Dopaminergic synapses in the caudate of subjects with schizophrenia: Relationship to treatment response

• Published in: Synapse (New York, N.Y.) Vol. 63; no. 6; pp. 520 - 530
• Main Authors: Roberts, Rosalinda C., Roche, Joy K., Conley, Robert R., Lahti, Adrienne C.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.06.2009
• Subjects: Antipsychotic Agents - pharmacology; basal ganglia; Caudate Nucleus - drug effects; Caudate Nucleus - metabolism; Caudate Nucleus - physiopathology; Dopamine - metabolism; Drug Resistance - physiology; Humans; Immunohistochemistry; Microscopy, Electron, Transmission; postmortem; psychosis; Receptors, Dopamine - metabolism; Schizophrenia - drug therapy; Schizophrenia - metabolism; Schizophrenia - physiopathology; symptoms; Synapses - drug effects; Synapses - metabolism; Synapses - ultrastructure; Synaptic Transmission - physiology; treatment; Tyrosine 3-Monooxygenase - analysis; Tyrosine 3-Monooxygenase - metabolism; ultrastructure

The typical symptoms of schizophrenia (SZ) are psychotic symptoms (hallucinations, delusions, disorders of thought or speech, grossly disorganized behavior) as well as cognitive impairments and negative symptoms. Not all patients respond to treatment and in those who do, only psychotic symptoms are...