Matrilysin‐1 (MMP7) cleaves galectin‐3 and inhibits wound healing in intestinal epithelial cells

• Published in: Inflammatory bowel diseases Vol. 17; no. 1; pp. 260 - 267
• Main Authors: Puthenedam, Manjula, Wu, Feng, Shetye, Alysha, Michaels, Alex, Rhee, Ki‐Jong, Kwon, John H.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.01.2011
• Subjects: Cell migration; Cell Movement; Cells, Cultured; Epithelial cells; Epithelial Cells - metabolism; Extracellular matrix; Galectin 3 - metabolism; galectin-3; Humans; inflammatory bowel disease; Inflammatory bowel diseases; Intestine; Intestines - metabolism; Lectins; Mass spectroscopy; Matrilysin; Matrix Metalloproteinase 7 - metabolism; MMP7; Proteinase; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Ulcers; Western blotting; Wound Healing

Background: Galectin‐3 is an animal lectin that has been implicated in wound healing and is decreased in inflammatory bowel disease (IBD). Matrix metalloproteinase‐7 (MMP7), also known as matrilysin‐1, a protease shown to cleave extracellular matrix proteins, is highly expressed in IBD tissues, espe...