Emerging Roles for MicroRNAs in Diabetic Microvascular Disease: Novel Targets for Therapy

Abstract Chronic, low-grade systemic inflammation and impaired microvascular function are critical hallmarks in the development of insulin resistance. Accordingly, insulin resistance is a major risk factor for type 2 diabetes and cardiovascular disease. Accumulating studies demonstrate that restorat...

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Bibliographic Details
Published inEndocrine reviews Vol. 38; no. 2; pp. 145 - 168
Main Authors Zhang, Yu, Sun, Xinghui, Icli, Basak, Feinberg, Mark W.
Format Journal Article
LanguageEnglish
Published Washington, DC Endocrine Society 01.04.2017
Copyright Oxford University Press
Oxford University Press
Subjects
Cardiovascular disease
Cardiovascular diseases
Complications
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - therapy
Diabetic Angiopathies - metabolism
Diabetic Angiopathies - therapy
Diabetic Cardiomyopathies - metabolism
Diabetic Cardiomyopathies - therapy
Diabetic Nephropathies - metabolism
Diabetic Nephropathies - therapy
Disease resistance
Editor's Choice
Gene expression
Health risks
Homeostasis
Humans
Injury prevention
Insulin
Insulin resistance
MicroRNAs
MicroRNAs - metabolism
MicroRNAs - therapeutic use
Microvasculature
miRNA
Nephropathy
Resistance factors
Restoration
Retinopathy
Reviews
Ribonucleic acid
Risk analysis
Risk factors
RNA
Wound healing
Online AccessGet full text

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Abstract Abstract Chronic, low-grade systemic inflammation and impaired microvascular function are critical hallmarks in the development of insulin resistance. Accordingly, insulin resistance is a major risk factor for type 2 diabetes and cardiovascular disease. Accumulating studies demonstrate that restoration of impaired function of the diabetic macro- and microvasculature may ameliorate a range of cardiovascular disease states and diabetes-associated complications. In this review, we focus on the emerging role of microRNAs (miRNAs), noncoding RNAs that fine-tune target gene expression and signaling pathways, in insulin-responsive tissues and cell types important for maintaining optimal vascular homeostasis and preventing the sequelae of diabetes-induced end organ injury. We highlight current pathophysiological paradigms of miRNAs and their targets involved in regulating the diabetic microvasculature in a range of diabetes-associated complications such as retinopathy, nephropathy, wound healing, and myocardial injury. We provide an update of the potential use of circulating miRNAs diagnostically in type I or type II diabetes. Finally, we discuss emerging delivery platforms for manipulating miRNA expression or function as the next frontier in therapeutic intervention to improve diabetes-associated microvascular dysfunction and its attendant clinical consequences.
AbstractList Chronic, low-grade systemic inflammation and impaired microvascular function are critical hallmarks in the development of insulin resistance. Accordingly, insulin resistance is a major risk factor for type 2 diabetes and cardiovascular disease. Accumulating studies demonstrate that restoration of impaired function of the diabetic macro- and microvasculature may ameliorate a range of cardiovascular disease states and diabetes-associated complications. In this review, we focus on the emerging role of microRNAs (miRNAs), noncoding RNAs that fine-tune target gene expression and signaling pathways, in insulin-responsive tissues and cell types important for maintaining optimal vascular homeostasis and preventing the sequelae of diabetes-induced end organ injury. We highlight current pathophysiological paradigms of miRNAs and their targets involved in regulating the diabetic microvasculature in a range of diabetes-associated complications such as retinopathy, nephropathy, wound healing, and myocardial injury. We provide an update of the potential use of circulating miRNAs diagnostically in type I or type II diabetes. Finally, we discuss emerging delivery platforms for manipulating miRNA expression or function as the next frontier in therapeutic intervention to improve diabetes-associated microvascular dysfunction and its attendant clinical consequences.Chronic, low-grade systemic inflammation and impaired microvascular function are critical hallmarks in the development of insulin resistance. Accordingly, insulin resistance is a major risk factor for type 2 diabetes and cardiovascular disease. Accumulating studies demonstrate that restoration of impaired function of the diabetic macro- and microvasculature may ameliorate a range of cardiovascular disease states and diabetes-associated complications. In this review, we focus on the emerging role of microRNAs (miRNAs), noncoding RNAs that fine-tune target gene expression and signaling pathways, in insulin-responsive tissues and cell types important for maintaining optimal vascular homeostasis and preventing the sequelae of diabetes-induced end organ injury. We highlight current pathophysiological paradigms of miRNAs and their targets involved in regulating the diabetic microvasculature in a range of diabetes-associated complications such as retinopathy, nephropathy, wound healing, and myocardial injury. We provide an update of the potential use of circulating miRNAs diagnostically in type I or type II diabetes. Finally, we discuss emerging delivery platforms for manipulating miRNA expression or function as the next frontier in therapeutic intervention to improve diabetes-associated microvascular dysfunction and its attendant clinical consequences.
Chronic, low-grade systemic inflammation and impaired microvascular function are critical hallmarks in the development of insulin resistance. Accordingly, insulin resistance is a major risk factor for type 2 diabetes and cardiovascular disease. Accumulating studies demonstrate that restoration of impaired function of the diabetic macro- and microvasculature may ameliorate a range of cardiovascular disease states and diabetes-associated complications. In this review, we focus on the emerging role of microRNAs (miRNAs), noncoding RNAs that fine-tune target gene expression and signaling pathways, in insulin-responsive tissues and cell types important for maintaining optimal vascular homeostasis and preventing the sequelae of diabetes-induced end organ injury. We highlight current pathophysiological paradigms of miRNAs and their targets involved in regulating the diabetic microvasculature in a range of diabetes-associated complications such as retinopathy, nephropathy, wound healing, and myocardial injury. We provide an update of the potential use of circulating miRNAs diagnostically in type I or type II diabetes. Finally, we discuss emerging delivery platforms for manipulating miRNA expression or function as the next frontier in therapeutic intervention to improve diabetes-associated microvascular dysfunction and its attendant clinical consequences.
Abstract Chronic, low-grade systemic inflammation and impaired microvascular function are critical hallmarks in the development of insulin resistance. Accordingly, insulin resistance is a major risk factor for type 2 diabetes and cardiovascular disease. Accumulating studies demonstrate that restoration of impaired function of the diabetic macro- and microvasculature may ameliorate a range of cardiovascular disease states and diabetes-associated complications. In this review, we focus on the emerging role of microRNAs (miRNAs), noncoding RNAs that fine-tune target gene expression and signaling pathways, in insulin-responsive tissues and cell types important for maintaining optimal vascular homeostasis and preventing the sequelae of diabetes-induced end organ injury. We highlight current pathophysiological paradigms of miRNAs and their targets involved in regulating the diabetic microvasculature in a range of diabetes-associated complications such as retinopathy, nephropathy, wound healing, and myocardial injury. We provide an update of the potential use of circulating miRNAs diagnostically in type I or type II diabetes. Finally, we discuss emerging delivery platforms for manipulating miRNA expression or function as the next frontier in therapeutic intervention to improve diabetes-associated microvascular dysfunction and its attendant clinical consequences.
Impaired microvascular function is a hallmark during the development of insulin resistance and in diabetic subjects MicroRNAs, small noncoding RNAs that fine-tune gene expression, have emerged as critical regulators in insulin-responsive tissues and cell types important for maintaining vascular homeostasis and preventing the sequelae of diabetes-induced end organ injury Current pathophysiological paradigms of microRNAs and their target genes demonstrate novel mechanisms and therapeutic targets in regulating the diabetic microvasculature in diabetes-associated complications such as retinopathy, nephropathy, wound healing, and myocardial injury Circulating microRNAs in exosomes or microvesicles may be diagnostically useful in type I or type II diabetes Emerging delivery platforms for manipulating microRNA expression or function may serve as the next frontier in therapeutic intervention to improve diabetes-associated microvascular dysfunction and its attendant clinical consequences Chronic, low-grade systemic inflammation and impaired microvascular function are critical hallmarks in the development of insulin resistance. Accordingly, insulin resistance is a major risk factor for type 2 diabetes and cardiovascular disease. Accumulating studies demonstrate that restoration of impaired function of the diabetic macro- and microvasculature may ameliorate a range of cardiovascular disease states and diabetes-associated complications. In this review, we focus on the emerging role of microRNAs (miRNAs), noncoding RNAs that fine-tune target gene expression and signaling pathways, in insulin-responsive tissues and cell types important for maintaining optimal vascular homeostasis and preventing the sequelae of diabetes-induced end organ injury. We highlight current pathophysiological paradigms of miRNAs and their targets involved in regulating the diabetic microvasculature in a range of diabetes-associated complications such as retinopathy, nephropathy, wound healing, and myocardial injury. We provide an update of the potential use of circulating miRNAs diagnostically in type I or type II diabetes. Finally, we discuss emerging delivery platforms for manipulating miRNA expression or function as the next frontier in therapeutic intervention to improve diabetes-associated microvascular dysfunction and its attendant clinical consequences.
Author Feinberg, Mark W.
Zhang, Yu
Icli, Basak
Sun, Xinghui
AuthorAffiliation 1Department of Medicine, Cardiovascular Division, Brigham and Womenʼs Hospital, Harvard Medical School, Boston, MA 02115 2Department of Pharmacology & Pharmacy, the University of Hong Kong, Pokfulam, Hong Kong SAR, China
AuthorAffiliation_xml – name: 1Department of Medicine, Cardiovascular Division, Brigham and Womenʼs Hospital, Harvard Medical School, Boston, MA 02115 2Department of Pharmacology & Pharmacy, the University of Hong Kong, Pokfulam, Hong Kong SAR, China
Author_xml – sequence: 1
  givenname: Yu
  surname: Zhang
  fullname: Zhang, Yu
  organization: Department of Medicine, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115
– sequence: 2
  givenname: Xinghui
  surname: Sun
  fullname: Sun, Xinghui
  organization: Department of Medicine, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115
– sequence: 3
  givenname: Basak
  surname: Icli
  fullname: Icli, Basak
  organization: Department of Medicine, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115
– sequence: 4
  givenname: Mark W.
  surname: Feinberg
  fullname: Feinberg, Mark W.
  email: mfeinberg@partners.org
  organization: Department of Medicine, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28323921$$D View this record in MEDLINE/PubMed
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  article-title: Deep sequencing of small RNA repertoires in mice reveals metabolic disorders-associated hepatic miRNAs
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0080774
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Snippet Abstract Chronic, low-grade systemic inflammation and impaired microvascular function are critical hallmarks in the development of insulin resistance....
Chronic, low-grade systemic inflammation and impaired microvascular function are critical hallmarks in the development of insulin resistance. Accordingly,...
Impaired microvascular function is a hallmark during the development of insulin resistance and in diabetic subjects MicroRNAs, small noncoding RNAs that...
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SubjectTerms Cardiovascular disease
Cardiovascular diseases
Complications
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - therapy
Diabetic Angiopathies - metabolism
Diabetic Angiopathies - therapy
Diabetic Cardiomyopathies - metabolism
Diabetic Cardiomyopathies - therapy
Diabetic Nephropathies - metabolism
Diabetic Nephropathies - therapy
Disease resistance
Editor's Choice
Gene expression
Health risks
Homeostasis
Humans
Injury prevention
Insulin
Insulin resistance
MicroRNAs
MicroRNAs - metabolism
MicroRNAs - therapeutic use
Microvasculature
miRNA
Nephropathy
Resistance factors
Restoration
Retinopathy
Reviews
Ribonucleic acid
Risk analysis
Risk factors
RNA
Wound healing
Title Emerging Roles for MicroRNAs in Diabetic Microvascular Disease: Novel Targets for Therapy
URI https://www.ncbi.nlm.nih.gov/pubmed/28323921
https://www.proquest.com/docview/2187621023
https://www.proquest.com/docview/3129872070
https://www.proquest.com/docview/1880085033
https://pubmed.ncbi.nlm.nih.gov/PMC5460677
Volume 38
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