Folding and binding cascades: Dynamic landscapes and population shifts

• Published in: Protein Science Vol. 9; no. 1; pp. 10 - 19
• Main Authors: KUMAR, SANDEEP, MA, BUYONG, TSAI, CHUNG-JUNG, SINHA, NEETI, NUSSINOV, RUTH
• Format: Book Review Journal Article
• Language: English
• Published: Bristol Cambridge University Press 01.01.2000; Cold Spring Harbor Laboratory Press
• Subjects: allostery; binding; biological pathways; conformational ensembles; dynamic landscapes; folding; funnels; induced conformational change; Models, Molecular; Protein Binding; Protein Conformation; Protein Folding; REVIEWS; conformational ensembles; folding; binding; funnels; biological pathways; dynamic landscapes; induced conformational change; allostery

Whereas previously we have successfully utilized the folding funnels concept to rationalize binding mechanisms (Ma B, Kumar S, Tsai CJ, Nussinov R, 1999, Protein Eng 12:713–720) and to describe binding (Tsai CJ, Kumar S, Ma B, Nussinov R, 1999, Protein Sci 8:1181–1190), here we further extend the co...