; Insulin - metabolism; Insulin resistance; Insulin Resistance - physiology; Kinases; Muscle, Skeletal - metabolism; muscles; Musculoskeletal system; noninsulin-dependent diabetes mellitus; obesity; Phosphorylation; Physical fitness; Physiology; protein kinase C; Proteins; signal transduction; Signal Transduction - physiology

After a single bout of exercise, the ability of insulin to stimulate glucose uptake is markedly improved locally in the previously active muscles. This makes exercise a potent stimulus counteracting insulin resistance characterizing type 2 diabetes (T2D). It is believed that at least part of the mec...