The SUMO protease SENP3 regulates mitochondrial autophagy mediated by Fis1

• Published in: EMBO reports Vol. 23; no. 2; pp. e48754 - n/a
• Main Authors: Waters, Emily, Wilkinson, Kevin A, Harding, Amy L, Carmichael, Ruth E, Robinson, Darren, Colley, Helen E, Guo, Chun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.02.2022; Springer Nature B.V; John Wiley and Sons Inc
• Subjects: Amino acids; Autophagy; Cysteine Endopeptidases - genetics; Cysteine Endopeptidases - metabolism; Depletion; EMBO07; EMBO31; Fis1; Localization; Mitochondria; Mitochondria - metabolism; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; Mitophagy; Mutation; organellar stress; Peptide Hydrolases - metabolism; Protease; Proteinase; Quality control; SENP3; SUMO; SUMO protein; Ubiquitin; Ubiquitin-protein ligase; Fis1; mitophagy; SUMO; SENP3; organellar stress
• ISSN: 1469-221X; 1469-3178; 1469-3178
• DOI: 10.15252/embr.201948754

Mitochondria are unavoidably subject to organellar stress resulting from exposure to a range of reactive molecular species. Consequently, cells operate a poorly understood quality control programme of mitophagy to facilitate elimination of dysfunctional mitochondria. Here, we used a model stressor,...