The tumour suppressor OPCML promotes AXL inactivation by the phosphatase PTPRG in ovarian cancer

• Published in: EMBO reports Vol. 19; no. 8
• Main Authors: Antony, Jane, Zanini, Elisa, Kelly, Zoe, Tan, Tuan Zea, Karali, Evdoxia, Alomary, Mohammad, Jung, Youngrock, Nixon, Katherine, Cunnea, Paula, Fotopoulou, Christina, Paterson, Andrew, Roy‐Nawathe, Sushmita, Mills, Gordon B, Huang, Ruby Yun‐Ju, Thiery, Jean Paul, Gabra, Hani, Recchi, Chiara
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.08.2018; Springer Nature B.V; John Wiley and Sons Inc
• Subjects: Animals; AXL; Axl protein; Benzocycloheptenes - pharmacology; Cancer; Cell Adhesion Molecules - metabolism; Cell Line, Tumor; Cell migration; Cell Movement - drug effects; Cell Survival - drug effects; Chickens; Cholesterol; Cholesterol - metabolism; Coordination compounds; Deactivation; EMBO03; EMBO37; Enzyme Activation - drug effects; Epidermal growth factor receptors; Epithelial Cells - drug effects; Epithelial Cells - metabolism; Epithelial Cells - pathology; Fallopian Tubes - pathology; Female; Gene Silencing - drug effects; GPI-Linked Proteins - metabolism; Humans; Inactivation; Intercellular Signaling Peptides and Proteins - metabolism; Ligands; Lipids; MAP Kinase Signaling System - drug effects; Medical prognosis; Membrane Microdomains - metabolism; Motility; Neoplasm Invasiveness; OPCML; Ovarian cancer; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - pathology; Phosphatase; Phosphorylation - drug effects; Protein Binding - drug effects; Proto-Oncogene Proteins - metabolism; PTPRG; Receptor Protein-Tyrosine Kinases - metabolism; Receptor-Like Protein Tyrosine Phosphatases, Class 5 - metabolism; Signaling; Suppressors; Treatment Outcome; Triazoles - pharmacology; Tumor Suppressor Proteins - metabolism; Tumors; AXL; ovarian cancer; OPCML; PTPRG

In ovarian cancer, the prometastatic RTK AXL promotes motility, invasion and poor prognosis. Here, we show that reduced survival caused by AXL overexpression can be mitigated by the expression of the GPI‐anchored tumour suppressor OPCML. Further, we demonstrate that AXL directly interacts with OPCML...